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| Open AccessGasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation
- Fangyuan Long
- , Xuecui Wei
- & Xu Chen
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Article
| Open AccessTRIB3 promotes malignancy of head and neck squamous cell carcinoma via inhibiting ferroptosis
- Li Chen
- , Wanzun Lin
- & Lin Kong
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Review Article
| Open AccessmTOR pathway occupies a central role in the emergence of latent cancer cells
- Kseniia V. Aleksandrova
- , Mikhail L. Vorobev
- & Irina I. Suvorova
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Article
| Open AccessKEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC
- Jinghan Li
- , Daiwang Shi
- & Hong-Xu Liu
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| Open AccessSPOP point mutations regulate substrate preference and affect its function
- Yanran Deng
- , Wenhao Ding
- & Ligong Lu
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Article
| Open AccessConcurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRASG12D-mutant pancreatic ductal adenocarcinoma
- Yan Qin Tan
- , Bowen Sun
- & Vijay Pandey
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Article
| Open AccessmiR-184 represses β-catenin and behaves as a skin tumor suppressor
- Lubov Turovsky
- , Ghazal Kheshaiboun
- & Emily Avitan-Hersh
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Article
| Open AccessModulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress
- Silvia Cardarelli
- , Martina Biglietto
- & Manuela Pellegrini
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Article
| Open AccessAlternative Wnt-signaling axis leads to a break of oncogene-induced senescence
- Viola Kluge
- , Melanie Kappelmann-Fenzl
- & Anja-Katrin Bosserhoff
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Article
| Open AccessCHOP-mediated Gasdermin E expression promotes pyroptosis, inflammation, and mitochondrial damage in renal ischemia-reperfusion injury
- Nannan Ma
- , Hao Lu
- & Tao Zhang
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Article
| Open AccessLAPTM4B-mediated hepatocellular carcinoma stem cell proliferation and MDSC migration: implications for HCC progression and sensitivity to PD-L1 monoclonal antibody therapy
- Haojun Wang
- , Quanwei Zhou
- & Wei Wang
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Article
| Open AccessAdvanced oxidation protein products attenuate the autophagy-lysosome pathway in ovarian granulosa cells by modulating the ROS-dependent mTOR-TFEB pathway
- Xing-Yu Zhou
- , Yun-Hui Lai
- & Shi-Ling Chen
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Review Article
| Open AccessEndoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury
- Yayi Yang
- , Dengfeng Lu
- & Zhong Wang
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Article
| Open AccessHRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion
- Xuzi Zhao
- , Deshun Liu
- & Xiaofeng Tian
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Article
| Open AccessLeukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia
- Gioia Boncompagni
- , Vanessa Tatangelo
- & Cosima T. Baldari
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| Open AccessInnate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors
- Layla Shojaie
- , Jacob M. Bogdanov
- & Lily Dara
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Article
| Open AccessSALL4 promotes cancer stem-like cell phenotype and radioresistance in oral squamous cell carcinomas via methyltransferase-like 3-mediated m6A modification
- Junhong Huang
- , Huan Li
- & Jianhua Wei
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Article
| Open AccessPhosphorylation-dependent deubiquitinase OTUD3 regulates YY1 stability and promotes colorectal cancer progression
- Liang Wu
- , Zili Zhou
- & Zhengyi Liu
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Article
| Open AccessSingle-cell RNA sequencing of cervical exfoliated cells reveals potential biomarkers and cellular pathogenesis in cervical carcinogenesis
- Bo Sheng
- , Shuya Pan
- & Xueqiong Zhu
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Article
| Open AccessHistone demethylase KDM7A regulates bone homeostasis through balancing osteoblast and osteoclast differentiation
- Liying Shan
- , Xiaoli Yang
- & Baoli Wang
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Article
| Open AccessPRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling
- Tao Yang
- , Yongnan Chi
- & Denglong Wu
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Review Article
| Open AccessEnhancing osteoporosis treatment with engineered mesenchymal stem cell-derived extracellular vesicles: mechanisms and advances
- Yiman Chen
- , Yuling Huang
- & Lina Yang
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Article
| Open AccessSaracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL
- Jingyi Li
- , Xingfeng Liu
- & Lisheng Li
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Article
| Open AccessGITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice
- Li Li
- , Yu He
- & Ping Wang
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Article
| Open AccessTargeting AXL induces tumor-intrinsic immunogenic response in tyrosine kinase inhibitor-resistant liver cancer
- Yunong Xie
- , Haofeng Wu
- & Man Tong
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Article
| Open AccessACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota
- Tanja Eberhart
- , Federico Uchenna Stanley
- & Simone Cardaci
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Review Article
| Open AccessRoles of exosomes in immunotherapy for solid cancers
- Cong Lyu
- , Haifeng Sun
- & Qiming Wang
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Article
| Open AccessExosome-derived tRNA fragments tRF-GluCTC-0005 promotes pancreatic cancer liver metastasis by activating hepatic stellate cells
- Wei Chen
- , Wang Peng
- & Bin Cheng
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Article
| Open AccessNPAS2 dampens chemo-sensitivity of lung adenocarcinoma cells by enhancing DNA damage repair
- Youyu Zhang
- , Yuqiao Chen
- & Wei Zhuang
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Article
| Open AccessNecroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo
- Stefanie M. Bader
- , James P. Cooney
- & Marcel Doerflinger
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Article
| Open AccessTRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis
- Zehua Zhang
- , Xiaohan Yan
- & Meidong Xu
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Review Article
| Open AccessThe regulations of telomerase reverse transcriptase (TERT) in cancer
- Mingdi Liu
- , Yuning Zhang
- & Zhi-Xiang Xu
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Article
| Open AccessEpigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state
- Bo He
- , Lauren Stoffel
- & Jiangbin Ye
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Article
| Open AccessHECTD3 inhibits NLRP3 inflammasome assembly and activation by blocking NLRP3-NEK7 interaction
- Zhuo Cheng
- , Maobo Huang
- & Ceshi Chen
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Article
| Open AccessRBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis
- Erik J. Quiroz
- , Seongjae Kim
- & Amy L. Ryan
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Article
| Open AccessDNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1
- Siyu Chen
- , Wenxiang Zhang
- & Chang Liu
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Article
| Open AccessCOX6C expression driven by copy amplification of 8q22.2 regulates cell proliferation via mediation of mitosis by ROS-AMPK signaling in lung adenocarcinoma
- Shuanghui Liu
- , Fanggui Shao
- & Zhixiong Dong
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Review Article
| Open AccessThe multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications
- Faiz Ali Khan
- , Na Fang
- & Shaoping Ji
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Article
| Open AccessThe P286R mutation of DNA polymerase ε activates cancer-cell-intrinsic immunity and suppresses endometrial tumorigenesis via the cGAS-STING pathway
- Ming Tang
- , Shasha Yin
- & Guofang Chen
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Article
| Open AccessNon-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21
- Yue Sui
- , Qingqing Liu
- & Jianping Chen
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Article
| Open AccessGlucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain
- Qing Yu
- , Fang Du
- & Clarissa L. Waites
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Article
| Open AccessDietary long-chain fatty acids promote colitis by regulating palmitoylation of STAT3 through CD36-mediated endocytosis
- Yuping Wei
- , Jinting Li
- & Weiguo Dong
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Article
| Open AccessDDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis
- Haijiao Jin
- , Yuanting Yang
- & Qisheng Lin
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Article
| Open AccessFKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2α blockade by facilitating LDHA phosphorylation
- Ren Liu
- , Zhihao Zou
- & Weide Zhong
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Article
| Open AccessBACH2-mediated CD28 and CD40LG axes contribute to pathogenesis and progression of T-cell lymphoblastic leukemia
- Min Feng
- , Bailing Zhang
- & Han Zhang
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Article
| Open AccessTargeting POLRMT by a first-in-class inhibitor IMT1 inhibits osteosarcoma cell growth in vitro and in vivo
- Yang Kong
- , Xiangrong Li
- & Jin Dai
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Review Article
| Open AccessChimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
- Beibei Zhang
- , Mengzhe Yang
- & Tao Ren
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Article
| Open AccessUSP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons
- Justyna Okarmus
- , Jette Bach Agergaard
- & Morten Meyer
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Article
| Open AccessZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function
- Yue Zhu
- , Qinqin Wang
- & Gaoxiang Ge