Featured
-
-
Article
| Open AccesscircPLIN2 promotes clear cell renal cell carcinoma progression by binding IGF2BP proteins and miR-199a-3p
- Bin Zhao
- , Cong Huang
- & Wei Zhang
-
Article
| Open AccessLipid desaturation regulates the balance between self-renewal and differentiation in mouse blastocyst-derived stem cells
- Chanchal Thomas Mannully
- , Reut Bruck-Haimson
- & Arieh Moussaieff
-
Article
| Open AccessRNA binding protein HuD mediates the crosstalk between β cells and islet endothelial cells by the regulation of Endostatin and Serpin E1 expression
- Myeongwoo Jung
- , Seungyeon Ryu
- & Eun Kyung Lee
-
Article
| Open Accessp53 triggers mitochondrial apoptosis following DNA damage-dependent replication stress by the hepatotoxin methyleugenol
- Max J. Carlsson
- , Anastasia S. Vollmer
- & Jörg Fahrer
-
Article
| Open AccessMetabolic regulation of cholestatic liver injury by D-2-hydroxyglutarate with the modulation of hepatic microenvironment and the mammalian target of rapamycin signaling
- Xinbei Tian
- , Ying Wang
- & Yongtao Xiao
-
Article
| Open AccessGenuine selective caspase-2 inhibition with new irreversible small peptidomimetics
- Elodie Bosc
- , Julie Anastasie
- & Etienne D. Jacotot
-
Article
| Open AccessFMR1 promotes the progression of colorectal cancer cell by stabilizing EGFR mRNA in an m6A-dependent manner
- Yuhan Hu
- , Qingzu Gao
- & Jiateng Zhong
-
Article
| Open AccessGlioblastoma cell motility depends on enhanced oxidative stress coupled with mobilization of a sulfurtransferase
- Mirca S. Saurty-Seerunghen
- , Thomas Daubon
- & Marie-Pierre Junier
-
Article
| Open AccessIKCa channels control breast cancer metabolism including AMPK-driven autophagy
- Dominic Gross
- , Helmut Bischof
- & Robert Lukowski
-
Article
| Open AccessMMP7 cleavage of amino-terminal CD95 death receptor switches signaling toward non-apoptotic pathways
- Shoji F. Kenji
- , Keerthi Kurma
- & Patrick Legembre
-
Article
| Open AccessTension of plus-end tracking protein Clip170 confers directionality and aggressiveness during breast cancer migration
- Yunfeng Hu
- , Qiu Xie
- & Jun Guo
-
Article
| Open AccessThe ataxia-linked E1081Q mutation affects the sub-plasma membrane Ca2+-microdomains by tuning PMCA3 activity
- Francesca Vallese
- , Lorenzo Maso
- & Ernesto Carafoli
-
Review Article
| Open AccessUnveiling caspase-2 regulation by non-coding RNAs
- Yun Zhao
- , Shanel Dhani
- & Boris Zhivotovsky
-
Article
| Open AccessUSP15 regulates p66Shc stability associated with Drp1 activation in liver ischemia/reperfusion
- Xinyao Tian
- , Yan Zhao
- & Shusen Zheng
-
Review Article
| Open AccessInterplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma
- Yu-Huei Liu
- , Chun-Mei Hu
- & Wen-Hwa Lee
-
Article
| Open AccessFBXW7 inactivation induces cellular senescence via accumulation of p53
- Longyuan Gong
- , Danrui Cui
- & Yongchao Zhao
-
Article
| Open AccessDominant-negative p53-overexpression in skeletal muscle induces cell death and fiber atrophy in rats
- Henning T. Langer
- , Agata A. Mossakowski
- & Keith Baar
-
Article
| Open AccessCircular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling
- Su’an Tang
- , Xiaoyu Nie
- & Changhai Ding
-
Article
| Open AccessThe deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ
- Jin Li
- , Yibin Dai
- & Hongbing Jiang
-
Article
| Open AccessThe hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progression
Mitochondrial interaction of HKDC1 is essential for its pro-proliferative role in LC. When HKDC1 is ablated in liver cancer cells, mitochondrial dysfunction occurs which results in decrease ATP in the cells. The cancer cells react to decreased cellular energy by increasing glucose uptake. Also due to mitochondrial dysfunction there is enhanced ER stress and ER-mitochondrial interaction, leading to more calcium flux into the mitochondria. This multi-pronged effects of HKDC1 ablation leads to decreased cellular proliferation in LC.
- Md. Wasim Khan
- , Alexander R. Terry
- & Brian T. Layden
-
Article
| Open AccessDeficiency of PPP6C protects TNF-induced necroptosis through activation of TAK1
- Yonggang Zou
- , Qi Zheng
- & Hai Song
-
Article
| Open AccessHydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics
- Francesca Ferrante
- , Benedetto Daniele Giaimo
- & Tilman Borggrefe
-
Article
| Open AccessBimodal regulation of axonal transport by the GDNF-RET signalling axis in healthy and diseased motor neurons
- Elena R. Rhymes
- , Andrew P. Tosolini
- & Giampietro Schiavo
-
Article
| Open AccessRestoring the epigenetically silenced lncRNA COL18A1-AS1 represses ccRCC progression by lipid browning via miR-1286/KLF12 axis
- Yuenan Liu
- , Jun Wang
- & Xiaoping Zhang
-
Article
| Open AccessHuman RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
- Yanxiang Meng
- , Christopher R. Horne
- & James M. Murphy
-
Article
| Open AccessProteomic analysis reveals USP7 as a novel regulator of palmitic acid-induced hepatocellular carcinoma cell death
- Sandhini Saha
- , Rohit Verma
- & Tushar Kanti Maiti
-
Article
| Open AccessOTUB1 augments hypoxia signaling via its non-canonical ubiquitination inhibition of HIF-1α during hypoxia adaptation
- Xing Liu
- , Hongyan Deng
- & Wuhan Xiao
-
Article
| Open AccessCt-OATP1B3 promotes high-grade serous ovarian cancer metastasis by regulation of fatty acid beta-oxidation and oxidative phosphorylation
- Yutang Huang
- , Yan Du
- & Lanxiang Wu
-
Article
| Open AccessDysfunction of the energy sensor NFE2L1 triggers uncontrollable AMPK signaling and glucose metabolism reprogramming
- Lu Qiu
- , Qiufang Yang
- & Yuanming Qi
-
Article
| Open AccessAntibiotic pretreatment attenuates liver ischemia–reperfusion injury by Farnesoid X receptor activation
- Hanyi Liu
- , Jinglin Wang
- & Haozhen Ren
-
Article
| Open AccessSex differences in global metabolomic profiles of COVID-19 patients
- Rocio Diaz Escarcega
- , Pedram Honarpisheh
- & Andrey S. Tsvetkov
-
Article
| Open AccessMammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia
- Lei Sun
- , He Yang
- & Min Zhang
-
Article
| Open AccessFBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development
- Jing Ji
- , Jing Shen
- & Bin Liu
-
Article
| Open AccessThe caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions
- Madeleine Eichler
- , Ute Distler
- & Gergely Imre
-
Meeting Report
| Open Access9th International Multithematic Scientific Bio-Medical Congress (IMBMC), Nicosia, Cyprus, 2021
- Michael Luster
- , Karen Bang Strand
- & Ioannis Patrikios
-
Article
| Open AccessAnti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance
- Qincai Dong
- , Dapei Li
- & Xuan Liu
-
Article
| Open AccessThe Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL
- Annette V. Jacobsen
- , Catia L. Pierotti
- & James M. Murphy
-
Article
| Open AccessAMTB, a TRPM8 antagonist, suppresses growth and metastasis of osteosarcoma through repressing the TGFβ signaling pathway
- Yujie Liu
- , Ao Leng
- & Jianru Xiao
-
Article
| Open AccessAn integrated bioinformatic investigation of mitochondrial solute carrier family 25 (SLC25) in colon cancer followed by preliminary validation of member 5 (SLC25A5) in tumorigenesis
- Yan-Jie Chen
- , Wei-Feng Hong
- & Li Liang
-
Article
| Open AccessNovel anti-apoptotic L-DOPA precursors SuperDopa and SuperDopamide as potential neuroprotective agents for halting/delaying progression of Parkinson’s disease
- Tom Wiesen
- & Daphne Atlas
-
Article
| Open AccessEvolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog
- Qiang Zhang
- , Dimitrios-Ilias Balourdas
- & Andreas C. Joerger
-
Article
| Open AccessATG7-enhanced impaired autophagy exacerbates acute pancreatitis by promoting regulated necrosis via the miR-30b-5p/CAMKII pathway
- Liang Ji
- , Zhi-hong Wang
- & Gang Wang
-
Article
| Open AccessMolecular basis of apoptotic DNA fragmentation by DFF40
- Hyun Ji Ha
- & Hyun Ho Park
-
Article
| Open AccessMethyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages
- Kai Ai
- , Jian Pan
- & Dongshan Zhang
-
Article
| Open AccessDeubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma
- Kai Guo
- , Yinghua Wei
- & Chun-Ping Cui
-
Article
| Open AccessGalectin-1 confers resistance to doxorubicin in hepatocellular carcinoma cells through modulation of P-glycoprotein expression
- Pablo Carabias
- , María V. Espelt
- & María F. Troncoso
-
Article
| Open AccessHERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer
- Zhiyuan Zhang
- , Guodong He
- & Jianmin Xu
-
Review Article
| Open AccessPathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective
- Yiqi Yang
- , Ziyang Lin
- & Jiao Guo
-
Review Article
| Open AccessDouble-edge sword roles of iron in driving energy production versus instigating ferroptosis
- Shuping Zhang
- , Wei Xin
- & Sijin Liu
Browse broader subjects
Browse narrower subjects
- Biocatalysis
- Biogeochemistry
- Bioinorganic chemistry
- Biophysical chemistry
- Carbohydrates
- Chemical modification
- Cytokines
- DNA
- Enzyme mechanisms
- Enzymes
- Glycobiology
- Glycomics
- Histocytochemistry
- Hormones
- Immunochemistry
- Ion channels
- Isoenzymes
- Kinases
- Lipidomics
- Lipids
- Metabolomics
- Metals
- Neurochemistry
- Peptides
- Prions
- Proteases
- Protein folding
- Proteins
- Proteolysis
- Proteomics
- RNA
- Structural biology