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Predicting cognitive function and dementia risk in patients with hypertension

Hypertension Research (2024)Cite this article

Abstract

In spite of the fact that hypertension stand out as the main vascular risk factor for developing dementia, it is essential to acknowledge the presence of other risk factors, both vascular and non-vascular that contribute to increase this risk. This study stratified the dementia risk using CAIDE (Cardiovascular Risk Factors, Aging, and Incidence of Dementia) dementia risk score in a sample of 1279 hypertensive patients from the Heart-Brain Study in Argentina and to observed the association between the risk factors include in the CAIDE score and the current cognitive status. The average age of the sample was 60.2 ± 13.5 years (71% female) and the average years of education was 9.9 ± 5.1 years. To assess the current cognitive status, we used the Mini-mental test (MMSE), the clock drawing test (CDT) and Mini-Boston test. According to CAIDE score ( ≥9 points) the risk of dementia was 40.4% in the total sample and 28.1% in the middle-life hypertensive patients (between 47 to 53 years). An inverse association was observed between CAIDE score and the results of current cognitive tests (MMSE = R2 0.9128, p < 0.0001; CDT = R2 0.9215, p < 0.0001 y Mini-Boston= R2 0.829, p < 0.0001). The CAIDE score can predict the risk of dementia in hypertensive patients and its result was associated with the current cognitive status (result of cognitive tests).

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Heart and Brain Federal Network’s Researchers in Argentina

Alejandro E. De Cerchio3, Diego Cesario4, Paola Spósito5, Patricia Conti6, Ricardo Plunket7, José R. Romano8, Facundo Risso Patrón9

Funding

Funding

The investigation had not source of funding.

Author information

Authors and Affiliations

  1. Heart and Brain Unit. ICBA-Cardiovascular Institute, Buenos Aires, Argentina

    Gustavo H. Cerezo & Augusto Vicario

  2. Health Public School. Córdoba National University, Córdoba, Argentina

    Ruth A. Fernández & Julio E. Enders

  3. Arterial Hypertension Center. Cardiology Institute of Corrientes, Corrientes, Argentina

    Alejandro E. De Cerchio

  4. Hospital S.A.M.Co. (Community Health Care System), Villa Constitución, Santa Fe, Argentina

    Diego Cesario

  5. Arterial Hypertension Clinic. Hospital Maciel, Montevideo, Uruguay

    Paola Spósito

  6. Arterial Hypertension Section. Department of Internal Medicine. Hospital Italiano, Buenos Aires, Argentina

    Patricia Conti

  7. Servicio de Endocrinología. Hospital Privado Doctor Raúl Matera, Bahía Blanca, Provincia de Buenos Aires, Argentina

    Ricardo Plunket

  8. Cardiology Department. Clínica Vrsalovic, Formosa, Argentina

    José R. Romano

  9. Cedyt Medical Center, Tucumán, Argentina

    Facundo Risso Patrón

Authors
  1. Gustavo H. Cerezo
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  2. Ruth A. Fernández
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  3. Julio E. Enders
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  4. Augusto Vicario
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Consortia

Heart and Brain Federal Network’s Researchers in Argentina

  • Alejandro E. De Cerchio
  • , Diego Cesario
  • , Paola Spósito
  • , Patricia Conti
  • , Ricardo Plunket
  • , José R. Romano
  •  & Facundo Risso Patrón

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Correspondence to Augusto Vicario.

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Cerezo, G.H., Fernández, R.A., Enders, J.E. et al. Predicting cognitive function and dementia risk in patients with hypertension. Hypertens Res (2024). https://doi.org/10.1038/s41440-024-01650-6

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