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Adipose tisssue

Controlling brown adipose tissue size through EPAC1

Nature Reviews Endocrinology volume 20, pages 259–260 (2024)Cite this article

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A new study by Reverte-Salisa and colleagues identifies a molecular mechanism through which the cAMP-mediating protein EPAC1 controls the size of brown and beige adipose tissue. This finding opens the door for the development of pharmacological interventions to prevent the decline of brown adipose tissue in obesity and ageing, and thereby improve metabolic health.

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Fig. 1: EPAC1 controls brown and beige adipose tissue size.

References

  1. Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277–359 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Villarroya, F., Cereijo, R., Villarroya, J. & Giralt, M. Brown adipose tissue as a secretory organ. Nat. Rev. Endocrinol. 13, 26–35 (2017).

    Article  CAS  PubMed  Google Scholar 

  3. Giralt, M. & Villarroya, F. White, brown, beige/brite: different adipose cells for different functions? Endocrinology 154, 2992–3000 (2013).

    Article  CAS  PubMed  Google Scholar 

  4. Betz, M. J. & Enerbäck, S. Human brown adipose tissue: what we have learned so far. Diabetes 64, 2352–2360 (2015).

    Article  CAS  PubMed  Google Scholar 

  5. Becher, T. et al. Brown adipose tissue is associated with cardiometabolic health. Nat. Med. 27, 58–65 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Collins, S. & Surwit, R. S. The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Prog. Horm. Res. 56, 309–328 (2001).

    Article  CAS  PubMed  Google Scholar 

  7. Reverte-Salisa, L. et al. EPAC1 enhances brown fat growth and beige adipogenesis. Nat. Cell Biol. 26, 113–123 (2024).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Géloën, A., Collet, A. J., Guay, G. & Bukowiecki, L. J. Beta-adrenergic stimulation of brown adipocyte proliferation. Am. J. Physiol. 254, C175–C182 (1988).

    Article  PubMed  Google Scholar 

  9. Nedergaard, J. & Cannon, B. UCP1 mRNA does not produce heat. Biochim. Biophys. Acta 1831, 943–949 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. Robichaux, W. G. III. & Cheng, X. Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development. Physiol. Rev. 98, 919–1053 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biomedicine, and Institute of Biomedicine (IBUB), University of Barcelona, Barcelona, Spain

    Francesc Villarroya & Marta Giralt

  2. CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Madrid, Spain

    Francesc Villarroya & Marta Giralt

Authors
  1. Francesc Villarroya
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  2. Marta Giralt
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Correspondence to Francesc Villarroya.

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The authors declare no competing interests.

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Villarroya, F., Giralt, M. Controlling brown adipose tissue size through EPAC1. Nat Rev Endocrinol 20, 259–260 (2024). https://doi.org/10.1038/s41574-024-00971-3

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