Metabolic regulation of inflammation

Latest Reviews

  • Consensus Statement | | open

    In this Consensus Statement, a group of experts propose that high-quality immunoassays, rather than indirect immunofluorescence, should be used as the primary screening method for detecting anti-neutrophil cytoplasmic antibodies when diagnosing patients with suspected granulomatosis with polyangiitis or microscopic polyangiitis.

    • Xavier Bossuyt
    • , Jan-Willem Cohen Tervaert
    • , Yoshihiro Arimura
    • , Daniel Blockmans
    • , Luis Felipe Flores-Suárez
    • , Loïc Guillevin
    • , Bernhard Hellmich
    • , David Jayne
    • , J. Charles Jennette
    • , Cees G. M. Kallenberg
    • , Sergey Moiseev
    • , Pavel Novikov
    • , Antonella Radice
    • , Judith Anne Savige
    • , Renato Alberto Sinico
    • , Ulrich Specks
    • , Pieter van Paassen
    • , Ming-hui Zhao
    • , Niels Rasmussen
    • , Jan Damoiseaux
    •  & Elena Csernok
  • Review |

    Rapid progress in the fields of giant cell arteritis and polymyalgia rheumatica has resulted in the introduction of imaging techniques into routine clinical practice and in promising reports on the efficacy of biologic agents for treatment. Further research should further advance our understanding of the epidemiology, pathogenesis, imaging and treatment of these diseases.

    • Christian Dejaco
    • , Elisabeth Brouwer
    • , Justin C. Mason
    • , Frank Buttgereit
    • , Eric L. Matteson
    •  & Bhaskar Dasgupta
  • Review |

    Epigenetic alterations are increasingly being associated with the pathogenesis of inflammatory rheumatic diseases. In this Review, Ballestar and Li outline the current state of research into the role of epigenetics in such diseases and the possibility of epigenetic-targeting therapies.

    • Esteban Ballestar
    •  & Tianlu Li
  • Review |

    Autoantibodies are known to regulate the function of G protein-coupled receptors (GPCRs), but the involvement of such functional autoantibodies in autoimmune disorders is not fully understood. In this Review, the author discuss evidence showing agonistic and antagonistic effects of anti-GPCR functional autoantibodies in the pathogenesis of different rheumatic diseases.

    • Otavio Cabral-Marques
    •  & Gabriela Riemekasten
  • Review |

    The amount of clinical, serological and experimental evidence linking periodontitis to rheumatoid arthritis is constantly increasing. In this Review, Potempa and colleagues lay out the case for periodontal pathogens in the pathogenesis of rheumatoid arthritis.

    • Jan Potempa
    • , Piotr Mydel
    •  & Joanna Koziel

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