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Advancing precision rheumatology through tissue and blood profiling

Nature Reviews Rheumatology (2024)Cite this article

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Multidimensional and single-cell profiling of peripheral blood and inflamed tissues is a powerful and high-resolution tool for the stratification of patients with autoimmune rheumatic diseases into distinct cellular and/or molecular endotypes. The road towards precision rheumatology is long, but the time has come to enter the territory of clinical validation.

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Fig. 1: A roadmap towards precision rheumatology.

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Authors and Affiliations

  1. Hospital for Special Surgery, Arthritis & Tissue Degeneration, New York, NY, USA

    George D. Kalliolias

  2. Weill Cornell Medical College, Department of Medicine, New York, NY, USA

    George D. Kalliolias

  3. Regeneron Pharmaceuticals, Tarrytown, NY, USA

    George D. Kalliolias

  4. Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece

    Athanasios G. Papavassiliou

Authors
  1. George D. Kalliolias
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  2. Athanasios G. Papavassiliou
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Correspondence to Athanasios G. Papavassiliou.

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Competing interests

G.D.K. is a full-time employee and shareholder at Regeneron Pharmaceuticals. A.G.P. declares no competing interests.

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Kalliolias, G.D., Papavassiliou, A.G. Advancing precision rheumatology through tissue and blood profiling. Nat Rev Rheumatol (2024). https://doi.org/10.1038/s41584-024-01115-7

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