Consensus Statement
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Open Access
Featured
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Perspective |
Endocrine disruptors and the future of toxicology testing — lessons from CLARITY–BPA
The aim of the Consortium Linking Academic and Regulatory Insights on Toxicity of BPA (CLARITY–BPA) was to provide a definitive evaluation of bisphenol A (BPA). In this Perspectives, the authors summarize the goals, design and problems of CLARITY–BPA.
- Laura N. Vandenberg
- , Patricia A. Hunt
- & Andrea C. Gore
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News & Views |
Flame retardants and increased risk of thyroid cancer
Household dust contaminated with common flame retardants used in everyday household items has been found to be associated with increased risk of developing smaller, as well as more aggressive forms of papillary thyroid cancer in humans. These findings emphasize the need to consider the exposome when evaluating the increased incidence of thyroid cancer.
- Bilal B. Mughal
- & Barbara A. Demeneix
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News & Views |
Chemical contaminants — a toxic mixture for neurodevelopment
A mixture of chemicals commonly detected in human amniotic fluid has been found to perturb thyroid signalling, development of neurons and glia in the brain, and behavioural outcomes in offspring, when tested in a frog model of embryogenesis. The findings show the exquisite sensitivity of the developing organism to environmental contaminants.
- Morgan E. Hernandez
- & Andrea C. Gore
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Review Article |
Early-life exposure to EDCs: role in childhood obesity and neurodevelopment
Endocrine-disrupting chemicals (EDCs) can increase the risk of childhood diseases by disrupting hormone-mediated processes critical for growth and development. Here, Joseph Braun discusses epidemiological evidence of associations between early-life exposure to EDCs and childhood neurodevelopmental disorders and obesity.
- Joseph M. Braun
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Review Article |
Analgesic use — prevalence, biomonitoring and endocrine and reproductive effects
Concern exists about the possible link between intrauterine exposure to analgesics and congenital malformations. Here, Bernard Jégou and colleagues discuss the effects of mild analgesics (paracetamol and NSAIDs) on endocrine homeostasis and the reproductive system in animals and humans of both sexes, from fetal life to adulthood.
- David M. Kristensen
- , Séverine Mazaud-Guittot
- & Bernard Jégou
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Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
Increased risk with concurrent dietary and EDC exposures