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CNS cancer is a type of cancer that forms in the central nervous system. It includes brain stem glioma, craniopharyngioma, medulloblastoma and meningioma.
In an interim analysis of an ongoing phase 1 trial of CAR T cells targeting EGFR and IL13Ra2 in patients with multifocal, recurrent glioblastoma, intrathecal delivery is feasible and well tolerated, with some reductions seen in tumor size.
Bou-Nassif et al. develop a smartphone app using AI and stimulated Raman histology to differentiate pituitary adenomas from normal tissue in real-time during surgery. Prospective validation on 40 patients shows high sensitivity and specificity, with an external validation on 40 additional adenoma tumors.
Zhao et al. identified lymphatic endothelial-like cells in glioblastoma and demonstrated their role in promoting tumour growth through increased glioblastoma cholesterol metabolism.
A validated biomarker risk score based on the expression of 34 genes improves risk stratification of patients with meningioma, including prediction of post-operative radiotherapy benefit.
Maas et al. identify an inflammatory, immunosuppressive phenotype in neutrophils that accumulates in brain malignancies, and show that this tumour-promoting neutrophil activation is driven by the brain tumour microenvironment.