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| Open AccessAmino acid metabolism in tumor biology and therapy
- Jie Chen
- , Likun Cui
- & Sheng Xu
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| Open AccessIFITM3 promotes glioblastoma stem cell-mediated angiogenesis via regulating JAK/STAT3/bFGF signaling pathway
- Zhangsheng Xiong
- , Xiangdong Xu
- & Yang Liu
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| Open AccessActivated hepatic stellate cell-derived Bmp-1 induces liver fibrosis via mediating hepatocyte epithelial-mesenchymal transition
- Sizhe Wan
- , Xianzhi Liu
- & Bin Wu
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| Open AccessCortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity
- Yiwei Feng
- , Lishan Lin
- & Zhong Pei
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| Open AccessEpigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses
- Shuang Ding
- , Haibin Liu
- & Wuxiang Guan
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| Open AccessE3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis
- Yingjie Huang
- , Tao Chen
- & Yong Li
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| Open AccessThe heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
- Yangyang Feng
- , Ming Zhao
- & Chu-Xia Deng
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| Open AccessPalmitate induces integrated stress response and lipoapoptosis in trophoblasts
- Prakash Kumar Sahoo
- , Chandan Krishnamoorthy
- & Sathish Kumar Natarajan
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| Open AccessFBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression
- Jing Ji
- , Aixin Jing
- & Bin Liu
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| Open AccessAmyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma
- Jingzhi Li
- , Ming Guo
- & Yongheng Chen
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Article
| Open AccessAntitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models
- Gonzalo Rodriguez-Berriguete
- , Rathi Puliyadi
- & Geoff S. Higgins
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| Open AccessDeath receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis
- Jianbo Liu
- , Kaixuan Liu
- & Bing Xue
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| Open AccessEvaluation of apoptosis stimulating protein of TP53-1 (ASPP1/PPP1R13B) to predict therapy resistance and overall survival in acute myeloid leukemia (AML)
- Marcus M. Schittenhelm
- , Max Kaiser
- & Kerstin M. Kampa-Schittenhelm
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| Open AccessCRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α
- Xin Fu
- , Qian Zhang
- & Qiuping Dong
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| Open AccessCharacterizing influence of rCHOP treatment on diffuse large B-cell lymphoma microenvironment through in vitro microfluidic spheroid model
- Matthew R. Sullivan
- , Rachel P. White
- & Tania Konry
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Article
| Open AccessVaricella zoster virus glycoprotein E facilitates PINK1/Parkin-mediated mitophagy to evade STING and MAVS-mediated antiviral innate immunity
- Soo-Jin Oh
- , Je-Wook Yu
- & Ok Sarah Shin
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| Open AccessNovel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer
- Qingyun Zhu
- , Qiuzi Dai
- & Yuyang Jiang
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| Open AccessTargeting NEDD8 suppresses surgical stress-facilitated metastasis of colon cancer via restraining regulatory T cells
- Yi Jiang
- , Shenjia Gao
- & Wankun Chen
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Article
| Open AccessNuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ
- Yanxiong Yu
- , Mohammad S. Farooq
- & Elke Burgermeister
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Article
| Open AccessUBE2O reduces the effectiveness of interferon-α via degradation of IFIT3 in hepatocellular carcinoma
- Heng Li
- , Yao Liu
- & Lian-Xin Liu
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Review Article
| Open AccessWWP1 E3 ligase at the crossroads of health and disease
- Abhayananda Behera
- & Aramati Bindu Madhava Reddy
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Article
| Open AccessRNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response
- Jinqiu Feng
- , Shufang Ye
- & Yingyu Chen
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Article
| Open AccessUSP7 inhibits the progression of nasopharyngeal carcinoma via promoting SPLUNC1-mediated M1 macrophage polarization through TRIM24
- Huai Liu
- , Ling Tang
- & Pan Chen
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Article
| Open Accessp140Cap modulates the mevalonate pathway decreasing cell migration and enhancing drug sensitivity in breast cancer cells
- Giorgia Centonze
- , Dora Natalini
- & Paola Defilippi
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Article
| Open AccessAtypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice
- Atsuhiko Ichimura
- , Yuu Miyazaki
- & Hiroshi Takeshima
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Article
| Open AccessGss deficiency causes age-related fertility impairment via ROS-triggered ferroptosis in the testes of mice
- Haixia Zhu
- , Yin Cheng
- & Bin Wu
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Article
| Open AccessAirway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling
- Zhangchu Jin
- , Zhehua Shao
- & Fugui Yan
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Article
| Open AccessSingle-cell transcriptional landscape of long non-coding RNAs orchestrating mouse heart development
- Thaís A. R. Ramos
- , Sebastián Urquiza-Zurich
- & Vinicius Maracaja-Coutinho
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Article
| Open AccessImatinib induces ferroptosis in gastrointestinal stromal tumors by promoting STUB1-mediated GPX4 ubiquitination
- Xiangfei Sun
- , Qiang Zhang
- & Kuntang Shen
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Article
| Open AccessUpregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/β-catenin signaling activation
- Changlin Zhang
- , Lixiang Liu
- & Tian Li
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Article
| Open AccessFasting regulates mitochondrial function through lncRNA PRKCQ-AS1-mediated IGF2BPs in papillary thyroid carcinoma
- Xiaoping Zhang
- , Yong Zhong
- & Zhongwei Lv
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Article
| Open AccessPDIA6, which is regulated by TRPM2-AS/miR-424-5p axis, promotes endometrial cancer progression via TGF-beta pathway
- Pengling Wang
- , Tianli Zhang
- & Xingsheng Yang
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Article
| Open AccessThe chromatin remodeling protein BRG1 regulates HSC-myofibroblast differentiation and liver fibrosis
- Yuwen Zhu
- , Aoqi Kang
- & Nan Li
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Article
| Open AccessHypoxia-induced activation of NDR2 underlies brain metastases from Non-Small Cell Lung Cancer
- Jérôme Levallet
- , Tiphaine Biojout
- & Guénaëlle Levallet
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Article
| Open AccessThe TRIM21-FOXD1-BCL-2 axis underlies hyperglycaemic cell death and diabetic tissue damage
- Wenwen Cheng
- , Cifeng Cai
- & Zhiyong Liao
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Article
| Open AccessActivation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis
- Lin Xie
- , Ye Cheng
- & Xiangchen Gu
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Article
| Open AccessInhibition of demethylase by IOX1 modulates chromatin accessibility to enhance NSCLC radiation sensitivity through attenuated PIF1
- Qian Li
- , Kexin Qin
- & Lijun Wu
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Article
| Open AccessInhibition of PFKP in renal tubular epithelial cell restrains TGF-β induced glycolysis and renal fibrosis
- Shu Yang
- , Han Wu
- & Zhen Liang
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Article
| Open AccessThe aryl hydrocarbon receptor controls mesenchymal stromal cell-mediated immunomodulation via ubiquitination of eukaryotic elongation factor-2 kinase
- Enkhmaa Lkhagva-Yondon
- , Myeong Seong Seo
- & Myung-Shin Jeon
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Article
| Open Accessm6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation
- Baoxiang Chen
- , Yuntian Hong
- & Congqing Jiang
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Article
| Open AccessCancer CD39 drives metabolic adaption and mal-differentiation of CD4+ T cells in patients with non-small-cell lung cancer
- Ying Wang
- , Mengdi Liu
- & Zhenke Wen
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Article
| Open AccessGp78 deficiency in hepatocytes alleviates hepatic ischemia-reperfusion injury via suppressing ACSL4-mediated ferroptosis
- Changbiao Li
- , Yichao Wu
- & Xiao Xu
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Article
| Open AccessNuclear isoform of RAPH1 interacts with FOXQ1 to promote aggressiveness and radioresistance in breast cancer
- Qun Liu
- , Yu Cao
- & Peng Xing
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Article
| Open AccessPhosphorylation of MIF by PIP4K2a is necessary for cilia biogenesis
- Lu Zhang
- , Hongbing Zhang
- & Xiaogang Li
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Article
| Open AccessDeletion of Mettl3 in mesenchymal stem cells promotes acute myeloid leukemia resistance to chemotherapy
- Xinai Liao
- , Danni Cai
- & Huifang Huang
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Article
| Open AccessSOX2 promotes vasculogenic mimicry by accelerating glycolysis via the lncRNA AC005392.2-GLUT1 axis in colorectal cancer
- Shimiao Huang
- , Xuan Wang
- & Haoxuan Zheng
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Article
| Open AccessOverexpressed Gαi1 exerts pro-tumorigenic activity in nasopharyngeal carcinoma
- De-Pei Yin
- , Huanle Zhang
- & Ji-Sheng Liu
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Article
| Open AccessMiR-1246b, a novel miRNA molecule of extracellular vesicles in bronchoalveolar lavage fluid, promotes nodule growth through FGF14 in patients with lung cancer
- Jing Huang
- , Ming Ding
- & Pingsheng Chen
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Article
| Open AccessThe C-type lectin COLEC10 is predominantly produced by hepatic stellate cells and involved in the pathogenesis of liver fibrosis
- Mengfan Zhang
- , Yang Jing
- & Jianzhuang Ren