Featured
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News & Views |
Listening to microorganisms with light
Combining photoacoustic excitation with optomechanics enables the mechanical modes associated with entire microorganisms to be detected, demonstrating that mechanical spectroscopy allows us to identify microorganisms and characterize their life stages.
- Eduardo Gil-Santos
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Article |
Enhanced detection of fluorescence fluctuations for high-throughput super-resolution imaging
Super-resolution imaging based on autocorrelation with two-step deconvolution (SACD) enables recording super-resolution images with 128-nm spatial resolution over a field of view of 2.0 mm × 1.4 mm within a 10-min acquisition time.
- Weisong Zhao
- , Shiqun Zhao
- & Haoyu Li
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Article
| Open Access
Brilliant whiteness in shrimp from ultra-thin layers of birefringent nanospheres
The strong birefringence of liquid crystalline nanospheres in the body of the Pacific cleaner shrimp enables brilliant whiteness by overcoming undesirable optical crowding effects.
- Tali Lemcoff
- , Lotem Alus
- & Benjamin A. Palmer
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Correspondence |
Open-source browser-based software simplifies fluorescence correlation spectroscopy data analysis
- Dominic Waithe
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Obituary |
In memory of Watt Wetmore Webb
Webb’s work helped fundamentally reshape basic research and advanced manufacturing in the generation and application of photonics across disciplines, from fundamental and applied physics to the biosciences.
- Jeffrey Squier
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Article |
Ultrafast viscosity measurement with ballistic optical tweezers
A structured-light-based detection of a particle trapped in optical tweezers enables ultrafast velocity and viscosity determination.
- Lars S. Madsen
- , Muhammad Waleed
- & Warwick P. Bowen
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Article |
Monitoring contractility in cardiac tissue with cellular resolution using biointegrated microlasers
The incorporation of microsphere lasers into heart cells allows all-optical recording of cardiac contraction with cellular resolution. [This summary has been amended from ‘microdisk’ to ‘microsphere’ lasers.]
- Marcel Schubert
- , Lewis Woolfson
- & Malte C. Gather
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Letter |
Graphene-based metal-induced energy transfer for sub-nanometre optical localization
Using graphene as the ‘metal’ layer can increase the localization accuracy of metal-induced energy transfer, enabling axial localization of single emitters and measurement of the thickness of lipid bilayers with ångström accuracy.
- Arindam Ghosh
- , Akshita Sharma
- & Jörg Enderlein
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News & Views |
Photonic amyloids
Emerging data reveal that amyloid fibrils possess intrinsic photonic activity, showing luminescence over a wide range of the electromagnetic spectrum from the ultraviolet to the near-infrared.
- Per Hammarström
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Article |
Ultraviolet–visible–near-infrared optical properties of amyloid fibrils shed light on amyloidogenesis
Two optical signatures of amyloid fibres—luminescence in the blue and a near-infrared signal, which can be observed in in vitro and in vivo tissues—are reported. The findings allow for staining-free characterization of amyloid deposits in human samples and could open the door to innovative diagnostic strategies for neurodegenerative diseases.
- Jonathan Pansieri
- , Véronique Josserand
- & Vincent Forge
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Article |
Interferometric scattering microscopy reveals microsecond nanoscopic protein motion on a live cell membrane
Interferometric scattering microscopy is employed to track proteins in live cell membranes, demonstrating tracking of transmembrane epidermal growth factor receptors with nanometre precision in all three dimensions at up to microsecond speeds and for durations of tens of minutes.
- Richard W. Taylor
- , Reza Gholami Mahmoodabadi
- & Vahid Sandoghdar
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Article |
Femtosecond laser crosslinking of the cornea for non-invasive vision correction
Laser-driven crosslinking of molecules at the cornea offers a non-invasive alternative to surgical correction of the refractive power of the eye.
- Chao Wang
- , Mikhail Fomovsky
- & Sinisa Vukelic
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Article |
Background suppression in fluorescence nanoscopy with stimulated emission double depletion
Stimulated emission double depletion addresses the issue of background in super-resolution imaging and quantitative microscopy through implementation of a two-pulse sequence in a modified stimulated emission depletion set-up. The measured background intensity is removed from each voxel in the acquired images thanks to time-resolved detection.
- Peng Gao
- , Benedikt Prunsche
- & G. Ulrich Nienhaus
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Article |
High-throughput imaging of heterogeneous cell organelles with an X-ray laser
70,000 diffraction patterns captured over twelve minutes at the Linac Coherent Light Source yield reconstructions of the smallest single biological objects imaged with an X-ray laser.
- Max F. Hantke
- , Dirk Hasse
- & Inger Andersson
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Brillouin light scattering anisotropy microscopy for imaging the viscoelastic anisotropy in living cells