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Romosozumab — getting there but not quite yet

Nature Reviews Endocrinology volume 12, pages 691–692 (2016)Cite this article

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In a recent study by Cosman and colleagues, romosozumab — a humanized monoclonal antibody targeting sclerostin — is shown to reduce the risk of vertebral and clinical fractures at 12 months compared with placebo. However, the low fracture risk of study participants necessitates the completion of an on-going clinical trial before romosozumab can be fully adopted into clinical practice.

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Authors and Affiliations

  1. Department of Medicine, Division of Endocrinology, Center for Bone Quality, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, Netherlands

    Socrates E. Papapoulos

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  1. Socrates E. Papapoulos
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Correspondence to Socrates E. Papapoulos.

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Competing interests

S.E.P. has received consulting and speaking fees from Amgen and UCB, and consulting fees from Mereo Biopharma.

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Papapoulos, S. Romosozumab — getting there but not quite yet. Nat Rev Endocrinol 12, 691–692 (2016). https://doi.org/10.1038/nrendo.2016.179

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