●Focus on cell polarity, including: Polarized epithelial membrane traffic: conservation and plasticity. Mostov, K., Su, T. & ter Beest, M. Nature Cell Biology April (2003).

●Patterning cell types in the dorsal spinal cord: what the mouse mutants say. Caspary, T. & Anderson, K. V. Nature Reviews Neuroscience April (2003).

●Issues and progress with protein kinase inhibitors for cancer treatment. Dancey, J. & Sausville, E. A. Nature Reviews Drug Discovery April (2003).

●Numerous roles for PI3K in lymphocyte development, differentiation and activation. Okkenhaug, K. & Vanhaesebroeck, B. Nature Reviews Immunology April (2003).

●Senescence, apoptosis and therapy — cutting the lifelines of cancer. Schmitt, C. A. Nature Reviews Cancer April (2003).

●New technologies to assess genotype–phenotype relationships. Bochner, B. R. Nature Reviews Genetics April (2003).

●ER-mediated phagocytosis: a new membrane for new functions. Desjardins, M. Nature Reviews Immunology April (2003).

●Between genotype and phenotype: protein chaperones and evolvability. Rutherford, S. L. Nature Reviews Genetics April (2003).

●The role of receptor diffusion in the organization of the postsynaptic membrane. Choquet, D. & Triller, A. Nature Reviews Neuroscience April (2003).

●Neurotrophins and their receptors: a convergence point for many signalling pathways. Chao, M. V. Nature Reviews Neuroscience April (2003).

●Focus on early detection of cancer.Nature Reviews Cancer April (2003). A special issue that examines early detection — an approach that could be an effective and promising way to reduce the increasing burden of cancer.

●Proteomic applications for the early detection of cancer. Wulfkuhle, J., Liotta, L. & Petricoin, E.

●The power and the promise of DNA methylation markers. Laird, P. W.