●Primordial germ-cell development: the zebrafish perspective. Raz, E. Nature Reviews Genetics September (2003).

●Mechanisms of sarcoma. Helman, L. J. & Meltzer, P. Nature Reviews Cancer September (2003).

●Defensins: antimicrobial peptides of innate immunity. Ganz, T. Nature Reviews Immunology September (2003).

●The development and regulation of gene repair. Liu, L., Parekh-Olmedo, H. & Kmiec, E. B. Nature Reviews Genetics September (2003).

●Unfolding the toxicity of cholesterol. Zhang, K. & Kaufman, R. J. Nature Cell Biology September (2003). This News and Views article discusses a recent study showing that depletion of calcium stores in the endoplasmic reticulum, which leads to activation of the unfolded protein response and subsequent cell death, is a key event in cholesterol-induced macrophage apoptosis.

●Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Filbin, M. T. Nature Reviews Neuroscience September (2003).

●p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Kumar, S., Boehm, J. & Lee, J. C. Nature Reviews Drug Discovery September (2003).

●The trials and tribulations of producing the first genetically engineered drug. Johnson, I. S. Nature Reviews Drug Discovery September (2003).

●Regulation of the immune system by helminth parasites. Maizels, R. M. & Yazdanbakhsh, M. Nature Reviews Immunology September (2003).

●14-3-3 proteins in the nervous system. Berg, D., Holzmann, C. & Riess, O. Nature Reviews Neuroscience September (2003).

●Small interfering RNAs in the radar of the interferon system. Moss, E. G. Nature Cell Biology September (2003).

●Aspirin, ubiquitin and cancer. Wilkinson, K. D. Nature 14 August (2003). A News and Views piece on recent findings that the deubiquitylating and tumour-suppressor protein CYLD negatively regulates the nuclear factor κB signalling pathway. The anti-inflammatory drug aspirin prevents NFκB-responsive gene activation and inhibition of apoptosis caused by CYLD loss.