Research Highlight |
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Research Highlight |
Gene-edited organoids enable sensitive assessment of peptide hormone variation
- Olivia Tysoe
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Consensus Statement
| Open AccessConsensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
In this Expert Consensus Statement, the authors define 10 key characteristics (KCs) for endocrine-disrupting chemicals. They further describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs.
- Michele A. La Merrill
- , Laura N. Vandenberg
- & R. Thomas Zoeller
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Review Article |
The role of thyroglobulin in thyroid hormonogenesis
T3 and T4 are synthesized in the thyroid gland in a process that involves the iodoglycoprotein thyroglobulin. In this Review, we consider the role of thyroglobulin in thyroid hormonogenesis from evolutionary, biochemical, molecular, cellular and physiological angles.
- Cintia E. Citterio
- , Héctor M. Targovnik
- & Peter Arvan
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Perspective |
Endocrine disruptors and the future of toxicology testing — lessons from CLARITY–BPA
The aim of the Consortium Linking Academic and Regulatory Insights on Toxicity of BPA (CLARITY–BPA) was to provide a definitive evaluation of bisphenol A (BPA). In this Perspectives, the authors summarize the goals, design and problems of CLARITY–BPA.
- Laura N. Vandenberg
- , Patricia A. Hunt
- & Andrea C. Gore
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Review Article |
Liver X receptors in lipid signalling and membrane homeostasis
The liver X receptor (LXR) pathway is important for maintaining cholesterol homeostasis. In this Review, the authors discuss the role of LXRs in cholesterol and lipid metabolism and the emerging strategies to target the LXR pathway to treat metabolic diseases.
- Bo Wang
- & Peter Tontonoz
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News & Views |
Flame retardants and increased risk of thyroid cancer
Household dust contaminated with common flame retardants used in everyday household items has been found to be associated with increased risk of developing smaller, as well as more aggressive forms of papillary thyroid cancer in humans. These findings emphasize the need to consider the exposome when evaluating the increased incidence of thyroid cancer.
- Bilal B. Mughal
- & Barbara A. Demeneix
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Review Article |
Endocrine-disrupting chemicals and fatty liver disease
In this Review, Foulds et al. posit that endocrine-disrupting chemicals are an unappreciated driver of the development and progression of nonalcoholic fatty liver disease. Experimental animal studies supporting this association are discussed, together with the challenges of establishing a causal link in humans.
- Charles E. Foulds
- , Lindsey S. Treviño
- & Cheryl L. Walker
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News & Views |
Chemical contaminants — a toxic mixture for neurodevelopment
A mixture of chemicals commonly detected in human amniotic fluid has been found to perturb thyroid signalling, development of neurons and glia in the brain, and behavioural outcomes in offspring, when tested in a frog model of embryogenesis. The findings show the exquisite sensitivity of the developing organism to environmental contaminants.
- Morgan E. Hernandez
- & Andrea C. Gore
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Review Article |
Early-life exposure to EDCs: role in childhood obesity and neurodevelopment
Endocrine-disrupting chemicals (EDCs) can increase the risk of childhood diseases by disrupting hormone-mediated processes critical for growth and development. Here, Joseph Braun discusses epidemiological evidence of associations between early-life exposure to EDCs and childhood neurodevelopmental disorders and obesity.
- Joseph M. Braun
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Review Article |
Analgesic use — prevalence, biomonitoring and endocrine and reproductive effects
Concern exists about the possible link between intrauterine exposure to analgesics and congenital malformations. Here, Bernard Jégou and colleagues discuss the effects of mild analgesics (paracetamol and NSAIDs) on endocrine homeostasis and the reproductive system in animals and humans of both sexes, from fetal life to adulthood.
- David M. Kristensen
- , Séverine Mazaud-Guittot
- & Bernard Jégou
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News & Views |
A gold standard test for adrenal insufficiency in children?
Accurate testing of the integrity of the hypothalamic–pituitary–adrenal axis in children at risk of central adrenal insufficiency is difficult and a subject of debate. Findings of a new study by Di Iorgi et al. reveal the usefulness of a potential alternative to the insulin tolerance test—the glucagon stimulation test.
- Hedi L. Claahsen-van der Grinten
- & Barto J. Otten
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News & Views |
ACCORD Blood Pressure and ACCORD Lipid: how low can we go?
Lowering blood pressure to normal levels, below those currently recommended, does not reduce the risk of cardiovascular disease events in patients with type 2 diabetes mellitus. Nor does treating dyslipidemia with fibrate and statin combination therapy reduce the risk of cardiovascular disease events more than treatment with statin alone.
- Mariela Glandt
- & Itamar Raz
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