Cell migration articles within Nature Materials

Featured

  • Article |

    Viscoelasticity is a universal mechanical feature of the extracellular matrix. Here the authors show that the extracellular matrix viscoelasticity guides tissue growth and symmetry breaking, a fundamental process in morphogenesis and oncogenesis.

    • Alberto Elosegui-Artola
    • , Anupam Gupta
    •  & David J. Mooney

  • News & Views |

    By maximizing cell–substrate force transmission, cancer cells can migrate towards either stiffer or softer substrate regions.

    • Amy E. M. Beedle
    •  & Pere Roca-Cusachs

  • Article
    | Open Access

    Collective cell migration in embryonic tissues is triggered by cell softening due to a microtubule deacetylation pathway involving the mechanosensitive ion channel Piezo1.

    • Cristian L. Marchant
    • , Abdul N. Malmi-Kakkada
    •  & Elias H. Barriga

  • Article |

    Directed cell movement known as durotaxis, typically associated with cellular migration in response to a substrate gradient of increasing stiffness, is now shown to also occur in the opposite direction, following a gradient of decreasing stiffness.

    • Aleksi Isomursu
    • , Keun-Young Park
    •  & David J. Odde

  • Article |

    Substrate-rigidity-dependent microtubule acetylation is now shown to be triggered by mechanosensing at focal adhesions, and in turn controls the mechanosensitivity of Yes-associated protein (YAP) translocation, focal adhesion distribution, actomyosin contractility and cell migration.

    • Shailaja Seetharaman
    • , Benoit Vianay
    •  & Sandrine Etienne-Manneville

  • News & Views |

    A molecular pathway has been identified in the regulation of unjamming to overcome cancer cell migration and proliferation arrest leading to collective cell invasion.

    • René Marc Mège

  • Article |

    A RAB5A-mediated, epidermal growth factor-dependent activation of endosomal ERK1/2 is identified as a key molecular route for a solid-to-liquid-like phase transition, sufficient to overcome kinetic and proliferation arrest in normal mammary epithelial assemblies and to promote collective invasion in breast carcinoma.

    • Andrea Palamidessi
    • , Chiara Malinverno
    •  & Giorgio Scita

  • Article |

    Increased cellular expression of RAB5A, an important regulator of endocytic processes, brings epithelial cells from a jammed state to coordinated motion, and can facilitate wound closure, gastrulation and migration in constrained environments.

    • Chiara Malinverno
    • , Salvatore Corallino
    •  & Giorgio Scita

  • News & Views |

    In atherosclerotic plaques, patterns of calcification — which have profound implications for plaque stability and vulnerability to rupture — are determined by the collagen's content and patterning throughout the plaque.

    • Jordan D. Miller

  • News & Views |

    Extracellular-matrix stiffness regulates cell behaviour even when decoupled from ligand density and tethering.

    • Sanjay Kumar

  • News & Views |

    Electric fields prompt epithelial cell populations to make coordinated movements such as U-turns.

    • Nir Gov

  • News & Views |

    Advances in photochemistry have profoundly impacted the way in which biology is studied. Now, a photoactivated enzymatic patterning method that offers spatiotemporal control over the presentation of bioactive proteins to direct cells in three-dimensional culture significantly expands the available chemical toolbox.

    • Daniel L. Alge
    •  & Kristi S. Anseth

  • News & Views |

    Cells at the edges of migrating epithelial sheets pull themselves towards unfilled space regardless of their direction of motion.

    • Eric R. Dufresne
    •  & Martin A. Schwartz

  • Article |

    The mechanical stresses within and between cells inside an advancing cellular monolayer are mapped experimentally. Cellular migration is found to be oriented in the direction of maximum principal stress indicating that cells collectively migrate to maintain minimal local intercellular shear stress.

    • Dhananjay T. Tambe
    • , C. Corey Hardin
    •  & Xavier Trepat

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