Featured
-
-
Article
| Open AccessClassical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation
- Feier Zeng
- , Abbie Wade
- & Aymen I. Idris
-
Article
| Open AccessA high-throughput gut-on-chip platform to study the epithelial responses to enterotoxins
- Moran Morelli
- , Marta Cabezuelo Rodríguez
- & Karla Queiroz
-
Article
| Open AccessPharmacological evaluation and phytochemical profiling of butanol extract of L. edodes with in- silico virtual screening
- Umer Ejaz
- , Muhammad Afzal
- & Abdullah F. Alasmari
-
Article
| Open AccessBioinformatics analysis and experimental validation revealed that Paeoniflorigenone effectively mitigates cerebral ischemic stroke by suppressing oxidative stress and inflammation
- Zhiyan Wu
- & Xingrong Tang
-
Article
| Open AccessEvaluation of the mosquitocidal efficacy of fluralaner, a potential candidate for drug based vector control
- Harish Kumar Shah
- , Vaishnavi Srinivasan
- & Vijesh Sreedhar Kuttiatt
-
Article
| Open AccessSynthesis, anticancer activity, and molecular docking of half-sandwich iron(II) cyclopentadienyl complexes with maleimide and phosphine or phosphite ligands
- Sujoy Das
- , Marcelina Strachanowska
- & Bogna Rudolf
-
Article
| Open AccessThe deleterious effects of sofosbuvir and ribavirin (antiviral drugs against hepatitis C virus) on different body systems in male albino rats regarding reproductive, hematological, biochemical, hepatic, and renal profiles and histopathological changes
- Rana A. Ali
- , Eatemad A. Awadalla
- & Rehab H. Abdel-Aziz
-
Article
| Open AccessEmerging roles of SIRT1 activator, SRT2104, in disease treatment
- Ning Chang
- , Junyang Li
- & Yajun Wang
-
Article
| Open AccessSynthesis and evaluation of coumarin derivatives on antioxidative, tyrosinase inhibitory activities, melanogenesis, and in silico investigations
- Kasemsiri Chandarajoti
- , Jiraporn Kara
- & Luelak Lomlim
-
Article
| Open AccessStructural basis for the recognition of human hemoglobin by the heme-acquisition protein Shr from Streptococcus pyogenes
- Akinobu Senoo
- , Masato Hoshino
- & Kouhei Tsumoto
-
Article
| Open AccessTranscriptomic screening of novel targets of sericin in human hepatocellular carcinoma cells
- Jiraporn Jantaravinid
- , Napatara Tirawanchai
- & Pornanong Aramwit
-
Article
| Open AccessInvestigating the mechanisms underlying resistance to chemoterapy and to CRISPR-Cas9 in cancer cell lines
- Francesca Tomasi
- , Matteo Pozzi
- & Mario Lauria
-
Article
| Open AccessComparable safety and non-inferior immunogenicity of the SARS-CoV-2 mRNA vaccine candidate PTX-COVID19-B and BNT162b2 in a phase 2 randomized, observer-blinded study
- Lawrence Reiter
- , Johann Greffrath
- & Aleksandra Pastrak
-
Article
| Open AccessAiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3
- Sumin Lee
- , Qianying Ye
- & Yong Hwan Park
-
Article
| Open AccessA real-world analysis of FDA Adverse Event Reporting System (FAERS) events for liposomal and conventional doxorubicins
- Huiling Su
- , Jing Jia
- & Zhengjun Li
-
Article
| Open AccessA novel T cell-redirecting anti-GPRC5D × CD3 bispecific antibody with potent antitumor activity in multiple myeloma preclinical models
- Urara Tomita
- , Yoko Ishimoto
- & Toshinori Agatsuma
-
Article
| Open AccessEnhancing colistin efficacy against Salmonella infections with a quinazoline-based dual therapeutic strategy
- Carlos A. Lobertti
- , Fernán O. Gizzi
- & Eleonora García Véscovi
-
Article
| Open AccessConjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation
- Mei Ying Ng
- , Zhi Jian Song
- & Thilo Hagen
-
Article
| Open AccessCytotoxic naphtho- and benzofurans from an endophytic fungus Epicoccum nigrum Ann-B-2 associated with Annona squamosa fruits
- Mohamed S. Elnaggar
- , Shaimaa Fayez
- & Sherif S. Ebada
-
Article
| Open AccessCytotoxic and antiviral activities of Jatropha variegata and Jatropha spinosa in relation to their metabolite profile
- Khawlah Shari
- , Osama G. Mohamed
- & Rania A. El Gedaily
-
Article
| Open AccessMachine learning driven web-based app platform for the discovery of monoamine oxidase B inhibitors
- Sunil Kumar
- , Ratul Bhowmik
- & Bijo Mathew
-
Article
| Open AccessApomorphine is a potent inhibitor of ferroptosis independent of dopaminergic receptors
- Akihiko Miyauchi
- , Chika Watanabe
- & Hitoshi Osaka
-
Article
| Open AccessMortality after major bleeding in Asian atrial fibrillation patients receiving different direct oral anticoagulants: a nationwide, propensity score study
- Jiun-Hao Yu
- , Pei-Ru Li
- & Lai-Chu See
-
Article
| Open AccessSpray-dried pH-sensitive chitosan microparticles loaded with Mycobacterium bovis BCG intended for supporting treatment of Helicobacter pylori infection
- Weronika Gonciarz
- , Marek Brzeziński
- & Magdalena Chmiela
-
Article
| Open AccessStudy of the mechanism by gentiopicroside protects against skin fibroblast glycation damage via the RAGE pathway
- Chunyu Chen
- , Xiaoxing Liu
- & Fan Yi
-
Article
| Open AccessRestoring functional TDP-43 oligomers in ALS and laminopathic cellular models through baicalein-induced reconfiguration of TDP-43 aggregates
- Hsiang-Yu Chang
- & I-Fan Wang
-
Article
| Open AccessStructure–activity characteristics of phenylalanine analogs selectively transported by L-type amino acid transporter 1 (LAT1)
- Sihui Chen
- , Chunhuan Jin
- & Yoshikatsu Kanai
-
Article
| Open AccessNovel antimicrobial peptides against Cutibacterium acnes designed by deep learning
- Qichang Dong
- , Shaohua Wang
- & Lun Yu
-
Article
| Open AccessKinetic characterization of human mRNA guanine-N7 methyltransferase
- Sumera Perveen
- , Aliakbar Khalili Yazdi
- & Masoud Vedadi
-
Article
| Open AccessA bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation and PDE activity
- Dareen Mikheil
- , Matthew A. Larsen
- & Said A. Goueli
-
Article
| Open AccessAntioxidant, antimicrobial and healing properties of an extract from coffee pulp for the development of a phytocosmetic
- Érica Mendes dos Santos
- , Lucas Malvezzi de Macedo
- & Priscila Gava Mazzola
-
Article
| Open AccessPredicting the formation of NADES using a transformer-based model
- Lucas B. Ayres
- , Federico J. V. Gomez
- & Carlos D. Garcia
-
Article
| Open AccessRepeated microdoses of LSD do not alter anxiety or boldness in zebrafish
- Ethan V. Hagen
- , Melike Schalomon
- & Trevor J. Hamilton
-
Article
| Open AccessNetwork analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of COVID, Alzheimer’s, and diabetes
- Dicson Sheeja Malar
- , Kanika Verma
- & James Michael Brimson
-
Article
| Open AccessHepa-ToxMOA: a pathway-screening method for evaluating cellular stress and hepatic metabolic-dependent toxicity of natural products
- Se-Myo Park
- , Mi-Sun Choi
- & Jung-Hwa Oh
-
Article
| Open AccessModeling dry eye with an air–liquid interface in corneal epithelium-on-a-chip
- Rodi Kado Abdalkader
- , Romanas Chaleckis
- & Ken-ichiro Kamei
-
Article
| Open AccessMultimodal CNN-DDI: using multimodal CNN for drug to drug interaction associated events
- Muhammad Asfand-e-yar
- , Qadeer Hashir
- & Waqar Khalil
-
Article
| Open AccessCombined substituent number utilized machine learning for the development of antimicrobial agent
- Keitaro Yamauchi
- , Hirotaka Nakatsuji
- & Hitoshi Kasai
-
Article
| Open AccessTargeting host-virus interactions: in silico analysis of the binding of human milk oligosaccharides to viral proteins involved in respiratory infections
- Anees Ahmed Mahaboob Ali
- , Adarsh Vishal
- & Everette Jacob Remington Nelson
-
Article
| Open AccessProcess optimization for green synthesis of silver nanoparticles using Rubus discolor leaves extract and its biological activities against multi-drug resistant bacteria and cancer cells
- Saeed Ghasemi
- , Sara Dabirian
- & Fatemeh Yousefbeyk
-
Article
| Open AccessTargeting autophagy as a therapeutic strategy in pediatric acute lymphoblastic leukemia
- Henri Colyn Bwanika
- , Isabelle Rose Leo
- & Katja Pokrovskaja Tamm
-
Article
| Open AccessToxoflavin analog D43 exerts antiproliferative effects on breast cancer by inducing ROS-mediated apoptosis and DNA damage
- Tingyue Wu
- , Wenjing Liu
- & Ceshi Chen
-
Article
| Open AccessCarbon supported ternary layered double hydroxide nanocomposite for Fluoxetine removal and subsequent utilization of spent adsorbent as antidepressant
- Samar M. Mahgoub
- , Doaa Essam
- & Rehab Mahmoud
-
Article
| Open AccessProlyl hydroxylase domain inhibitor is an effective pre-hospital pharmaceutical intervention for trauma and hemorrhagic shock
- Xiaowu Wu
- , Andrew P. Cap
- & Michael A. Meledeo
-
Article
| Open AccessKaempferol mitigates reproductive dysfunctions induced by Naja nigricollis venom through antioxidant system and anti-inflammatory response in male rats
- Akindele Oluwatosin Adeyi
- , Babafemi Siji Ajisebiola
- & Olukunle Silas Fagbenro
-
Article
| Open AccessHIF-2α-dependent TGFBI promotes ovarian cancer chemoresistance by activating PI3K/Akt pathway to inhibit apoptosis and facilitate DNA repair process
- Sijia Ma
- , Jia Wang
- & Le Zhao
-
Article
| Open AccessHigh-throughput screening assay for PARP-HPF1 interaction inhibitors to affect DNA damage repair
- Saurabh S. Dhakar
- , Albert Galera-Prat
- & Lari Lehtiö
-
Article
| Open AccessRipa-56 protects retinal ganglion cells in glutamate-induced retinal excitotoxic model of glaucoma
- Lemeng Feng
- , Shirui Dai
- & Weitao Song
-
Article
| Open Access1H NMR metabolomics insights into comparative diabesity in male and female zebrafish and the antidiabetic activity of DL-limonene
- Khaled Benchoula
- , Christopher J. Serpell
- & Wong Eng Hwa