Accurate testing of the integrity of the hypothalamic–pituitary–adrenal axis in children at risk of central adrenal insufficiency is difficult and a subject of debate. Findings of a new study by Di Iorgi et al. reveal the usefulness of a potential alternative to the insulin tolerance test—the glucagon stimulation test.
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Claahsen-van der Grinten, H., Otten, B. A gold standard test for adrenal insufficiency in children?. Nat Rev Endocrinol 6, 605–606 (2010). https://doi.org/10.1038/nrendo.2010.152
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DOI: https://doi.org/10.1038/nrendo.2010.152