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Signal integration through blending, bolstering and bifurcating of intracellular information

Nature Structural & Molecular Biology volume 17, pages 653–658 (2010)Cite this article

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Abstract

A cell's response to its environment is often determined by signaling through the actions of enzyme cascades. The ability to organize these enzymes into multiprotein complexes allows for a high degree of fidelity, efficiency and spatial precision in signaling responses.

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Figure 1: Schematic representation of mechanisms of signal transduction.
Figure 2: Signal integration: the DISC1 scaffold integrates Wnt and cAMP signaling to coordinate neurodevelopment.
Figure 3: Ste5 coordinates signal activation in the yeast mating pathway.
Figure 4: Segregation of estrogen signaling events.

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Acknowledgements

We would like to thank members of the Scott lab for their critical review of this manuscript. This work was supported by the Foundation Leducq and by NIH grant DK54441 to J.D.S.

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  1. Department of Pharmacology, Howard Hughes Medical Institute, University of Washington, School of Medicine, Seattle, Washington, USA

    Catherine T Pawson & John D Scott

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Correspondence to John D Scott.

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Pawson, C., Scott, J. Signal integration through blending, bolstering and bifurcating of intracellular information. Nat Struct Mol Biol 17, 653–658 (2010). https://doi.org/10.1038/nsmb.1843

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