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Eltrombopag directly activates BAK and induces apoptosis
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Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid
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TRAP1 S-nitrosylation as a model of population-shift mechanism to study the effects of nitric oxide on redox-sensitive oncoproteins
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The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit and protects cancer cells from apoptosis
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Evolutionary history of the p53 family DNA-binding domain: insights from an Alvinella pompejana homolog
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Molecular basis of apoptotic DNA fragmentation by DFF40
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The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling
- Yu Zhang
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Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome
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MCL1 binds and negatively regulates the transcriptional function of tumor suppressor p73
- Hayley Widden
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Article
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WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2
- Teresa Maria Carusone
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Original Article
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Molecular motion regulates the activity of the Mitochondrial Serine Protease HtrA2
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Meeting Report
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News and Commentary
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Other bricks for the correct construction of the mitochondrial permeability transition pore complex
- Giampaolo Morciano
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Original Article
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Structural insight into an evolutionarily ancient programmed cell death regulator – the crystal structure of marine sponge BHP2 bound to LB-Bak-2
- Sofia Caria
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Original Article
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Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction
- A Y Robin
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Original Article
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A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation
- X Gao
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Original Article
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Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening
- L-J Liu
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Review
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Structural biology of the Bcl-2 family and its mimicry by viral proteins
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Three-dimensional structure of Bax-mediated pores in membrane bilayers
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Original Article
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Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study
- H N Noristani
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Original Article
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Extraribosomal functions associated with the C terminus of the 37/67 kDa laminin receptor are required for maintaining cell viability
- J Scheiman
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Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids