Cell signalling is part of a complex system of communication that governs basic cellular activities and coordinates the actions of cells. Although cell signalling research has traditionally focused on the study of linear signalling cascades, it has become increasingly clear that there is considerable crosstalk between individual signalling pathways. This is not surprising, given that cells must simultaneously integrate multiple signals to regulate a complex set of cellular processes. To this end, there has been an important shift towards the study of signalling networks, which enables researchers to determine the effects of a single cellular change on a multitude of key signalling pathways. Increasing our knowledge of how signals are integrated into cellular networks is crucial to our understanding of normal cell behaviour and disease mechanisms. Furthermore, given that targeting a specific protein with any drug will have implications for the signalling network as a whole, understanding signal integration will provide valuable information towards the design of more effective therapeutics.

Nature Reviews Molecular Cell Biology and Nature Structural & Molecular Biology have teamed up to present an in-depth joint Focus on Signal Integration, with specially commissioned Reviews in each journal. These articles consider some of the key approaches used to study signalling networks, and discuss how various signals are integrated in different cellular contexts. The NPG library contains other relevant articles, including Reviews, on the broad topic of signal integration.


Integrating the signs


Nature Structural & Molecular Biology 17, 641 (2010)


Unraveling the paradoxes of plant hormone signaling integration

Yvon Jaillais & Joanne Chory


Nature Structural & Molecular Biology 17, 642-645 (2010)


Enhanced interrogation: emerging strategies for cell signaling inhibition

Rong Huang, Isabel Martinez-Ferrando & Philip A Cole


Nature Structural & Molecular Biology 17, 646-649 (2010)

The quest to understand heterotrimeric G protein signaling

John J G Tesmer


Nature Structural & Molecular Biology 17, 650-652 (2010)


Cell signalling: Making new connections


Nature Reviews Molecular Cell Biology 11, 386

Cell signalling: Of Rags and Ragulator


Nature Reviews Molecular Cell Biology 11, 388

Cell signalling: Regulation and crosstalk


Nature Reviews Molecular Cell Biology 11, 390


Multivariate signal integration

Rune Linding


Nature Reviews Molecular Cell Biology 11, 391


Signal integration through blending, bolstering and bifurcating of intracellular information

Catherine T Pawson and John D Scott


Nature Structural & Molecular Biology

Designing customized cell signalling circuits

Wendell A. Lim


Nature Reviews Molecular Cell Biology

When pathways collide: collaboration and connivance among signalling proteins in development

Helen McNeill and James R. Woodgett


Nature Reviews Molecular Cell Biology

Molecular mechanisms in signal transduction at the membrane

Jay T. Groves and John Kuriyan


Nature Structural & Molecular Biology

Signalling ballet in space and time

Boris N. Kholodenko, John F. Hancock and Walter Kolch


Nature Reviews Molecular Cell Biology

Decoding signalling networks by mass spectrometry-based proteomics

Chunaram Choudhary and Matthias Mann


Nature Reviews Molecular Cell Biology

Post-translational modifications in signal integration

Yonathan Lissanu Deribe, Tony Pawson and Ivan Dikic


Nature Structural & Molecular Biology

Spatial organization of intracellular communication: insights from imaging

Leif Dehmelt and Philippe I.H. Bastiaens


Nature Reviews Molecular Cell Biology