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| Open AccessThe discovery of novel heat-stable keratinases from Meiothermus taiwanensis WR-220 and other extremophiles
- Wan-Ling Wu
- , Mei-Yi Chen
- & Shih-Hsiung Wu
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| Open AccessCellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2
- Manuel Johanns
- , Pascale Lemoine
- & Patrick Henriet
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| Open AccessHigh-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway
- Seiji Ishii
- , Kenji Fukui
- & Takato Yano
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| Open AccessDiscovery of a novel conformational equilibrium in urokinase-type plasminogen activator
- Tobias Kromann-Hansen
- , Eva Louise Lange
- & Peter A. Andreasen
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| Open AccessPH-Dependent Enantioselectivity of D-amino Acid Oxidase in Aqueous Solution
- Qingju Liu
- , Li Chen
- & Yujian He
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| Open AccessDynamics and ligand-induced conformational changes in human prolyl oligopeptidase analyzed by hydrogen/deuterium exchange mass spectrometry
- Alexandra Tsirigotaki
- , Roos Van Elzen
- & Anastassios Economou
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| Open AccessThe Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach
- Shilvi Joshi
- , Lang Chen
- & Aaron M. LeBeau
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| Open AccessOverexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer’s disease
- Archontia Kaminari
- , Nikolas Giannakas
- & Effie C. Tsilibary
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| Open AccessThe role of Lon-mediated proteolysis in the dynamics of mitochondrial nucleic acid-protein complexes
- Nina Kunová
- , Gabriela Ondrovičová
- & Vladimír Pevala
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| Open AccessSerine protease SP105 activates prophenoloxidase in Asian corn borer melanization, and is regulated by serpin-3
- Yuan Chu
- , Fang Hong
- & Chunju An
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Article
| Open AccessThe toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae
- Zatul-’Iffah Abu Hasan
- , Helen Williams
- & R. Elwyn Isaac
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| Open AccessThe Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss
- Zhiwei Zhang
- , Yae Hu
- & Qingyu Wu
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| Open AccessRational Design of Protein C Activators
- Sergio Barranco-Medina
- , Mary Murphy
- & Nicola Pozzi
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Article
| Open AccessExtracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis
- Chiara Dianzani
- , Elena Bellavista
- & Michele Mishto
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Article
| Open AccessMeprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling
- Philipp Arnold
- , Inga Boll
- & Christoph Becker-Pauly
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Article
| Open AccessCharacterization of the CD177 interaction with the ANCA antigen proteinase 3
- Uwe Jerke
- , Stephen F. Marino
- & Ralph Kettritz
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Article
| Open AccessA hydrophobic patch surrounding Trp154 in human neuroserpin controls the helix F dynamics with implications in inhibition and aggregation
- Mohammad Farhan Ali
- , Abhinav Kaushik
- & Mohamad Aman Jairajpuri
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Article
| Open AccessHighly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families
- Marcin Poreba
- , Aleksandra Szalek
- & Marcin Drag
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| Open AccessUnusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease
- Dirk Hubmacher
- , Michael Schneider
- & Suneel S. Apte
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Article
| Open AccessNeutrophil elastase cleavage of the gC1q domain impairs the EMILIN1-α4β1 integrin interaction, cell adhesion and anti-proliferative activity
- Orlando Maiorani
- , Eliana Pivetta
- & Paola Spessotto
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Article
| Open AccessHarnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo
- Eitan Wong
- , Tal Cohen
- & Irit Sagi
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Article
| Open AccessFunctional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome
- Muhammad Faheem
- , Diogo Martins-de-Sa
- & João Alexandre R. G. Barbosa
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| Open AccessCellular aspartyl proteases promote the unconventional secretion of biologically active HIV-1 matrix protein p17
- Francesca Caccuri
- , Maria Luisa Iaria
- & Arnaldo Caruso
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| Open AccessCharacterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1
- Stéphane Pautus
- , Mouad Alami
- & Delphine Borgel
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| Open AccessChikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease’s active site cysteine residue
- Kai Rausalu
- , Age Utt
- & Andres Merits
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| Open AccessQuantitative analysis of protease recognition by inhibitors in plasma using microscale thermophoresis
- T. Dau
- , E. V. Edeleva
- & D. E. Jenne
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| Open AccessControl of ADAM17 activity by regulation of its cellular localisation
- Inken Lorenzen
- , Juliane Lokau
- & Stefan Düsterhöft
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| Open AccessCross-inhibition of pathogenic agents and the host proteins they exploit
- Leeor Zilbermintz
- , William Leonardi
- & Mikhail Martchenko
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Article
| Open AccessBithionol blocks pathogenicity of bacterial toxins, ricin and Zika virus
- William Leonardi
- , Leeor Zilbermintz
- & Mikhail Martchenko
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Article
| Open AccessSENP1 Is a Crucial Regulator for Cell Senescence through DeSUMOylation of Bmi1
- Nansong Xia
- , Juan Cai
- & Yong Zuo
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Article
| Open AccessNeprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney
- Oliver Domenig
- , Arndt Manzel
- & Marko Poglitsch
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Article
| Open AccessStructural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family
- Jean-François Trempe
- , Klára Grantz Šašková
- & Kalle Gehring
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| Open AccessExactin: A specific inhibitor of Factor X activation by extrinsic tenase complex from the venom of Hemachatus haemachatus
- Vallerinteavide Mavelli Girish
- & R. Manjunatha Kini
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| Open AccessERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing
- Hanna Chen
- , Lenong Li
- & Marlene Bouvier
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| Open AccessAddressing proteolytic efficiency in enzymatic degradation therapy for celiac disease
- Martial Rey
- , Menglin Yang
- & David C. Schriemer
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| Open AccessEffects of induction and inhibition of matrix cross-linking on remodeling of the aqueous outflow resistance by ocular trabecular meshwork cells
- Yong-Feng Yang
- , Ying Ying Sun
- & Kate E. Keller
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Article
| Open AccessMitochondrial cereblon functions as a Lon-type protease
- Kosuke Kataoka
- , China Nakamura
- & Naoya Sawamura
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| Open AccessBilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity
- Linda Cerofolini
- , Sabrina Amar
- & Gregg B. Fields
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| Open AccessEvaluation of physiological risk factors, oxidant-antioxidant imbalance, proteolytic and genetic variations of matrix metalloproteinase-9 in patients with pressure ulcer
- Khlifi Latifa
- , Sahli Sondess
- & Miled Abdelhedi
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Article
| Open AccessHigh-speed atomic force microscopy reveals strongly polarized movement of clostridial collagenase along collagen fibrils
- Takahiro Watanabe-Nakayama
- , Masahiro Itami
- & Hiroki Konno
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| Open Accessβ-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice
- Weihong Ren
- , Yan Liu
- & Jie Du
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| Open AccessPhosphorylation of the C-terminal tail of proteasome subunit α7 is required for binding of the proteasome quality control factor Ecm29
- Prashant S. Wani
- , Anjana Suppahia
- & Jeroen Roelofs
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Article
| Open AccessImproved catalytic efficiency, thermophilicity, anti-salt and detergent tolerance of keratinase KerSMD by partially truncation of PPC domain
- Zhen Fang
- , Juan Zhang
- & Jian Chen
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| Open AccessSingle Cell Proteolytic Assays to Investigate Cancer Clonal Heterogeneity and Cell Dynamics Using an Efficient Cell Loading Scheme
- Yu-Chih Chen
- , Yu-Heng Cheng
- & Euisik Yoon
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| Open AccessDistinct properties of proteases and nucleases in the gut, salivary gland and saliva of southern green stink bug, Nezara viridula
- Purushottam R. Lomate
- & Bryony C. Bonning
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| Open AccessAccumulation of human full-length tau induces degradation of nicotinic acetylcholine receptor α4 via activating calpain-2
- Yaling Yin
- , Yali Wang
- & Jian-Zhi Wang
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| Open AccessTwo-Photon Enzymatic Probes Visualizing Sub-cellular/Deep-brain Caspase Activities in Neurodegenerative Models
- Linghui Qian
- , Cheng-Wu Zhang
- & Shao Q. Yao
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| Open AccessBridging the gap: heparan sulfate and Scube2 assemble Sonic hedgehog release complexes at the surface of producing cells
- P. Jakobs
- , P. Schulz
- & K. Grobe
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Article
| Open AccessDevelopment of a quantitative fluorescence-based ligand-binding assay
- Conor J. Breen
- , Mathilde Raverdeau
- & H. Paul Voorheis