A systematic review and meta-analysis of studies covering 66 countries reported wide-ranging maternal, fetal and neonatal health harms associated with heat exposure, including increased risks of preterm birth, stillbirths, obstetric complications, congenital anomalies and gestational diabetes.

A randomized controlled trial involving people with psychosis who hear distressing voices reported that two different forms of AVATAR therapy, an intervention where voice-hearers engage with a digital avatar representing this distressing voice, reported further improvements in voice-related distress at 16 weeks but not at 28 weeks on top of standard of care.

An analysis of all available mpox virus sequences, including 10,670 sequences from 65 countries collected between 1958 and 2024, unveils the circulation pattern and spatiotemporal dynamics underlying the spread of the different viral clades.

Trauma and infections increase during war, while routine cancer care is disrupted, but telemedicine, AI chatbots and electronic health records can help.

A vascular cell atlas integrating single-cell data of 19 organs and tissues from 62 donors identifies angiotypic and organotypic characteristics of endothelial and mural cells.

The spatial single-cell multiomic atlas of the first trimester human placenta at molecular resolution provides a blueprint for future studies on early placental development and pregnancy.

A single-cell study integrating data from lung tissues from patients with fatal COVID-19 from Malawi, the United States and Europe identifies shared and distinct immune and inflammatory mechanisms of response.

In a mechanistic analysis of the SUMMIT trial that tested tirzepatide in patients with heart failure with preserved ejection fraction and obesity, treatment with this dual glucagon-like peptide-1 receptor and gastric inhibitory polypeptide agonist, as compared with placebo, reduced blood pressure and estimated circulatory volume–pressure overload, reduced systemic inflammation and mitigated cardiovascular and kidney injury.

Next-generation metagenomic testing increases the accuracy and sensitivity of the etiology of central nervous system infections in hospitalized patients.

In the dose-escalation part of the ongoing phase 1/2 LIBRA4 trial, patients with relapsed/refractory peripheral T cell lymphoma received T cell antigen receptor beta-chain constant domain 1 (TRBC1)-targeted chimeric antigen receptor T cell therapy, showing limited toxicity and encouraging preliminary clinical responses.

Post-war rationing in the UK in 1953 facilitated a natural experiment that now reveals that restricting sugar intake in early life reduces the risk of diabetes and hypertension.

As GLP-1 receptor agonists emerge as treatment options for conditions beyond diabetes and obesity, it becomes critical to understand how genetic, clinical and sociodemographic differences impact their effects on weight loss.

Two studies reveal high transmissibility and lethality of the viral isolate in animal models, and hint at potential drug susceptibility — but further analysis and ongoing surveillance of infections will be critical for public health.

The twentieth century saw unprecedented rises in life expectancy in high-income countries, but data suggest that this trend will not continue in the current century without radical interventions to slow biological aging.

In British South Asian women, a culturally adapted and community-informed cognitive behavioral therapy intervention led to higher early recovery rates than the usual treatment.

Growing momentum to transform the African regulatory landscape should enable 60% of the vaccines needed in Africa to be locally produced by 2040.