Article
|
Open Access
Featured
-
-
Article
| Open AccessGlioblastoma cell motility depends on enhanced oxidative stress coupled with mobilization of a sulfurtransferase
- Mirca S. Saurty-Seerunghen
- , Thomas Daubon
- & Marie-Pierre Junier
-
Article
| Open AccessHydroxylation of the NOTCH1 intracellular domain regulates Notch signaling dynamics
- Francesca Ferrante
- , Benedetto Daniele Giaimo
- & Tilman Borggrefe
-
Article
| Open AccessAsparagine synthetase regulates lung-cancer metastasis by stabilizing the β-catenin complex and modulating mitochondrial response
In the Wnt pathway, phosphorylation of GSK3β(S9) is very important to stabilize β-catenin complex, ASNS can upregulate phosphorylation of AKT on Ser473, then promote GSK3β phosphorylation on Ser9 to stabilize β-catenin complex. When Wnt pathway is activated, ASNS elevates p-DRP1(637) and decreases p-DRP1(616) to suppress mitochondrial fission.
- Dong-Jing Cai
- , Zi-Yu Zhang
- & Min Li
-
Article
| Open AccessMolecular basis of apoptotic DNA fragmentation by DFF40
- Hyun Ji Ha
- & Hyun Ho Park
-
Article
| Open AccessUSP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer
- Yu-Ting Huang
- , An-Chieh Cheng
- & Wei-Yi Chen
-
Article
| Open AccessFear-of-intimacy-mediated zinc transport controls fat body cell dissociation through modulating Mmp activity in Drosophila
- Tian Wei
- , Xiaowen Ji
- & Guiran Xiao
-
Article
| Open AccessEndotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia
- Yandong Lai
- , Xiuying Li
- & Chunbin Zou
-
Article
| Open AccessFlavin dependency undermines proteome stability, lipid metabolism and cellular proliferation during vitamin B2 deficiency
- Adrían Martínez-Limón
- , Giulia Calloni
- & R. Martin Vabulas
-
Article
| Open AccessWTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2
- Teresa Maria Carusone
- , Giovanna Cardiero
- & Giuseppe Manco
-
Article
| Open AccessKeratinocyte transglutaminase 2 promotes CCR6+ γδT-cell recruitment by upregulating CCL20 in psoriatic inflammation
- Ji-Woong Shin
- , Mee-ae Kwon
- & In-Gyu Kim
-
Article
| Open AccessTargeting a moonlighting function of aldolase induces apoptosis in cancer cells
- Agnieszka Gizak
- , Janusz Wiśniewski
- & Dariusz Rakus
-
Original Article
| Open AccessCircular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma
- Liang Shi
- , Peijian Yan
- & Xiujun Cai
-
Original Article
| Open AccessCaspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity
- Claire H Wilson
- , Andrej Nikolic
- & Sharad Kumar
-
Original Article
| Open AccessInhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice
- Fengjie Hao
- , Francisco Javier Cubero
- & Yulia A Nevzorova
-
Original Article
| Open AccessTransglutaminase 2 mediates UV-induced skin inflammation by enhancing inflammatory cytokine production
- Seok-Jin Lee
- , Ki Baek Lee
- & In-Gyu Kim
-
Original Article
| Open AccessIncreased 15-lipoxygenase-1 expression in chondrocytes contributes to the pathogenesis of osteoarthritis
- Kaizhe Chen
- , Yufei Yan
- & Lei Guo
-
Original Article
| Open AccessMolecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2
- Matthew Merski
- , Cátia Moreira
- & Sandra Macedo-Ribeiro
-
Original Article
| Open AccessCalcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration
- Luigi Racioppi
- , William Lento
- & Nelson Chao
-
Original Article
| Open AccessReciprocal amplification of caspase-3 activity by nuclear export of a putative human RNA-modifying protein, PUS10 during TRAIL-induced apoptosis
- Sujata Jana
- , Andrew C Hsieh
- & Ramesh Gupta
-
Original Article
| Open AccessBerberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition
- Dong Hou
- , Guangwei Xu
- & Changshun Shao
-
Original Article
| Open AccessTat-protein disulfide-isomerase A3: a possible candidate for preventing ischemic damage in the spinal cord
- Dae Young Yoo
- , Su Bin Cho
- & Seung Myung Moon
-
Original Article
| Open AccessExecutioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine
- Mark A Miles
- & Christine J Hawkins
-
Original Article
| Open AccessKnockdown of SIRT7 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the Wnt/β-catenin signaling pathway
- Erman E M Chen
- , Wei Zhang
- & Deting D T Xue
-
Original Article
| Open AccessPDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR)
- Philip Kranz
- , Fabian Neumann
- & Ulf Brockmeier
-
Original Article
| Open AccessLoss of PHD3 in myeloid cells dampens the inflammatory response and fibrosis after hind-limb ischemia
- Angelika Beneke
- , Annemarie Guentsch
- & Dörthe M Katschinski
-
Original Article
| Open AccessKlotho enhances FoxO3-mediated manganese superoxide dismutase expression by negatively regulating PI3K/AKT pathway during tacrolimus-induced oxidative stress
- Sun Woo Lim
- , Long Jin
- & Chul Woo Yang
-
Review
| Open AccessAcid sphingomyelinase mediates human CD4+ T-cell signaling: potential roles in T-cell responses and diseases
- Aiping Bai
- & Yuan Guo
-
Original Article
| Open AccessKeratin 23 promotes telomerase reverse transcriptase expression and human colorectal cancer growth
- Ningning Zhang
- , Rui Zhang
- & Xiaonan Cui
-
Original Article
| Open AccessWWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response
- Szymon Janczar
- , Jaya Nautiyal
- & Hani Gabra
-
Original Article
| Open AccessThe role of MAP2 kinases and p38 kinase in acute murine liver injury models
- Jun Zhang
- , Robert W M Min
- & Neil Kaplowitz
-
Original Article
| Open AccessHistone deacetylase 3 overexpression in human cholangiocarcinoma and promotion of cell growth via apoptosis inhibition
- Yuyao Yin
- , Mingming Zhang
- & Xiaoping Zou
-
Original Article
| Open AccessOocyte-specific deletion of furin leads to female infertility by causing early secondary follicle arrest in mice
- Tie-Gang Meng
- , Meng-Wen Hu
- & Qing-Yuan Sun
-
Original Article
| Open AccessHIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination
- Mayilaadumveettil Nishana
- , Namrata M Nilavar
- & Sathees C Raghavan
-
Original Article
| Open AccessDamage-induced neuronal endopeptidase (DINE) enhances axonal regeneration potential of retinal ganglion cells after optic nerve injury
- Aoi Kaneko
- , Sumiko Kiryu-Seo
- & Hiroshi Kiyama
-
Original Article
| Open AccessRACK1 depletion in the ribosome induces selective translation for non-canonical autophagy
- Hag Dong Kim
- , EunBin Kong
- & Joon Kim
-
Original Article
| Open AccessDrosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization
- Juyeon Jo
- , Seol Hee Im
- & Michael J Galko
-
Original Article
| Open AccessWithaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences
- Yue Yu
- , Shashank P Katiyar
- & Renu Wadhwa
-
Original Article
| Open AccessFoot-and-mouth disease virus infection inhibits LGP2 protein expression to exaggerate inflammatory response and promote viral replication
- Zixiang Zhu
- , Chuntian Li
- & Haixue Zheng
-
Original Article
| Open AccessDepletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesis
- Wenhua Yu
- , Fang Zhang
- & Bing Zhang
-
Original Article
| Open AccessG9A promotes tumor cell growth and invasion by silencing CASP1 in non-small-cell lung cancer cells
- Tianhao Huang
- , Peng Zhang
- & Fan Zhang
-
Original Article
| Open AccessThe role of autophagy in asparaginase-induced immune suppression of macrophages
- Ping Song
- , Ziyu Wang
- & Dianwen Ju
-
Original Article
| Open AccessFunctional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death
- Saskia Klutzny
- , Ralf Lesche
- & Patrick Steigemann
-
Original Article
| Open AccessMetabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase
- Li Q Zhang
- , Leon Van Haandel
- & Shui Qing Ye
-
Original Article
| Open AccessmiR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1
- Hong-fu Xie
- , Ying-zi Liu
- & Ji Li
-
News and Commentary
| Open AccessCaspases play in traffic
- Catherine M Duclos
- , Audrey Champagne
- & Jean-Bernard Denault
-
Original Article
| Open AccessEndogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis
- Kai Hu
- , Xianqiong Gong
- & Li Zhang
-
Original Article
| Open AccessNuclear Drosha enhances cell invasion via an EGFR-ERK1/2-MMP7 signaling pathway induced by dysregulated miRNA-622/197 and their targets LAMC2 and CD82 in gastric cancer
- Liyun Xu
- , Yixuan Hou
- & Manran Liu
-
Original Article
| Open AccessNeuroblastoma cells depend on HDAC11 for mitotic cell cycle progression and survival
- Theresa M Thole
- , Marco Lodrini
- & Hedwig E Deubzer
-
Original Article
| Open AccessMetacaspase-binding peptide inhibits heat shock-induced death in Leishmania (L.) amazonensis
- Mauricio S Peña
- , Guilherme C Cabral
- & Beatriz S Stolf