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The nervous system consists of the central nervous system (brain and spinal cord) and the peripheral nervous system (motor nerves, sensory nerves, cranial and spinal nerves, autonomic ganglia, and plexuses).
The authors report two new engineered AAV capsids that efficiently deliver genes throughout the adult central and peripheral nervous systems after intravenous administration. Complementing these capsids is an AAV toolbox that enables cell morphology and genetic manipulation studies of defined neural cell types in transgenic or wild-type animals.
This protocol describes how to use the paradigm for social transmission of food preference in rats to assess recent and remote associative olfactory memory and underlying processes, including encoding, consolidation, retrieval and forgetting.
Disruption of retinal direction selectivity reveals both peripheral and central computations contributing to direction selectivity in mouse visual cortex. These mechanisms work together to better encode motion directions and speeds.