Focus
Focus on Tissue-resident leukocytes
- Focus
- October 2013 Volume 14, No 10
Immune cells are found in diverse nonlymphoid tissues where they patrol against infection and injury and help to maintain homeostasis. This month's Focus features five specially commissioned Reviews that discuss interactions and functions of tissue-resident leukocytes.
Editorial
Focus on Tissue-resident leukocytes
Immunity in the tissues - p977
doi:10.1038/ni.2722
Tissue-resident leukocytes contribute to tissue function and homeostasis as well as immune surveillance.
Full Text - Immunity in the tissues | PDF (160 KB) - Immunity in the tissues
Reviews
Focus on Tissue-resident leukocytes
The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells - pp978 - 985
William R Heath & Francis R Carbone
doi:10.1038/ni.2680
The skin is a highly complex organ and the main body barrier against pathogens and other environmental factors. Heath and Carbone outline many of the innate and adaptive immune cell types associated with the skin.
Abstract - The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells | Full Text - The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells | PDF (1,107 KB) - The skin-resident and migratory immune system in steady state and memory: innate lymphocytes, dendritic cells and T cells
Focus on Tissue-resident leukocytes
Tissue-resident macrophages - pp986 - 995
Luke C Davies, Stephen J Jenkins, Judith E Allen & Philip R Taylor
doi:10.1038/ni.2705
Macrophages populate tissues under homeostatic conditions. Taylor and colleagues discuss the heterogeneity of tissue macrophage populations, and how they contribute to tissue function and immune surveillance.
Abstract - Tissue-resident macrophages | Full Text - Tissue-resident macrophages | PDF (842 KB) - Tissue-resident macrophages
Focus on Tissue-resident leukocytes
Immune surveillance by the liver - pp996 - 1006
Craig N Jenne & Paul Kubes
doi:10.1038/ni.2691
The liver is important in mediating immunity to blood-borne infections. Jenne and Kubes review the liver as an immune organ and discuss the roles of liver-resident cells and their interactions with circulating immune cells.
Abstract - Immune surveillance by the liver | Full Text - Immune surveillance by the liver | PDF (1,088 KB) - Immune surveillance by the liver | Supplementary information
Focus on Tissue-resident leukocytes
Regulatory T cells in nonlymphoid tissues - pp1007 - 1013
Dalia Burzyn, Christophe Benoist & Diane Mathis
doi:10.1038/ni.2683
Regulatory T (Treg) cells modulate immune cell responses. Mathis and colleagues review the specialized roles played by tissue-specific Treg cells and reveal new functions that can be attributed to distinct Treg cell subsets.
Abstract - Regulatory T cells in nonlymphoid tissues | Full Text - Regulatory T cells in nonlymphoid tissues | PDF (536 KB) - Regulatory T cells in nonlymphoid tissues
Focus on Tissue-resident leukocytes
Innate and adaptive immune cells in the tumor microenvironment - pp1014 - 1022
Thomas F Gajewski, Hans Schreiber & Yang-Xin Fu
doi:10.1038/ni.2703
Tumors can evade immune system–mediated destruction despite expressing antigenic neoepitopes. Gajewski, Schreiber and Fu discuss how the tumor microenvironment harnesses innate and adaptive immune cell regulatory processes to promote tumor survival.
Abstract - Innate and adaptive immune cells in the tumor microenvironment | Full Text - Innate and adaptive immune cells in the tumor microenvironment | PDF (1,664 KB) - Innate and adaptive immune cells in the tumor microenvironment
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