Current Issue

Featured article

Fat targets for skeletal health

Masanobu Kawai, Maureen J. Devlin & Clifford J. Rosen

The homeostatic processes of adipogenesis and osteoblastogenesis are tightly linked, as discussed in this Review. Research into the boneᾹfat network has led to the elucidation of pathways that could be pharmacologically targeted in an attempt to enhance bone mass and reduce osteoporotic fracture risk.

Current Issue

Featured article

Management of RA medications in pregnant patients

Monika Østensen & Frauke Förger

The treatment strategy for a patient with rheumatoid arthritis who plans to conceive or is already pregnant must be tailored according to not only disease activity but also which drugs are compatible with pregnancy. The safety of various therapeutic agents during pregnancy is discussed in this Review, as well as issues of handling inadvertent exposure to potentially fetotoxic drugs and managing flares of disease activity during pregnancy.

Current Issue

Also in this issue

News and Views: Is combined oral contraceptive use linked to SLE incidence?

News and Views: The risk of herpes zoster: another cost of anti-TNF therapy?

News and Views: Hyaluronic acid is not effective in symptomatic hip OA

Current Issue

Also in this issue

Hierarchical microimaging of bone structure and function

Ralph Müller

The use of high-resolution imaging techniques will lead to a better understanding of the relative contribution of the different hierarchical levels to bone competence. Such information could help improve predictions of fracture risk, clarify the pathophysiology of skeletal diseases, and define the response to therapy. This Review focuses on three-dimensional approaches to hierarchical biomechanical imaging in the study of microstructural and ultrastructural bone failure.