In a new study, hand MRI showed that nearly half — 26 of 55 patients (47%) — with cutaneous psoriasis have subclinical inflammatory lesions, despite the cohort having been carefully screened to exclude any patients with clinical evidence of inflammatory joint disease. The risk of developing psoriatic arthritis (PsA) within 1 year was 55% in patients with both evidence of synovitis on hand MRI and symptoms of arthralgia, versus only 15% in patients lacking these two features. The researchers' report warns, however, that no causal relationship can be inferred from their observations.
References
Faustini, F. et al. Subclinical joint inflammation in patients with psoriasis without concomitant psoriatic arthritis: a cross-sectional and longitudinal analysis. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2015-208821 (2016)
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Barranco, C. Nearly half of those with psoriasis at risk of PsA?. Nat Rev Rheumatol 12, 194 (2016). https://doi.org/10.1038/nrrheum.2016.40
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DOI: https://doi.org/10.1038/nrrheum.2016.40