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| Open AccessTargeting nerve growth factor-mediated osteosarcoma metastasis: mechanistic insights and therapeutic opportunities using larotrectinib
- Chun-Han Hou
- , Wei-Li Chen
- & Chih-Yang Lin
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Article
| Open AccessTherapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis)
- Zihuan Wang
- , Xu Zhang
- & Changjie Wu
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Article
| Open AccessTargeting ARNT attenuates chemoresistance through destabilizing p38α-MAPK signaling in glioblastoma
- Wahafu Alafate
- , Gen Lv
- & Peng Wang
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Article
| Open AccessIL-33/NF-κB/ST2L/Rab37 positive-feedback loop promotes M2 macrophage to limit chemotherapeutic efficacy in lung cancer
- You-En Yang
- , Meng-Hsuan Hu
- & Yi-Ching Wang
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| Open AccessTargeting the mitochondrial protein YME1L to inhibit osteosarcoma cell growth in vitro and in vivo
- Xu Sun
- , Ce Shi
- & Lei Yang
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Article
| Open AccessIron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis
- Qingyu Zhang
- , Caiyun Chen
- & Aizhen Fu
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Review Article
| Open AccessThe role of circular RNAs in regulating resistance to cancer immunotherapy: mechanisms and implications
- Yu Ma
- , Ting Wang
- & Fangyi Long
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Review Article
| Open AccessModulating extracellular matrix stiffness: a strategic approach to boost cancer immunotherapy
- Zizhao Mai
- , Yunfan Lin
- & Li Cui
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Article
| Open AccessA potential strategy for bladder cancer treatment: inhibiting autophagy to enhance antitumor effects of Nectin-4-MMAE
- Yichen Wang
- , Yanyang Nan
- & Xuyao Zhang
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Article
| Open AccessID1high/activin Ahigh glioblastoma cells contribute to resistance to anti-angiogenesis therapy through malformed vasculature
- Sang-Hun Choi
- , Junseok Jang
- & Hyunggee Kim
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Article
| Open AccessAnnexin A2 combined with TTK accelerates esophageal cancer progression via the Akt/mTOR signaling pathway
- Ruiqi Liu
- , Yanwei Lu
- & Haibo Zhang
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Article
| Open AccessTAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers
- Helene Damhofer
- , Tülin Tatar
- & Kristian Helin
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| Open AccessIdentification of a novel form of caspase-independent cell death triggered by BH3-mimetics in diffuse large B-cell lymphoma cell lines
- Nahide Yildirim
- , Lakshmi Sarojam
- & Meike Vogler
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Article
| Open AccessSTING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells
- Ling Wang
- , Zhaoduan Liang
- & Yirong Sun
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Article
| Open AccessPDZK1 suppresses TNBC development and sensitizes TNBC cells to erlotinib via the EGFR pathway
- Yuanzhen Ma
- , Zhiyu Fang
- & Junfang Zheng
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Article
| Open AccessCombination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer
- Rhynelle S. Dmello
- , Michelle Palmieri
- & Ashwini L. Chand
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Review Article
| Open AccessAdvances in Engineered Macrophages: A New Frontier in Cancer Immunotherapy
- Shuaixi Yang
- , Yuhang Wang
- & Junhong Hu
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Article
| Open AccessPQR309, a dual PI3K/mTOR inhibitor, synergizes with gemcitabine by impairing the GSK-3β and STAT3/HSP60 signaling pathways to treat nasopharyngeal carcinoma
- Jiaxin Cao
- , Kangmei Zeng
- & Hongyun Zhao
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Article
| Open AccessAURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis
- Bing Deng
- , Fang Liu
- & Quentin Liu
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Article
| Open AccessHMGA2 alleviates ferroptosis by promoting GPX4 expression in pancreatic cancer cells
- Ziyang Luo
- , Qingfang Zheng
- & Yang Xi
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Article
| Open AccessHistidine re-sensitizes pediatric acute lymphoblastic leukemia to 6-mercaptopurine through tetrahydrofolate consumption and SIRT5-mediated desuccinylation
- Na Dong
- , Hui-Xian Ma
- & Xiu-Li Ju
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Article
| Open AccessTAB182 regulates glycolytic metabolism by controlling LDHA transcription to impact tumor radiosensitivity
- Shi Chen
- , Da-Fei Xie
- & Ping-Kun Zhou
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Article
| Open AccessA first-in-class TIMM44 blocker inhibits bladder cancer cell growth
- Lifeng Zhang
- , Xiaokai Shi
- & Shenglin Gao
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Article
| Open AccessMCL1 inhibition targets Myeloid Derived Suppressors Cells, promotes antitumor immunity and enhances the efficacy of immune checkpoint blockade
- Nabanita Mukherjee
- , Elizabeth Katsnelson
- & Yiqun G. Shellman
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Article
| Open AccessSynergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer
- Hongfu Liu
- , Dongdong Zhou
- & Shuyong Zhang
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Article
| Open AccessCircNUP54 promotes hepatocellular carcinoma progression via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA
- Chenwei Tang
- , Hongkai Zhuang
- & Changzhen Shang
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Article
| Open AccessBCL-XL inhibitors enhance the apoptotic efficacy of BRAF inhibitors in BRAFV600E colorectal cancer
- Laura J. Jenkins
- , Ian Y. Luk
- & John M. Mariadason
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Article
| Open AccessKEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC
- Jinghan Li
- , Daiwang Shi
- & Hong-Xu Liu
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Article
| Open AccessConcurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRASG12D-mutant pancreatic ductal adenocarcinoma
- Yan Qin Tan
- , Bowen Sun
- & Vijay Pandey
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Article
| Open AccessPRMT1-mediated PGK1 arginine methylation promotes colorectal cancer glycolysis and tumorigenesis
- Hao Liu
- , Xintian Chen
- & Xiangyang Yu
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Article
| Open AccessModification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells
- Zhihui Dou
- , Huiwen Lei
- & Cuixia Di
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Article
| Open AccessTargeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence
- Maria Rita Fabbrizi
- , Catherine M. Nickson
- & Jason L. Parsons
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Article
| Open AccessA novel bystander effect in tamoxifen treatment: PPIB derived from ER+ cells attenuates ER− cells via endoplasmic reticulum stress-induced apoptosis
- Tinglin Yang
- , Wenhui Li
- & Tao Huang
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Article
| Open AccessExploiting epigenetic targets to overcome taxane resistance in prostate cancer
- Buse Cevatemre
- , Ipek Bulut
- & Ceyda Acilan
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Article
| Open AccessDeoxycytidine kinase inactivation enhances gemcitabine resistance and sensitizes mitochondrial metabolism interference in pancreatic cancer
- Suman Dash
- , Takeshi Ueda
- & Hitoshi Okada
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Article
| Open AccessRuxolitinib induces apoptosis and pyroptosis of anaplastic thyroid cancer via the transcriptional inhibition of DRP1-mediated mitochondrial fission
- Ya-wen Guo
- , Lei Zhu
- & Ming-hua Ge
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Article
| Open AccessBlockade of C5aR1 resets M1 via gut microbiota-mediated PFKM stabilization in a TLR5-dependent manner
- Jie Zhao
- , Chen Yao
- & Jing Yang
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Article
| Open AccessTranscription factor ATMIN facilitates chemoresistance in nasopharyngeal carcinoma
- Xue-Liang Fang
- , Qing-Jie Li
- & Ling-Long Tang
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Article
| Open AccessTargeting AXL induces tumor-intrinsic immunogenic response in tyrosine kinase inhibitor-resistant liver cancer
- Yunong Xie
- , Haofeng Wu
- & Man Tong
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Article
| Open AccessFSTL3 promotes tumor immune evasion and attenuates response to anti-PD1 therapy by stabilizing c-Myc in colorectal cancer
- Haiyang Li
- , Na Zheng
- & Shuli Zhao
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Review Article
| Open AccessRoles of exosomes in immunotherapy for solid cancers
- Cong Lyu
- , Haifeng Sun
- & Qiming Wang
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Article
| Open AccessTargeting FBXO22 enhances radiosensitivity in non-small cell lung cancer by inhibiting the FOXM1/Rad51 axis
- Yunshang Chen
- , Yun Zhou
- & Xiaohua Jie
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| Open AccessCYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma
- Yueshuo Li
- , Chenxing Yang
- & Ya Cao
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| Open AccessAURKA inhibition induces Ewing’s sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis
- Huimou Chen
- , Jing Hu
- & Zhihua Li
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Article
| Open AccessCollagen I-induced VCAN/ERK signaling and PARP1/ZEB1-mediated metastasis facilitate OSBPL2 defect to promote colorectal cancer progression
- Kang Lin
- , Yun Zhao
- & Luwei He
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Article
| Open AccessMDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner
- Jianfeng Shu
- , Jinni Jiang
- & Ting Cai
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| Open AccessUnexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control
- Daric J. Wible
- , Zalak Parikh
- & Shawn B. Bratton
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| Open Accessc-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer
- Yanping Gui
- , Xiaoping Qian
- & Li Zhao
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| Open AccessBACH2-mediated CD28 and CD40LG axes contribute to pathogenesis and progression of T-cell lymphoblastic leukemia
- Min Feng
- , Bailing Zhang
- & Han Zhang