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| Open AccessPreclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors
- Christoph Grohmann
- , Francesca Walker
- & Guillaume Lessene
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| Open AccessCiclopirox and bortezomib synergistically inhibits glioblastoma multiforme growth via simultaneously enhancing JNK/p38 MAPK and NF-κB signaling
- Zhipeng Su
- , Shengnan Han
- & Bin Lu
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| Open AccessInduction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential
- Shuai Huang
- , Bihui Cao
- & Baoxia Liang
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| Open AccessPolycysteine as a new type of radio-protector ameliorated tissue injury through inhibiting ferroptosis in mice
- Junling Zhang
- , Kui Li
- & Hongqi Tian
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| Open AccessThe armed oncolytic adenovirus ZD55-IL-24 eradicates melanoma by turning the tumor cells from the self-state into the nonself-state besides direct killing
- Hai-Jun Hu
- , Xiu Liang
- & Xin-Yuan Liu
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| Open AccessA small natural molecule CADPE kills residual colorectal cancer cells by inhibiting key transcription factors and translation initiation factors
- Guo-Wan Zheng
- , Ming-Min Tang
- & Xiao-Yuan Lian
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| Open AccessFisetin inhibits proliferation of pancreatic adenocarcinoma by inducing DNA damage via RFXAP/KDM4A-dependent histone H3K36 demethylation
- Guoping Ding
- , Xiaodong Xu
- & Liping Cao
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| Open AccessClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma
- Zhuoyu Gu
- , Liping Wang
- & Yixin Li
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| Open AccessCB13, a novel PPARγ ligand, overcomes radio-resistance via ROS generation and ER stress in human non-small cell lung cancer
- Tae Woo Kim
- , Da-Won Hong
- & Sung Hee Hong
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Review Article
| Open AccessMitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
- Kazem Nouri
- , Yue Feng
- & Aaron D. Schimmer
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| Open AccessPreclinical evaluation of a regimen combining chidamide and ABT-199 in acute myeloid leukemia
- Kai Chen
- , Qianying Yang
- & Bing Xu
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| Open AccessReactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer
- Liguo Yang
- , Xiaoshu Zhou
- & Yi Ding
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| Open AccessThe triterpenoid sapogenin (2α-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling
- Zhifu Xie
- , Haowen Jiang
- & Jingya Li
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| Open AccessThe antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis
- Laia París-Coderch
- , Aroa Soriano
- & Miguel F. Segura
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| Open AccessDefining the susceptibility of colorectal cancers to BH3-mimetic compounds
- Ming-Jie Luo
- , Michelle Palmieri
- & Jia-nan Gong
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| Open AccessSH003 activates autophagic cell death by activating ATF4 and inhibiting G9a under hypoxia in gastric cancer cells
- Tae Woo Kim
- , Chunhoo Cheon
- & Seong-Gyu Ko
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| Open AccessDual targeting of NUAK1 and ULK1 using the multitargeted inhibitor MRT68921 exerts potent antitumor activities
- Yiran Chen
- , Xiaoling Xie
- & Yuhua Li
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| Open AccessXJB-5-131 inhibited ferroptosis in tubular epithelial cells after ischemia−reperfusion injury
- Zhi Zhao
- , Jianliang Wu
- & Gang Xu
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| Open AccessHomoharringtonine suppresses tumor proliferation and migration by regulating EphB4-mediated β-catenin loss in hepatocellular carcinoma
- Man Zhu
- , Zhengyan Gong
- & Yanmin Zhang
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| Open AccessNovel ginsenoside derivative 20(S)-Rh2E2 suppresses tumor growth and metastasis in vivo and in vitro via intervention of cancer cell energy metabolism
- Qi Huang
- , Hui Zhang
- & Vincent Kam Wai Wong
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| Open AccessCombining triptolide with ABT-199 is effective against acute myeloid leukemia through reciprocal regulation of Bcl-2 family proteins and activation of the intrinsic apoptotic pathway
- Yuan-Fei Shi
- , Long Liu
- & Bing Xu
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| Open AccessItraconazole inhibits the Hedgehog signaling pathway thereby inducing autophagy-mediated apoptosis of colon cancer cells
- Huiming Deng
- , Ling Huang
- & Ronghua Xu
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| Open AccessSpermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis
- Zhong Chen
- , Chuang-Xin Lin
- & Yue Ding
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| Open AccessPD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer
- Wendan Yu
- , Yijun Hua
- & Wuguo Deng
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Article
| Open AccessEndogenously produced LG3/4/5-peptide protects testes against toxicant-induced injury
- Linxi Li
- , Baiping Mao
- & C. Yan Cheng
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Article
| Open AccessCharacterization of a new small-molecule inhibitor of HDAC6 in glioblastoma
- Jaione Auzmendi-Iriarte
- , Ander Saenz-Antoñanzas
- & Ander Matheu
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Article
| Open AccessCuprous oxide nanoparticles trigger reactive oxygen species-induced apoptosis through activation of erk-dependent autophagy in bladder cancer
- Qiao Xiong
- , Anwei Liu
- & Chuanliang Xu
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Article
| Open AccessMeasurement and models accounting for cell death capture hidden variation in compound response
- Song Yi Bae
- , Ning Guan
- & Aaron S. Meyer
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| Open AccessPan-cancer analysis reveals synergistic effects of CDK4/6i and PARPi combination treatment in RB-proficient and RB-deficient breast cancer cells
- Songyu Li
- , Yixiang Zhang
- & Qing-kai Yang
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Article
| Open AccessMetformin reduces HGF-induced resistance to alectinib via the inhibition of Gab1
- Hengyi Chen
- , Caiyu Lin
- & Yong He
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Review Article
| Open AccessErythropoietin and its derivatives: from tissue protection to immune regulation
- Bo Peng
- , Gangcheng Kong
- & Yingzi Ming
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Article
| Open AccessAnticancer activity of dietary xanthone α-mangostin against hepatocellular carcinoma by inhibition of STAT3 signaling via stabilization of SHP1
- Hai Zhang
- , Yu-ping Tan
- & Xiao-fei Shen
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Article
| Open AccessTheranostic combinatorial drug-loaded coated cubosomes for enhanced targeting and efficacy against cancer cells
- Leilei Zhang
- , Jinlong Li
- & Miao Tian
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Article
| Open AccessFGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival
- Kailiang Zhou
- , Huanwen Chen
- & Huazi Xu
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Article
| Open AccessRITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity
- Johannes Ristau
- , Vincent van Hoef
- & Ola Larsson
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Article
| Open AccessThe natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II
- Hye-Young Min
- , Hyun-Ji Jang
- & Ho-Young Lee
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| Open AccessCannabidiol directly targets mitochondria and disturbs calcium homeostasis in acute lymphoblastic leukemia
- Miguel Olivas-Aguirre
- , Liliana Torres-López
- & Oxana Dobrovinskaya
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| Open AccessKinase-independent inhibition of cyclophosphamide-induced pathways protects the ovarian reserve and prolongs fertility
- Giovanna Bellusci
- , Luca Mattiello
- & Stefania Gonfloni
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Article
| Open AccessDominant-negative ATF5 rapidly depletes survivin in tumor cells
- Xiaotian Sun
- , James M. Angelastro
- & Lloyd A. Greene
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| Open AccessSelective eradication of human non-small cell lung cancer cells using aptamer-decorated nanoparticles harboring a cytotoxic drug cargo
- Shira Engelberg
- , Einat Netzer
- & Yoav D. Livney
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Article
| Open AccessDynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma
- Binlong Zhong
- , Deyao Shi
- & Zengwu Shao
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Article
| Open AccessPaeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells
- Likun Gao
- , Zhi Wang
- & Li Hong
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| Open AccessAutophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response
- Wen-Yueh Hung
- , Jer-Hwa Chang
- & Ming-Hsien Chien
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| Open AccessDiscovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity
- Xin-yang Li
- , Ting-jian Zhang
- & Fan-hao Meng
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Article
| Open AccessCombined treatment with emodin and a telomerase inhibitor induces significant telomere damage/dysfunction and cell death
- Rui Liu
- , Jing Liu
- & Feng Wang
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Article
| Open AccessLZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells
- Yongjian Guo
- , Yue Zhao
- & Xiaotang Wang
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Article
| Open AccessSilver nanoparticles selectively induce human oncogenic γ-herpesvirus-related cancer cell death through reactivating viral lytic replication
- Chunlei Wan
- , Jiahui Tai
- & Qiliang Cai
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Article
| Open AccessBaicalein inhibits fibronectin-induced epithelial–mesenchymal transition by decreasing activation and upregulation of calpain-2
- Yan Chen
- , Lin Chen
- & Xiangchun Shen
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Article
| Open AccessBlockade of HMGB1 signaling pathway by ethyl pyruvate inhibits tumor growth in diffuse large B-cell lymphoma
- Tian Zhang
- , Xu-Wen Guan
- & Li Jia