Since the surprising finding that injured axons in the mature central nervous system can re-grow, there has been dramatic progress in our understanding of the molecular, cellular and circuitry level responses to injuries to the adult mammalian central nervous system. This special Focus issue highlights recent developments in this field, with a view to understanding the underlying mechanisms that will enable the development of appropriate therapeutic strategies.
Research highlights
Nerve regeneration: A dual role for reactive astrocytes
Jane Qiu
doi:10.1038/nrn1977
Nature Reviews Neuroscience 7, 594-595
Nerve Regeneration: A strain on regeneration
Alison Rowan
doi:10.1038/nrn1972
Nature Reviews Neuroscience 7, 596-597
Reviews
Can regenerating axons recapitulate developmental guidance during recovery from spinal cord injury?
Noam Y. Harel and Stephen M. Strittmatter
doi:10.1038/nrn1957
Nature Reviews Neuroscience 7, 603-616
Glial inhibition of CNS axon regeneration
Glenn Yiu and Zhigang He
doi:10.1038/nrn1956
Nature Reviews Neuroscience 7, 617-627
Therapeutic interventions after spinal cord injury
Sandrine Thuret, Lawrence D. F. Moon and Fred H. Gage
doi:10.1038/nrn1955
Nature Reviews Neuroscience 7, 628-643
Perspectives
Spinal cord repair strategies: why do they work?
Elizabeth J. Bradbury and Stephen B. McMahon
doi:10.1038/nrn1964
Nature Reviews Neuroscience 7, 644-653
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