Transplantation

Transplantation is the procedure of transferring a tissue or organ from one individual to another or from one site to another within a single individual. The transplanted tissue or organ replaces damaged or absent tissue, and is functional in the recipient.

Latest Research and Reviews

  • Research | | open

    Organs from donors with transmissible viral infections, such as hepatitis C virus (HCV), are not offered for transplantation due to a high risk of transmission. Here, Galasso et al. develop a method for treatment of HCV-infected human donor lungs that is safe and prevents HCV transmission in the pig model.

    • Marcos Galasso
    • , Jordan J. Feld
    • , Yui Watanabe
    • , Mauricio Pipkin
    • , Cara Summers
    • , Aadil Ali
    • , Robert Qaqish
    • , Manyin Chen
    • , Rafaela V. P. Ribeiro
    • , Khaled Ramadan
    • , Layla Pires
    • , Vanderlei S. Bagnato
    • , Cristina Kurachi
    • , Vera Cherepanov
    • , Gray Moonen
    • , Anajara Gazzalle
    • , Thomas K. Waddell
    • , Mingyao Liu
    • , Shaf Keshavjee
    • , Brian C. Wilson
    • , Atul Humar
    •  & Marcelo Cypel
  • Reviews |

    The complement system has a key role in inflammatory reactions that occur before, during and after transplantation. Here, the authors discuss this role and highlight current and future strategies to regulate complement activation and potentially improve outcomes in kidney transplantation.

    • Ali-Reza Biglarnia
    • , Markus Huber-Lang
    • , Camilla Mohlin
    • , Kristina N. Ekdahl
    •  & Bo Nilsson
  • Reviews |

    Cells can be transplanted into the body to both repair injured or diseased tissue and restore tissue function. This Review discusses how biomaterial design strategies can be used to improve cell survival, influence the fate of transplanted cells, and favourably manipulate the host microenvironment and the immune system.

    • Nikolaos Mitrousis
    • , Ana Fokina
    •  & Molly S. Shoichet

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