Developed using diverse sources of histopathology images, biomedical text and over 1.17 million image–caption pairs, evaluated on a suite of 14 diverse benchmarks, a visual-language foundation model achieves state-of-the-art performance on a wide array of clinically relevant pathology tasks.

In an updated systematic review and meta-analysis, fixed-dose combination therapy using a polypill with at least one blood pressure-lowering drug and one lipid-lowering drug was found to reduce both incident cardiovascular disease and all-cause mortality.

Self-care interventions have the potential to improve health coverage for women while offering greater agency and autonomy, but only if certain barriers—such as stigma and cost—can be overcome.

In an interim analysis of a phase 1/2 trial, a heterologous prime boost vaccine comprised of a chimpanzee adenovirus and self-amplifying mRNA that encodes neoantigens derived from common oncogenic driver mutations in combination with immune checkpoint blockade was safe and elicited neoantigen-specific T cell responses in patients with advanced solid tumors.

In an updated systematic review and meta-analysis, fixed-dose combination therapy using a polypill with at least one blood pressure-lowering drug and one lipid-lowering drug was found to reduce both incident cardiovascular disease and all-cause mortality.

In a prospective cohort of Chinese participants aged 65 years and older, heatwaves doubled the risk of mortality, especially in adults with functional impairments and dependency on daily living activities.

In a phase Ib trial, neoadjuvant nivolumab or nivolumab/relatlimab prior to chemoradiotherapy were well tolerated and liquid biopsy analyses show that undetectable ctDNA was associated with longer survival.

Developed using diverse sources of histopathology images, biomedical text and over 1.17 million image–caption pairs, evaluated on a suite of 14 diverse benchmarks, a visual-language foundation model achieves state-of-the-art performance on a wide array of clinically relevant pathology tasks.

Pretrained using over 100,000 diagnostic histopathological slides across 20 major tissue types, a self-supervised model is shown to outperform existing baselines across various clinically relevant computational pathology tasks.

Deployment of mobile vaccination teams to remote communities in Sierra Leone substantially increased COVID-19 vaccine uptake, and could potentially be bundled with other health interventions.

Patients with carotid artery plaque that contain microplastics and nanoplastics were found to be at higher risk of cardiovascular events and mortality than those in whom the particles were not detected.

In rhesus macaques, treatment with an IL-15 superagonist and broad neutralizing antibodies led to durable suppression of viremia after discontinuation of antiretroviral therapy.

Women’s health can be improved by increasing the representation of women in leadership roles in science, medicine and public health.

In healthcare, many artificial intelligence models could be used in settings other than those for which they were approved. But such off-label use must include an empirical or mechanistic evaluation to ensure patient safety.