Articles

Regarding Japanese primary aldosteronism, the low, intermediate, and high renin change groups (classified based on the response of renin to mineralocorticoid antagonist treatment) had CVD incidence of 2.1%, 0.5%, and 3.7%, respectively, during the 5-year study period.

Continuous positive airway pressure treatment significantly lowered 24-h systolic and diastolic blood pressure in patients with hypertension and obstructive sleep apnea.

27 million Japanese are hypertensive disease and 89.6% of them are treated with any anti-hypertensive medications. This is the first study utilizing the National Database of Health Insurance Claims and Specific Health Checkups to determine the number and age-adjusted prevalence of hypertensive patients and treated hypertensive patients in Japan.

Orthostatic and nocturnal changes in systolic blood pressure are inversely associated in older adults, probably due to aging-related autonomic nervous system deficits.

(A) The prevalence of PA was 6.1% of the total population. Among 55 patients with conclusive subtype differentiation of PA, 27% had APA, 65% had BAH, and 7% had UAH. (B) Patients with PA had a higher blood pressure and higher prevalence of target-organ damage than patients without PA. APA, aldosterone-producing adenoma; BAH, bilateral adrenal hyperplasia; ECG, electrocardiogram; LVH, left ventricular hypertrophy; PA, primary aldosteronism; SBP, systolic blood pressure; UAH, unilateral adrenal hyperplasia.

Twenty-four-hour urinary cortisol excretion is best associated with a decrease in the lumbar spine bone density via increased adrenal cortisol overproduction. DST overnight dexamethasone suppression test.

The impact of intrauterine hypoxia on acetylcholine (ACh)-mediated endothelium dependent vasodilatation in fetal sheep middle cerebral artery (MCA). Intrauterine hypoxia decreased CHRM3 expression, and inhibited NOS3 bioactivities due to ROS over-production and ERK1/2 inhibition, leading to MCA dysfunction.