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The health sciences study all aspects of health, disease and healthcare. This field of study aims to develop knowledge, interventions and technology for use in healthcare to improve the treatment of patients.
This protocol describes how to make and use a gelatin-based hypoxia-inducible hydrogel to inject or embed tissue or cells. This enables the cellular responses to controllable hypoxic gradients to be assessed in vitro and in vivo, e.g., in mice.
Multiple myeloma — a malignancy of terminally differentiated plasma cells — is the second most common haematological malignancy. This Primer by Kumar et al. highlights the mechanisms and epidemiology of multiple myeloma, and describes how updates to the diagnostic criteria have impacted patient management.
The cysteine protease CPR-4, a cathepsin B homologue, is identified as a radiation-induced bystander effect (RIBE) factor in nematodes in response to ultraviolet or ionizing radiation, and causes inhibition of cell death and increased embryonic lethality.
In vivo CRISPR screening reveals that loss of Ptpn2 increases the response of tumour cells to immunotherapy and increases IFNγ signalling, suggesting that PTPN2 inhibition may potentiate the effect of immunotherapies that invoke an IFNγ response.
Cancer evolution is central to poor outcomes of cancer therapies, enabling tumour progression and the acquisition of drug resistance. Joint efforts of evolutionary biologists, oncologists and cancer researchers are necessary to understand the principles of cancer evolution and to derive therapeutic strategies that can control it.