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| Open AccessPRL-mediated STAT5B/ARRB2 pathway promotes the progression of prostate cancer through the activation of MAPK signaling
- Tao Yang
- , Yongnan Chi
- & Denglong Wu
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Review Article
| Open AccessEnhancing osteoporosis treatment with engineered mesenchymal stem cell-derived extracellular vesicles: mechanisms and advances
- Yiman Chen
- , Yuling Huang
- & Lina Yang
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Article
| Open AccessSaracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL
- Jingyi Li
- , Xingfeng Liu
- & Lisheng Li
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Article
| Open AccessGITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice
- Li Li
- , Yu He
- & Ping Wang
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Article
| Open AccessTargeting AXL induces tumor-intrinsic immunogenic response in tyrosine kinase inhibitor-resistant liver cancer
- Yunong Xie
- , Haofeng Wu
- & Man Tong
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Article
| Open AccessACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota
- Tanja Eberhart
- , Federico Uchenna Stanley
- & Simone Cardaci
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Review Article
| Open AccessRoles of exosomes in immunotherapy for solid cancers
- Cong Lyu
- , Haifeng Sun
- & Qiming Wang
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Article
| Open AccessExosome-derived tRNA fragments tRF-GluCTC-0005 promotes pancreatic cancer liver metastasis by activating hepatic stellate cells
- Wei Chen
- , Wang Peng
- & Bin Cheng
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Article
| Open AccessNPAS2 dampens chemo-sensitivity of lung adenocarcinoma cells by enhancing DNA damage repair
- Youyu Zhang
- , Yuqiao Chen
- & Wei Zhuang
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Article
| Open AccessNecroptosis does not drive disease pathogenesis in a mouse infective model of SARS-CoV-2 in vivo
- Stefanie M. Bader
- , James P. Cooney
- & Marcel Doerflinger
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Article
| Open AccessTRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis
- Zehua Zhang
- , Xiaohan Yan
- & Meidong Xu
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Review Article
| Open AccessThe regulations of telomerase reverse transcriptase (TERT) in cancer
- Mingdi Liu
- , Yuning Zhang
- & Zhi-Xiang Xu
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Article
| Open AccessEpigenetic priming targets tumor heterogeneity to shift transcriptomic phenotype of pancreatic ductal adenocarcinoma towards a Vitamin D susceptible state
- Bo He
- , Lauren Stoffel
- & Jiangbin Ye
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Article
| Open AccessHECTD3 inhibits NLRP3 inflammasome assembly and activation by blocking NLRP3-NEK7 interaction
- Zhuo Cheng
- , Maobo Huang
- & Ceshi Chen
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Article
| Open AccessRBL2 represses the transcriptional activity of Multicilin to inhibit multiciliogenesis
- Erik J. Quiroz
- , Seongjae Kim
- & Amy L. Ryan
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Article
| Open AccessDNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1
- Siyu Chen
- , Wenxiang Zhang
- & Chang Liu
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Article
| Open AccessCOX6C expression driven by copy amplification of 8q22.2 regulates cell proliferation via mediation of mitosis by ROS-AMPK signaling in lung adenocarcinoma
- Shuanghui Liu
- , Fanggui Shao
- & Zhixiong Dong
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Review Article
| Open AccessThe multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications
- Faiz Ali Khan
- , Na Fang
- & Shaoping Ji
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Article
| Open AccessThe P286R mutation of DNA polymerase ε activates cancer-cell-intrinsic immunity and suppresses endometrial tumorigenesis via the cGAS-STING pathway
- Ming Tang
- , Shasha Yin
- & Guofang Chen
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Article
| Open AccessNon-alcoholic fatty liver disease promotes breast cancer progression through upregulated hepatic fibroblast growth factor 21
- Yue Sui
- , Qingqing Liu
- & Jianping Chen
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Article
| Open AccessGlucocorticoid stress hormones stimulate vesicle-free Tau secretion and spreading in the brain
- Qing Yu
- , Fang Du
- & Clarissa L. Waites
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Article
| Open AccessDietary long-chain fatty acids promote colitis by regulating palmitoylation of STAT3 through CD36-mediated endocytosis
- Yuping Wei
- , Jinting Li
- & Weiguo Dong
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Article
| Open AccessDDRGK1-mediated ER-phagy attenuates acute kidney injury through ER-stress and apoptosis
- Haijiao Jin
- , Yuanting Yang
- & Qisheng Lin
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Article
| Open AccessFKBP10 promotes clear cell renal cell carcinoma progression and regulates sensitivity to the HIF2α blockade by facilitating LDHA phosphorylation
- Ren Liu
- , Zhihao Zou
- & Weide Zhong
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Article
| Open AccessBACH2-mediated CD28 and CD40LG axes contribute to pathogenesis and progression of T-cell lymphoblastic leukemia
- Min Feng
- , Bailing Zhang
- & Han Zhang
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Article
| Open AccessTargeting POLRMT by a first-in-class inhibitor IMT1 inhibits osteosarcoma cell growth in vitro and in vivo
- Yang Kong
- , Xiangrong Li
- & Jin Dai
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Review Article
| Open AccessChimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
- Beibei Zhang
- , Mengzhe Yang
- & Tao Ren
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Article
| Open AccessUSP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons
- Justyna Okarmus
- , Jette Bach Agergaard
- & Morten Meyer
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Article
| Open AccessZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function
- Yue Zhu
- , Qinqin Wang
- & Gaoxiang Ge
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Article
| Open AccessUSP43 stabilizes c-Myc to promote glycolysis and metastasis in bladder cancer
- Mingxing Li
- , Jingtian Yu
- & Xinghuan Wang
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Review Article
| Open AccessAmino acid metabolism in tumor biology and therapy
- Jie Chen
- , Likun Cui
- & Sheng Xu
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Article
| Open AccessIFITM3 promotes glioblastoma stem cell-mediated angiogenesis via regulating JAK/STAT3/bFGF signaling pathway
- Zhangsheng Xiong
- , Xiangdong Xu
- & Yang Liu
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Article
| Open AccessActivated hepatic stellate cell-derived Bmp-1 induces liver fibrosis via mediating hepatocyte epithelial-mesenchymal transition
- Sizhe Wan
- , Xianzhi Liu
- & Bin Wu
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Article
| Open AccessCortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity
- Yiwei Feng
- , Lishan Lin
- & Zhong Pei
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Article
| Open AccessEpigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses
- Shuang Ding
- , Haibin Liu
- & Wuxiang Guan
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Article
| Open AccessE3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis
- Yingjie Huang
- , Tao Chen
- & Yong Li
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Article
| Open AccessThe heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
- Yangyang Feng
- , Ming Zhao
- & Chu-Xia Deng
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Article
| Open AccessPalmitate induces integrated stress response and lipoapoptosis in trophoblasts
- Prakash Kumar Sahoo
- , Chandan Krishnamoorthy
- & Sathish Kumar Natarajan
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Article
| Open AccessFBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression
- Jing Ji
- , Aixin Jing
- & Bin Liu
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Article
| Open AccessAmyloid aggregates induced by the p53-R280T mutation lead to loss of p53 function in nasopharyngeal carcinoma
- Jingzhi Li
- , Ming Guo
- & Yongheng Chen
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Article
| Open AccessAntitumour effect of the mitochondrial complex III inhibitor Atovaquone in combination with anti-PD-L1 therapy in mouse cancer models
- Gonzalo Rodriguez-Berriguete
- , Rathi Puliyadi
- & Geoff S. Higgins
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Article
| Open AccessDeath receptor 5 is required for intestinal stem cell activity during intestinal epithelial renewal at homoeostasis
- Jianbo Liu
- , Kaixuan Liu
- & Bing Xue
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Article
| Open AccessEvaluation of apoptosis stimulating protein of TP53-1 (ASPP1/PPP1R13B) to predict therapy resistance and overall survival in acute myeloid leukemia (AML)
- Marcus M. Schittenhelm
- , Max Kaiser
- & Kerstin M. Kampa-Schittenhelm
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Article
| Open AccessCRABP2 affects chemotherapy resistance of ovarian cancer by regulating the expression of HIF1α
- Xin Fu
- , Qian Zhang
- & Qiuping Dong
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Article
| Open AccessCharacterizing influence of rCHOP treatment on diffuse large B-cell lymphoma microenvironment through in vitro microfluidic spheroid model
- Matthew R. Sullivan
- , Rachel P. White
- & Tania Konry
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Article
| Open AccessVaricella zoster virus glycoprotein E facilitates PINK1/Parkin-mediated mitophagy to evade STING and MAVS-mediated antiviral innate immunity
- Soo-Jin Oh
- , Je-Wook Yu
- & Ok Sarah Shin
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Article
| Open AccessNovel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer
- Qingyun Zhu
- , Qiuzi Dai
- & Yuyang Jiang
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Article
| Open AccessTargeting NEDD8 suppresses surgical stress-facilitated metastasis of colon cancer via restraining regulatory T cells
- Yi Jiang
- , Shenjia Gao
- & Wankun Chen
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Article
| Open AccessNuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ
- Yanxiong Yu
- , Mohammad S. Farooq
- & Elke Burgermeister