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  • EULAR’s 2023 updated recommendations for the non-pharmacological treatment of hip and knee osteoarthritis reiterates and confirms, in an abbreviated form, what we have known for more than a decade. Unfortunately, the abbreviated format of the updated recommendations lacks specificity and clinical usefulness. More detailed guidance could have facilitated wider uptake and improved care.

    • Marius Henriksen
    News & Views
  • In this Evidence-Based Guideline article, an international multidisciplinary working group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases presents recommendations for the diagnosis, monitoring and treatment of osteoporosis in men.

    • Nicholas R. Fuggle
    • Charlotte Beaudart
    • Nicholas C. Harvey
    Evidence-based Guidelines
  • Characteristic patterns of joint involvement exist in different forms of arthritis. Research now indicates that epigenetic programming of synovial fibroblasts diversifies their response to inflammatory cascades, leading to this anatomical variation in arthritis and its response to treatment.

    • Chrissy Bolton
    • Adam P. Croft
    News & Views
  • In 2006, a linear immunological continuum of autoinflammatory and autoimmune disorders ranging from monogenic diseases of innate immunity at one end to monogenic diseases of adaptive immunity at the other end was proposed to classify these conditions. Deep immunophenotyping has now revealed a cell-based nosology of these disorders.

    • Michael F. McDermott
    News & Views
  • Tyrosine kinase 2 (TYK2), a Janus kinase family member, is involved in immune signalling and is implicated in autoimmune diseases such as systemic lupus erythematosus; inhibitors of TYK2 show promise in treating various diseases and potentially offer advantages over other Janus kinase inhibitors.

    • Eric Morand
    • Joseph F. Merola
    • Roy Fleischmann
    Review Article
  • New research has identified apolipoprotein E expressed by fibroblasts and macrophages in the infrapatellar fat pad and synovium as a pathogenetic mediator and potential therapeutic target in knee osteoarthritis.

    • Robert Phillips
    Research Highlight
  • Results of a new study indicate that eosinophils have a role in maintaining bone homeostasis through their inhibitory effects on bone-resorbing osteoclasts.

    • Sarah Onuora
    Research Highlight
  • Beyond the traditional classification of monogenic or complex, many genetic diseases can be considered genetically transitional disease. In this Perspective, the authors consider the application of the genetically transitional disease model to rheumatic diseases and the potential implications for patient care, genetic counselling and research.

    • Timothy B. Niewold
    • Ivona Aksentijevich
    • Qingping Yao
    Perspective
  • Immunoengineering involves the design of materials with specific properties relating to the immune system. In this Review the authors consider the application of immunoengineering to systemic autoimmune diseases via site-specific and antigen-specific immunoregulation, the facilitation of immune cell therapy, novel approaches to immunodiagnostics and the generation of models to study autoimmunity.

    • David A. McBride
    • Ryan M. Jones
    • Nisarg J. Shah
    Review Article
  • The World Health Organization (WHO) has published new guidelines for the non-surgical management of chronic primary low back pain in adults in primary and community care settings. Although the guidelines are commendable, they lack guidance on when to suspect and how to avoid missing important secondary causes of back pain.

    • Mohamad Bittar
    • Atul Deodhar
    News & Views
  • Age-related B cells (ABCs) have pathogenic roles in autoimmune diseases. Research has now identified ZEB2 as the transcription factor that mediates differentiation into ABCs.

    • Robert Phillips
    Research Highlight
  • A meta-analysis of data from six genome-wide association study cohorts implicates several signalling pathways, including Hedgehog and Notch signalling, in Dupuytren disease.

    • Sarah Onuora
    Research Highlight
  • Deep learning is a powerful technique with great potential for the analysis and interpretation of rheumatological images. To successfully use deep learning, rheumatologists should understand the tasks involved in image processing and the potential confounders and limitations that can affect the analysis of clinical data.

    • Berend C. Stoel
    • Marius Staring
    • Annette H. M. van der Helm-van Mil
    Review Article
  • Juvenile idiopathic arthritis treatment has evolved with new therapies, early remission goals and global efforts, including randomized trials and a treat-to-target strategy. This Review summarizes current evidence and therapeutic approaches to the management of non-systemic phenotypes of juvenile idiopathic arthritis.

    • Susan Shenoi
    • Gerd Horneff
    • Angelo Ravelli
    Review Article
  • This Review discusses the interplay of the gut microbiome and the immune system in the context of systemic lupus erythematosus. Dysbiosis and gut-barrier dysfunction are implicated in promoting disease and are potential therapeutic targets.

    • Gregg J. Silverman
    • Doua F. Azzouz
    • Abhimanyu Amarnani
    Review Article