DNA nanomachines

Definition

DNA nanomachines are nanorobots made entirely or partially of DNA. DNA nanomachines can switch between defined molecular conformations and can be used as sensing, computing, actuating or therapeutic nanodevices.

Latest Research and Reviews

  • Research | | open

    Responsive molecular machines can perform specific tasks triggered by environmental or chemical stimuli. Here, the authors show that antibodies can be used as inputs to modulate the binding of a molecular cargo to a designed DNA-based nanomachine, with potential applications in diagnostics and drug delivery.

    • Simona Ranallo
    • , Carl Prévost-Tremblay
    • , Andrea Idili
    • , Alexis Vallée-Bélisle
    •  & Francesco Ricci
  • Research |

    Although DNA nanotechnology has found many applications in developing functional structures, there has never been an independent device contained within a 3D crystal. Now, a self-assembled three-state device that can change the colour of its crystal by diffusion of DNA-ligated dyes has been reported, representing the potential to develop programmable nanomechanical devices.

    • Yudong Hao
    • , Martin Kristiansen
    • , Ruojie Sha
    • , Jens J. Birktoft
    • , Carina Hernandez
    • , Chengde Mao
    •  & Nadrian C. Seeman
    Nature Chemistry 9, 824–827
  • Research | | open

    Synthetic DNA nanomachines have been designed to perform a variety of tasks in vitro. Here, the authors build a nanomotor system that integrates a DNAzyme and DNA track on a gold nanoparticle, to facilitate cellular uptake, and apply it as a real-time miRNA imaging tool in living cells.

    • Hanyong Peng
    • , Xing-Fang Li
    • , Hongquan Zhang
    •  & X. Chris Le
  • Research | | open

    DNA circuits hold promise for advancing information-based molecular technologies, yet it is challenging to design and construct them in practice. Thubagere et al. build DNA strand displacement circuits using unpurified strands whose sequences are automatically generated from a user-friendly compiler.

    • Anupama J. Thubagere
    • , Chris Thachuk
    • , Joseph Berleant
    • , Robert F. Johnson
    • , Diana A. Ardelean
    • , Kevin M. Cherry
    •  & Lulu Qian
  • Research | | open

    Rotaxanes are interlocked molecules that can undergo sliding and rotational movements and can be used in artificial molecular machines and motors. Here, Simmel and co-workers show a rigid rotaxane structures consisting of DNA origami subunits that can slide over several hundreds of nanometres.

    • Jonathan List
    • , Elisabeth Falgenhauer
    • , Enzo Kopperger
    • , Günther Pardatscher
    •  & Friedrich C. Simmel

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