Research Highlights |
Featured
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News & Views |
The bio-mission of diode lasers
Diode lasers represent a viable alternative to light sources used in many biomedical applications. Their ongoing development will further increase their importance, offering not only multiple wavelength ranges, but also higher power levels.
- Rachel Won
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Commentary |
Analog optical computing
The concept of optical computing is reintroduced with an important new twist — optical computing not as a digital machine, but as an analog engine able to serve as a hardware accelerator for existing electronic computers.
- Daniel R. Solli
- & Bahram Jalali
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Letter |
Optical control of excitation waves in cardiac tissue
Optogenetics makes it possible for dynamic patterns of visible light to control the behaviour of excitation waves in heart cells.
- Rebecca A. B. Burton
- , Aleksandra Klimas
- & Gil Bub
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Correspondence |
Reply to 'Mechanism for microtsunami-induced intercellular mechanosignalling'
- Justin C. Luo
- , Elliot L. Botvinick
- & Vasan Venugopalan
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Correspondence |
Mechanism for microtsunami-induced intercellular mechanosignalling
- Hao He
- , Keiichi Nakagawa
- & Keisuke Goda
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Commentary |
Photonics in cardiovascular medicine
The use of photonics technology is bringing new capabilities and insights to cardiovascular medicine. Intracoronary imaging and sensing, laser ablation and optical pacing are just some of the functions being explored to help diagnose and treat conditions of the heart and arteries.
- Gijs van Soest
- , Evelyn Regar
- & Antonius F. W. van der Steen
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Letter |
High-power sub-two-cycle mid-infrared pulses at 100 MHz repetition rate
A compact source that generates sub-two-cycle-duration pulses with an average power of 0.1 W spanning 6.8–16.4 μm combines the properties of power scalability, high repetition rate and phase coherence for the first time in this spectral region.
- I. Pupeza
- , D. Sánchez
- & J. Biegert
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Review Article |
Guidestar-assisted wavefront-shaping methods for focusing light into biological tissue
Optical scattering limits the ability to image or focus beneath one millimetre of tissue in biomedical optics. This Review summarizes recently developed 'guidestar' mechanisms that provide feedback for intra-tissue focusing.
- Roarke Horstmeyer
- , Haowen Ruan
- & Changhuei Yang
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Article |
Direct optical nanoscopy with axially localized detection
Researchers exploit direct stochastic optical reconstruction microscopy and dedicated detection of super-critical-angle fluorescence emission to enable direct optical nanoscopy with axially localized detection.
- N. Bourg
- , C. Mayet
- & S. Lévêque-Fort
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Article |
Seeing through chaos in multimode fibres
The prediction of light propagation up to hundreds of millimetres within straight or even deformed segments of multimode fibres is demonstrated. The concept is applied in an endoscope and exceptional resolution and footprint are obtained.
- Martin Plöschner
- , Tomáš Tyc
- & Tomáš Čižmár
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Review Article |
Chemically sensitive bioimaging with coherent Raman scattering
Coherent Raman imaging techniques have evolved to become powerful tools for biomedical imaging without the need for labelling.
- Charles H. Camp Jr
- & Marcus T. Cicerone
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Article |
Imaging deep within a scattering medium using collective accumulation of single-scattered waves
Using the collective accumulation of single-scattered waves, scientists manage to image deep within a scattering medium, achieving an imaging depth 11.5 times the scattering mean free path and a near-diffraction-limit resolution of 1.5 µm.
- Sungsam Kang
- , Seungwon Jeong
- & Wonshik Choi
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Article |
Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms
A swept light-sheet microscopy scheme allows volumetric imaging of living samples at high speed.
- Matthew B. Bouchard
- , Venkatakaushik Voleti
- & Elizabeth M. C. Hillman
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Article |
Photoacoustically guided wavefront shaping for enhanced optical focusing in scattering media
Nonlinear photoacoustic signals are used to ‘guide’ laser light to a tight focal spot in scattering media.
- Puxiang Lai
- , Lidai Wang
- & Lihong V. Wang
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News & Views |
Raman extraordinaire
Fluctuations in light transmitted through a plasmonic nanohole-structure provide a way of mapping Raman transitions in nanoscale objects, including single proteins.
- Alexander Weigel
- & Philipp Kukura
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Article |
High-throughput imaging of heterogeneous cell organelles with an X-ray laser
70,000 diffraction patterns captured over twelve minutes at the Linac Coherent Light Source yield reconstructions of the smallest single biological objects imaged with an X-ray laser.
- Max F. Hantke
- , Dirk Hasse
- & Inger Andersson
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Letter |
Time-reversed adapted-perturbation (TRAP) optical focusing onto dynamic objects inside scattering media
Combining the principles of time reversal and adaptive control with a spatial light modulator makes it possible to focus light onto moving objects hidden within a scattering medium. The approach could prove useful for medical applications.
- Cheng Ma
- , Xiao Xu
- & Lihong V. Wang
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News & Views |
Through-skull brain imaging
The use of carbon nanotubes makes it possible to perform fluorescent imaging of cerebral vasculature of mice through their intact skulls. The high spatial and temporal resolution of the non-invasive technique may prove useful for studies of stroke and other brain disorders.
- Steen J. Madsen
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Interview |
Femtophotography
A burst-mode camera developed in Japan called STAMP with a femtosecond frame rate could become a powerful tool for studying ultrafast dynamics. Nature Photonics asked Keiichi Nakagawa about the technique.
- Noriaki Horiuchi
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Article |
Through-skull fluorescence imaging of the brain in a new near-infrared window
Near-infrared photoluminescence from carbon nanotubes makes it possible to optically image the vasculature in the brain directly through the skull.
- Guosong Hong
- , Shuo Diao
- & Hongjie Dai
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Article |
High-throughput optical screening of cellular mechanotransduction
A pulsed laser technique that induces mechanical stress in cells offers high-throughput testing of the effect of molecular agents on mechanotransduction in cells.
- Jonathan L. Compton
- , Justin C. Luo
- & Vasan Venugopalan
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Article |
High-speed coherent Raman fingerprint imaging of biological tissues
A high-resolution, broadband imaging system based on coherent anti-Stokes Raman spectroscopy performs rapid, chemically specific imaging of biological tissue. It employs three-colour excitation and operates across the entire biological window.
- Charles H. Camp Jr
- , Young Jong Lee
- & Marcus T. Cicerone
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Article |
Truncated-correlation photothermal coherence tomography for deep subsurface analysis
A photothermal imaging scheme that is analogous to optical coherence tomography can be used to construct the three-dimensional structures of bone and burn-affected skin.
- Sreekumar Kaiplavil
- & Andreas Mandelis
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News & Views |
Watching the brain at work
It has been 20 years since near-infrared spectroscopy was first used to investigate human brain function. The technique has subsequently been extended to offer high-resolution imaging of the cortex and has now become a viable alternative to functional magnetic resonance imaging.
- Robert J. Cooper
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Article |
Mapping distributed brain function and networks with diffuse optical tomography
High-resolution diffuse optical tomography employing a large array of light sources and detectors arranged around the head can perform functional brain imaging. It provides an alternative to magnetic resonance imaging for monitoring activity in different areas of the brain.
- Adam T. Eggebrecht
- , Silvina L. Ferradal
- & Joseph P. Culver
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Article |
Photodynamic therapy by in situ nonlinear photon conversion
An investigation of the use of nonlinear upconversion effects like second-harmonic generation and four-wave mixing within biological tissue indicates that it should be possible to perform photodynamic therapy with near-infrared laser light at greater depths than previously.
- A. V. Kachynski
- , A. Pliss
- & P. N. Prasad
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Letter |
Isotropic three-dimensional super-resolution imaging with a self-bending point spread function
By exploiting a self-bending point spread function based on Airy beams, a three-dimensional super-resolution fluorescence imaging is realized. A three-dimensional localization precision in the range 10–15 nm was obtained at an imaging depth of 3 µm from ∼2,000 photons per localization.
- Shu Jia
- , Joshua C. Vaughan
- & Xiaowei Zhuang
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News & Views |
White-light diffraction tomography
A clever extension to a classic phase-contrast microscope allows speckle-free three-dimensional quantitative phase imaging of living cells in a tomographic imaging mode.
- Arno Bouwens
- & Theo Lasser
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News & Views |
Tunable lifetime nanocrystals
Tuning the luminescence lifetimes of upconversion nanocrystals through lanthanide doping provides new opportunities for optical multiplexing in the time domain for applications in imaging and security marking.
- Renren Deng
- & Xiaogang Liu
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Letter |
Tunable lifetime multiplexing using luminescent nanocrystals
Control over the luminescence lifetimes of upconversion nanocrystals allows a new form of temporal multiplexing for imaging and data-storage applications.
- Yiqing Lu
- , Jiangbo Zhao
- & Dayong Jin
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Article |
Controlling light in scattering media non-invasively using the photoacoustic transmission matrix
An approach is demonstrated that allows the optical transmission matrix to be noninvasively measured over a large volume inside complex samples using a standard photoacoustic imaging set-up. This approach opens the way towards deep-tissue imaging and light delivery utilizing endogenous optical contrast.
- T. Chaigne
- , O. Katz
- & S. Gigan
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Letter |
Multiphoton absorption in amyloid protein fibres
Two-, three- and higher multiphoton absorption processes are shown to occur in amyloid protein fibres, which are thought to play a role in various diseases, including Alzheimer's and Parkinson's diseases. The nonlinear optical behaviour of such proteins may also be useful for fabricating photonics devices.
- Piotr Hanczyc
- , Marek Samoc
- & Bengt Norden
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