The challenges of in silico biology. Palsson, B. Nature Biotechnology November (2000) .

Insight on Ageing.

Nature 5 November (2000).

● The many substrates and functions of ATM.

Kastan, M. B. & Lim, D. S. Nature Reviews Molecular Cell Biology December (2000).

● Small but mighty keepers.

Andouette, A. Nature 2 November (2000).

A News and Views article on small but vital RNAs that control the development of worms and flies from larvae into adults.

p63 and p73: p53 mimics, menaces and more.

Yang, A. & McKeon, F. Nature Reviews Molecular Cell Biology December (2000).

The past within us.

Renfrew, C., Forster, P. & Hurles, M. Nature Genetics November (2000).

A News and Views article on a recent, comprehensive study of Y-chromosome variation that sheds light on human evolution and on present-day male infertility .

● Telomere states and cell fates.

Blackburn, E. H. Nature 2 November (2000).

● Guarding against mutation.

Kolodner, R. D. Nature 12 October (2000).

This News and Views reports how the elucidation of the crystal structure of a key DNA-repair protein offers insights into the first step of the DNA-repair process.

● Regenerating the damaged central nervous system.

Horner, P. J. & Gage, F. H. Nature 26 October (2000) .

● Accessory factors in clathrin-dependent synaptic vesicle endocytosis .

Slepnev, V. I. & De Camilli, P. Nature Reviews Neuroscience December (2000).

This review summarizes advances in our understanding of clathrin-mediated endocytosis as revealed by genetic, biochemical and structural studies.