The infectious viral load of SARS-CoV-2 Omicron is lower than that of Delta in symptomatic breakthrough infections of recipients of two doses of a COVID-19 vaccine, suggesting that the higher transmission of Omicron is not linked to higher infectious viral load.

The analysis of large transplant cohorts reveals that in the context of liver transplant, but not kidney transplant, both the donor and the recipient type 2 diabetes polygenic risk scores influence the risk of developing post-transplant diabetes.

Two studies incorporating data from millions of patients highlight the need for consistent screening and access to supportive care.

Evidence from recent armed conflicts shows that a long-term approach is needed to support health infrastructure and protect the vulnerable.

The infectious viral load of SARS-CoV-2 Omicron is lower than that of Delta in symptomatic breakthrough infections of recipients of two doses of a COVID-19 vaccine, suggesting that the higher transmission of Omicron is not linked to higher infectious viral load.

The analysis of large transplant cohorts reveals that in the context of liver transplant, but not kidney transplant, both the donor and the recipient type 2 diabetes polygenic risk scores influence the risk of developing post-transplant diabetes.

Intravitreal administration of the antisense oligonucleotide sepofarsen in patients with Leber congenital amaurosis type 10 showed a manageable safety profile, ocular adverse events being dose dependent, and achieved meaningful improvements of visual function.

In the first SARS-CoV-2 challenge study in humans, 36 young, healthy adult participants were intranasally inoculated with virus and monitored for productive infection, symptoms, virus kinetics, antibody response and safety in a controlled setting.

Preclinical data and results from a phase 1 and 2 trial demonstrate preliminary safety and efficacy of topical gene therapy for recessive dystrophic epidermolysis bullosa

A large-scale population analysis quantifies the burden of mental illness and self-harm events in patients diagnosed with the most common adult cancers and highlights opportunities for advancing patient care.

Many governments are rolling back restrictions, but the pandemic will end only with a renewed focus on equitable distribution of vaccines and therapeutics, responsive public health plans, and policies to protect the vulnerable.

Trastuzumab deruxtecan performed better than trastuzumab emtansine in patients with pretreated HER2-positive metastatic breast cancer, but careful safety monitoring will be needed in the clinical setting.

Data reveal an increased risk of diabetes in the months after acute COVID-19 infection – which could have implications for stretched public health systems.

Window-of-opportunity trials, during which patients receive short-duration pre-surgical therapies, provide a platform for understanding the therapies’ mechanisms of action, but will require a paradigm shift in trial design, specimen collection and analysis.