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Antibacterial action, along with restoration of redox and immune homeostasis, is achieved using a lipid–nanozyme hybrid for the healing of diabetic foot ulcers.
Therapies for treating bacterial infection and increasing wound healing are needed. Here the authors report a liposozyme that combines reactive oxygen species generation and scavenging for antibacterial action and modulation of redox and immune homeostasis, increasing wound healing.
Increased nutrient uptake of cancer cells offers a possible therapeutic target. Here, the authors designed a nanoparticle to deliver phenylboronic-acid-modified cholesterol which reacts in cancer cells to trigger Gaucher disease-like metabolic damage to tumour cells, demonstrating potential application.
Oral antidotes for consumption-related acute alcohol intoxication are needed. Here, the study presents amyloid fibrils of β-lactoglobulin, a milk-derived protein decorated by single-site iron, as a catalytic platform for alcohol detoxification in vivo and prophylactic protection against alcohol damage.
Silver nanowires self-assembled on microscale elastomer pores, through in situ phase separation, yield highly elastic porous nanocomposite conductors with ultralow percolation threshold and high stretchability. This material is highly conductive, strain-insensitive and fatigue-tolerant, and holds promise for strain-resilient, wireless, battery-free bioelectronics.
A flow-through redox-neutral electrochemical reactor–electrodialysis system has been developed to recover water, alkali and acids from hypersaline wastewaters. This accelerates a shift in ‘zero-discharge’ technology from energy-intensive steam-driven to energy-efficient electrically driven processes.
By manipulating the glass transition of the electrolyte, nanometre-resolution electrochemical ion implantation doping can be achieved in various polymeric semiconductors.
The ability to vaccinate against multiple related pathogens is a significant advantage. Here, the authors report on quartets of linked receptor-binding domains attached to designed nanocages using SpyTag/SpyCatcher links, demonstrating effective vaccination against similar viruses as well as the variant of concern.
The emission wavelengths of semiconductor lasers based on group-IV materials can be efficiently reconfigured by using strained nanomechanical resonators.
Ex vivo engineering of T cells for adoptive T-cell therapy without pre-activation is challenging and hinders therapeutic efficacy. Here, using nanowires, the delivery of microRNAs to primary naïve mouse and human CD8+ T cells without pre-activation for immune protection against pathogens is demonstrated.
Toroidic phases and their phase transitions are notoriously hard to study in natural materials. Now, a direct-kagome spin ice provides access to two low-temperature toroidal phases, ferrotoroidicity and paratoroidicity, as well as to toroidic phase transitions.
Biobased materials are of interest for many applications. Here the authors report insect-derived peptides that self-assemble into hollow nanocapsules through a gradient-driven, single-step, solvent exchange process, enabling the encapsulation of diverse cargoes with potential for drug delivery applications.
A simple manipulation of an electrolyte’s glass transition enables nanoresolved electrochemical ion implantation doping in a variety of polymeric semiconductors.
Acid-etching-driven nanosurface reconstruction of perovskite quantum-dot pure-red LEDs facilitates a peak external quantum efficiency of 28.5% and a half-lifetime of 30 h at 100 cd m−2 luminance, enabling highly efficient solution-processed active-matrix perovskite displays.
Plasmonic tunnel junctions integrated with a monolayer semiconductor are found to emit photons with energies exceeding the input electrical potential. This peculiar phenomenon is ascribed to being triggered by inelastic electron tunnelling dipoles inducing optically forbidden transitions in the carrier injection electrode.
A method for overcoming antibiotic resistance uses multimodal nanoparticles that target bacterial defence mechanisms while enhancing the innate immune response.
Antimicrobial resistance is becoming more prevalent. Here the authors use multimodal nanoparticles to modulate the infected microenvironment, recruit neutrophils and alleviate hypoxia to restore neutrophil function, demonstrating therapeutic efficacy against MRSA infections in mice.
A single-walled carbon nanotube spring stores three times more mechanical energy than a lithium-ion battery, while offering wide temperature stability and posing no explosion risk.