Endocrine system

The endocrine system refers to the cells, glands and organs that secrete hormones directly into the blood in order to control physiological and behavioural activities. The effects of the endocrine system are slow to initiate and can have long-term effects.

Latest Research and Reviews

  • Reviews |

    The re-emerging mosquito-transmitted flavivirus Zika seems to be sexually transmitted and can persist in the male genital tract, presenting as genitourinary symptoms such as haematospermia, prostatitis, painful ejaculation, penile discharge, and oligospermia. In this Review, the authors explain the mechanisms that underlie persistent Zika infections in men and describe why these are crucial to developing guidelines, effective vaccines, and therapies.

    • Fábio A. Kurscheidt
    • , Cristiane S. S. Mesquita
    • , Gabrielle M. Z. F. Damke
    • , Edilson Damke
    • , Analine R. B. de A. Carvalho
    • , Tamy T. Suehiro
    • , Jorge J. V. Teixeira
    • , Vânia R. S. da Silva
    • , Raquel P. Souza
    •  & Marcia E. L. Consolaro
  • Reviews |

    Loss or dysfunction of β-cells is a characteristic of insulin-dependent diabetes mellitus. Regeneration of β-cells might stop or reverse the progression of the disease. This Review discusses the different modelling systems and technologies currently used to study β-cell biology in health and disease.

    • Mostafa Bakhti
    • , Anika Böttcher
    •  & Heiko Lickert
  • Research | | open

    Thyroid dysfunction is a common public health problem and associated with cardiovascular co-morbidities. Here, the authors carry out genome-wide meta-analysis for thyroid hormone (TH) levels, hyper- and hypothyroidism and identify SLC17A4 as a TH transporter and AADAT as a TH metabolizing enzyme.

    • Alexander Teumer
    • , Layal Chaker
    • , Stefan Groeneweg
    • , Yong Li
    • , Celia Di Munno
    • , Caterina Barbieri
    • , Ulla T. Schultheiss
    • , Michela Traglia
    • , Tarunveer S. Ahluwalia
    • , Masato Akiyama
    • , Emil Vincent R. Appel
    • , Dan E. Arking
    • , Alice Arnold
    • , Arne Astrup
    • , Marian Beekman
    • , John P. Beilby
    • , Sofie Bekaert
    • , Eric Boerwinkle
    • , Suzanne J. Brown
    • , Marc De Buyzere
    • , Purdey J. Campbell
    • , Graziano Ceresini
    • , Charlotte Cerqueira
    • , Francesco Cucca
    • , Ian J. Deary
    • , Joris Deelen
    • , Kai-Uwe Eckardt
    • , Arif B. Ekici
    • , Johan G. Eriksson
    • , Luigi Ferrrucci
    • , Tom Fiers
    • , Edoardo Fiorillo
    • , Ian Ford
    • , Caroline S. Fox
    • , Christian Fuchsberger
    • , Tessel E. Galesloot
    • , Christian Gieger
    • , Martin Gögele
    • , Alessandro De Grandi
    • , Niels Grarup
    • , Karin Halina Greiser
    • , Kadri Haljas
    • , Torben Hansen
    • , Sarah E. Harris
    • , Diana van Heemst
    • , Martin den Heijer
    • , Andrew A. Hicks
    • , Wouter den Hollander
    • , Georg Homuth
    • , Jennie Hui
    • , M. Arfan Ikram
    • , Till Ittermann
    • , Richard A. Jensen
    • , Jiaojiao Jing
    • , J. Wouter Jukema
    • , Eero Kajantie
    • , Yoichiro Kamatani
    • , Elisa Kasbohm
    • , Jean-Marc Kaufman
    • , Lambertus A. Kiemeney
    • , Margreet Kloppenburg
    • , Florian Kronenberg
    • , Michiaki Kubo
    • , Jari Lahti
    • , Bruno Lapauw
    • , Shuo Li
    • , David C. M. Liewald
    • , Behrooz Z. Alizadeh
    • , H. Marike Boezen
    • , Lude Franke
    • , Pim van der Harst
    • , Gerjan Navis
    • , Marianne Rots
    • , Harold Snieder
    • , Morris A. Swertz
    • , Cisca Wijmenga
    • , Ee Mun Lim
    • , Allan Linneberg
    • , Michela Marina
    • , Deborah Mascalzoni
    • , Koichi Matsuda
    • , Daniel Medenwald
    • , Christa Meisinger
    • , Ingrid Meulenbelt
    • , Tim De Meyer
    • , Henriette E. Meyer zu Schwabedissen
    • , Rafael Mikolajczyk
    • , Matthijs Moed
    • , Romana T. Netea-Maier
    • , Ilja M. Nolte
    • , Yukinori Okada
    • , Mauro Pala
    • , Cristian Pattaro
    • , Oluf Pedersen
    • , Astrid Petersmann
    • , Eleonora Porcu
    • , Iris Postmus
    • , Peter P. Pramstaller
    • , Bruce M. Psaty
    • , Yolande F. M. Ramos
    • , Rajesh Rawal
    • , Paul Redmond
    • , J. Brent Richards
    • , Ernst R. Rietzschel
    • , Fernando Rivadeneira
    • , Greet Roef
    • , Jerome I. Rotter
    • , Cinzia F. Sala
    • , David Schlessinger
    • , Elizabeth Selvin
    • , P. Eline Slagboom
    • , Nicole Soranzo
    • , Thorkild I. A. Sørensen
    • , Timothy D. Spector
    • , John M. Starr
    • , David J. Stott
    • , Youri Taes
    • , Daniel Taliun
    • , Toshiko Tanaka
    • , Betina Thuesen
    • , Daniel Tiller
    • , Daniela Toniolo
    • , Andre G. Uitterlinden
    • , W. Edward Visser
    • , John P. Walsh
    • , Scott G. Wilson
    • , Bruce H. R. Wolffenbuttel
    • , Qiong Yang
    • , Hou-Feng Zheng
    • , Anne Cappola
    • , Robin P. Peeters
    • , Silvia Naitza
    • , Henry Völzke
    • , Serena Sanna
    • , Anna Köttgen
    • , Theo J. Visser
    •  & Marco Medici
  • Reviews |

    The signalling events leading to insulin release from β-cells are tightly controlled and new techniques are needed to understand the complicated interactions. This Review discusses new optical tools available to further our understanding of β-cell function and insulin release.

    • James A. Frank
    • , Johannes Broichhagen
    • , Dmytro A. Yushchenko
    • , Dirk Trauner
    • , Carsten Schultz
    •  & David J. Hodson
  • Reviews |

    Over the past 10 years, evidence has accumulated to suggest that α-cells are involved in the development of diabetes mellitus. This Review outlines our current understanding of α-cells and discusses how they could be targeted in the treatment of diabetes mellitus.

    • Jesper Gromada
    • , Pauline Chabosseau
    •  & Guy A. Rutter

News and Comment