Psoriasis

Definition

Psoriasis is an autoimmune disease in which the skin becomes inflamed, producing red, flaky areas. It affects 1-2% of the population and is thought to be caused by misguided T cell attacks on the skin.

Latest Research and Reviews

  • Research | | open

    TWEAK is a TNF family member that binds the NFκB signalling receptor Fn14. Here the authors show that TWEAK is central to skin inflammation in mouse models of atopic dermatitis and psoriasis and causes similar pathology when injected subcutaneously into mice.

    • Daniel Sidler
    • , Ping Wu
    • , Rana Herro
    • , Meike Claus
    • , Dennis Wolf
    • , Yuko Kawakami
    • , Toshiaki Kawakami
    • , Linda Burkly
    •  & Michael Croft
  • Reviews |

    Psoriasis is a chronic, immune-mediated disease that can severely affect patient quality of life. Various kinds of skin manifestations are possible; psoriatic arthritis is a common but underdiagnosed comorbidity. Treatments for psoriasis include topical agents, phototherapy and systemic and biologic agents.

    • Jacqueline E. Greb
    • , Ari M. Goldminz
    • , James T. Elder
    • , Mark G. Lebwohl
    • , Dafna D. Gladman
    • , Jashin J. Wu
    • , Nehal N. Mehta
    • , Andrew Y. Finlay
    •  & Alice B. Gottlieb
  • Research | | open

    Imiquimod exacerbates IL-23-induced skin inflammation and models psoriasis in mice. Here the authors show that this pathology is not dependent on resident dendritic cells, but on CCR6-induced immigration of monocyte-derived cells.

    • Tej Pratap Singh
    • , Howard H. Zhang
    • , Izabela Borek
    • , Peter Wolf
    • , Michael N. Hedrick
    • , Satya P. Singh
    • , Brian L. Kelsall
    • , Bjorn E. Clausen
    •  & Joshua M. Farber
  • Research | | open

    IL-12 and IL-23 share the common p40 subunit yet have distinct immunological functions with IL-12 typically contributing to Th1 responses and IL-23 to Th17 responses. Here the authors show that current p40 based therapies for psoriasis are counterproductive owing to an IFN-γ-independent tissue protective function of IL-12 in skin.

    • Paulina Kulig
    • , Stephanie Musiol
    • , Sandra Nicole Freiberger
    • , Bettina Schreiner
    • , Gabor Gyülveszi
    • , Giancarlo Russo
    • , Stanislav Pantelyushin
    • , Kenji Kishihara
    • , Francesca Alessandrini
    • , Thomas Kündig
    • , Federica Sallusto
    • , Günther F.L. Hofbauer
    • , Stefan Haak
    •  & Burkhard Becher

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