Despite increasing availability of pharmacotherapies, interventions targeting unhealthy lifestyle behaviors continue to be critically important in the prevention and management of cardiometabolic diseases—and should be reinforced by supportive environments and policy measures.

Citizen-science approaches can help challenge taboos around intimate health topics, amplify underrepresented voices and prioritize women’s involvement in health research; this Perspective considers the key challenges and ingredients for success.

Trauma and infections increase during war, while routine cancer care is disrupted, but telemedicine, AI chatbots and electronic health records can help.

In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key drivers of young-onset T2D diagnosis and faster progression to diabetes-related complications.

A new AI generative model leverages the use of synthetic images to effectively augment existing datasets, boosting performance across multiple medical applications

Partitioning clustering based on clinical variables applied to multiple patient cohorts identifies two subtypes of metabolic dysfunction-associated steatotic liver disease with different associations to hepatic and cardiovascular outcomes.

The application of partitioned polygenic scores to data from cohorts of patients identifies two distinct subtypes of MASLD with different cardiometabolic risk profiles.

Whole-brain anatomical and activity surveys identify the lateral hypothalamus as a key driver of recovery from spinal cord injury, leading to a deep brain stimulation therapy that augments the recovery of walking in humans.

In a cohort of 50,556 South Asian individuals, partitioned polygenic scores helped identify genetic susceptibility to insulin deficiency and unfavorable fat distribution as key drivers of young-onset T2D diagnosis and faster progression to diabetes-related complications.

The spatial single-cell multiomic atlas of the first trimester human placenta at molecular resolution provides a blueprint for future studies on early placental development and pregnancy.

Health data should measure the complexity of women’s lives.

The updated Declaration of Helsinki empowers ethics committees to require community engagement and equitable partnerships

Interim results from a large, ongoing study shows that genomic newborn screening identifies treatable conditions that would be missed by standard tests.

According to a large international study, Internet use among adults 50 or more years of age correlates with reduced depressive symptoms, increased life satisfaction and improved self-reported health.

A large-scale genomic analysis reveals associations between body mass index and certain driver mutations in various cancer types, particularly lung adenocarcinoma.

Post-war rationing in the UK in 1953 facilitated a natural experiment that now reveals that restricting sugar intake in early life reduces the risk of diabetes and hypertension.