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Role of non-coding RNAs in neuroblastoma

Cancer Gene Therapy volume 30, pages 1190–1208 (2023)Cite this article

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Abstract

Neuroblastoma is known as the most prevalent extracranial malignancy in childhood with a neural crest origin. It has been widely accepted that non-coding RNAs (ncRNAs) play important roles in many types of cancer, including glioma and gastrointestinal cancers. They may regulate the cancer gene network. According to recent sequencing and profiling studies, ncRNAs genes are deregulated in human cancers via deletion, amplification, abnormal epigenetic, or transcriptional regulation. Disturbances in the expression of ncRNAs may act either as oncogenes or as anti-tumor suppressor genes, and can lead to the induction of cancer hallmarks. ncRNAs can be secreted from tumor cells inside exosomes, where they can be transferred to other cells to affect their function. However, these topics still need more study to clarify their exact roles, so the present review addresses different roles and functions of ncRNAs in neuroblastoma.

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Fig. 1: Role of miRNAs and miRNA inhibitors in NB.
Fig. 2: Classification of long-non-coding RNAs based on the localization within the genome.
Fig. 3: Generation of three types of circular RNA.
Fig. 4: Effect of extracellular vesicles on growth of tumor cells and their metastatic potential in NB [116].

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Data availabilty

The primary data for this study is available from the authors on request.

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Authors and Affiliations

  1. Department of Internal Medicine, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Ali Arash Anoushirvani

  2. Neurology Department, Kashan University of Medical Sciences, Kashan, Iran

    Arezoo Jafarian Yazdi

  3. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Sanaz Amirabadi

  4. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University, Kashan, Iran

    Sahar Ahmadi Asouri, Rana Shafabakhsh & Hamed Mirzaei

  5. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

    Amirhossein Sheida, Maryam Sadat Hosseini Khabr & Leila Kalantari

  6. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran

    Amirhossein Sheida & Maryam Sadat Hosseini Khabr

  7. ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran

    Ameneh Jafari

  8. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Ameneh Jafari

  9. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Seyed Saeed Tamehri Zadeh

  10. Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa

    Michael R. Hamblin

  11. Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

    Sayyed Alireza Talaei Zavareh

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  1. Ali Arash Anoushirvani
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  2. Arezoo Jafarian Yazdi
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  13. Hamed Mirzaei
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Contributions

HM involved in conception, design, statistical analysis and drafting of the manuscript. AAA, AJY, SA, SAA, RS, LK, AS, MSHK, AJ, SSTZ, MRH, and SATZ contributed in data collection and manuscript drafting. All authors approved the final version for submission.

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Correspondence to Leila Kalantari, Sayyed Alireza Talaei Zavareh or Hamed Mirzaei.

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Anoushirvani, A.A., Jafarian Yazdi, A., Amirabadi, S. et al. Role of non-coding RNAs in neuroblastoma. Cancer Gene Ther 30, 1190–1208 (2023). https://doi.org/10.1038/s41417-023-00623-0

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  • DOI: https://doi.org/10.1038/s41417-023-00623-0

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