A non-common-path interferometric scheme enables holographic detection of single proteins of mass 90 kDa and estimation of single-protein polarizability.
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References
Young, G. & Kukura, P. Annu. Rev. Phys. Chem. 70, 301–322 (2019).
Taylor, R. W. & Sandoghdar, V. Nano Lett. 19, 4827–4835 (2019).
Piliarik, M. & Sandoghdar, V. Nat. Commun. 5, 4495 (2014).
Ortega Arroyo, J. et al. Nano Lett. 14, 2065–2070 (2014).
Young, G. et al. Science 360, 423–427 (2018).
Thiele, J. C., Pfitzner, E. & Kukura, P. Nat. Photon. https://doi.org/10.1038/s41566-024-01405-2 (2024).
Bian, K. et al. Nat. Rev. Methods Primers 1, 36 (2021).
Yu, D. et al. Nat. Rev. Methods Primers 1, 83 (2021).
Anker, J. N. et al. Nat. Mater. 7, 442–453 (2008).
Howorka, S. & Siwy, Z. Chem. Soc. Rev. 38, 2360–2384 (2009).
Squires, A. H., Lavania, A. A., Dahlberg, P. D. & Moerner, W. E. Nano Lett. 19, 4112–4117 (2019).
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Hsieh, CL. Single protein imaging with holography. Nat. Photon. 18, 303–304 (2024). https://doi.org/10.1038/s41566-024-01407-0
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DOI: https://doi.org/10.1038/s41566-024-01407-0
