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Investigating the nature of active forces in tissues reveals how contractile cells can form extensile monolayers
It is now revealed, using cell cultures and in silico models, that weakening intercellular contacts is a fundamental process essential for switching from extensile to contractile tissue behaviour.
- Lakshmi Balasubramaniam
- , Amin Doostmohammadi
- & Benoît Ladoux
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News & Views |
Molecular basis for fluidization of cancer cells
A molecular pathway has been identified in the regulation of unjamming to overcome cancer cell migration and proliferation arrest leading to collective cell invasion.
- René Marc Mège
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Endocytic reawakening of motility in jammed epithelia
Increased cellular expression of RAB5A, an important regulator of endocytic processes, brings epithelial cells from a jammed state to coordinated motion, and can facilitate wound closure, gastrulation and migration in constrained environments.
- Chiara Malinverno
- , Salvatore Corallino
- & Giorgio Scita
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News & Views |
Towards the void
Cells at the edges of migrating epithelial sheets pull themselves towards unfilled space regardless of their direction of motion.
- Eric R. Dufresne
- & Martin A. Schwartz
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Collective cell guidance by cooperative intercellular forces
The mechanical stresses within and between cells inside an advancing cellular monolayer are mapped experimentally. Cellular migration is found to be oriented in the direction of maximum principal stress indicating that cells collectively migrate to maintain minimal local intercellular shear stress.
- Dhananjay T. Tambe
- , C. Corey Hardin
- & Xavier Trepat
Cell clusters softening triggers collective cell migration in vivo