DNA nanotechnology

Definition

DNA nanotechnology is a branch of nanotechnology concerned with the design, study and application of synthetic structures based on DNA. DNA nanotechnology takes advantage of the physical and chemical properties of DNA rather than the genetic information it carries.

Latest Research and Reviews

  • Reviews |

    Asymmetric chiroplasmonic structures comprising nanoparticles or nanorods can be assembled using DNA scaffolds by a range of methods. In this Review, these assembly methods, the chiroplasmonic properties of static and dynamically reconfigurable systems, theoretical modelling of the chiroplasmonic structures, their applications for sensing and information processing, and future perspectives are discussed.

    • Alessandro Cecconello
    • , Lucas V. Besteiro
    • , Alexander O. Govorov
    •  & Itamar Willner
  • Research |

    A metallo–DNA hybrid nanowire composed only of silver-mediated base pairs has been prepared and its crystal structure resolved by X-ray diffraction. The nanowire, which is 2 nm wide and whose length reaches the μm to mm scale, holds silver ions into uninterrupted one-dimensional arrays along the DNA helical axis.

    • Jiro Kondo
    • , Yoshinari Tada
    • , Takenori Dairaku
    • , Yoshikazu Hattori
    • , Hisao Saneyoshi
    • , Akira Ono
    •  & Yoshiyuki Tanaka
  • Research |

    Controlling liposome shape, arrangement and dynamics is important for biophysical studies and synthetic biology applications. Now, using a family of reconfigurable DNA nanocages as templates, spherical, tubular, toroidal and helical liposomes with predefined geometry have been produced. DNA-guided membrane fusion and bending is also demonstrated.

    • Zhao Zhang
    • , Yang Yang
    • , Frederic Pincet
    • , Marc C. Llaguno
    •  & Chenxiang Lin
    Nature Chemistry 9, 653–659
  • Research | | open

    The instability of DNA nanostructures in physiological environments has hampered their use as therapeutics and diagnostic agents in in vivo applications. Here, the authors show that coating DNA origami with oligolysine-PEG moieties improves their pharmacokinetic properties in mouse models.

    • Nandhini Ponnuswamy
    • , Maartje M. C. Bastings
    • , Bhavik Nathwani
    • , Ju Hee Ryu
    • , Leo Y. T. Chou
    • , Mathias Vinther
    • , Weiwei Aileen Li
    • , Frances M. Anastassacos
    • , David J. Mooney
    •  & William M. Shih
  • Protocols |

    In DNA-PAINT, transient binding of dye-labeled oligonucleotides to their target strands creates the ‘blinking’ required for stochastic nanoscopy. This protocol describes how to apply DNA-PAINT, from sample preparation to data processing.

    • Joerg Schnitzbauer
    • , Maximilian T Strauss
    • , Thomas Schlichthaerle
    • , Florian Schueder
    •  & Ralf Jungmann
    Nature Protocols 12, 1198–1228

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