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| What makes the metabolic syndrome field tick? In this special feature of Nature Medicine, we set out to uncover the papers with the most impact in the discipline and to find out the funding priorities of the countries that are most affected by this health problem. The cover shows a transverse section of skeletal muscle, a key organ for glucose homeostasis. Image courtesy of Thomas Deerinck and Mark Ellisman, University of California, San Diego. |
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| Editorials | Top |
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Truth in numbers p1
doi:10.1038/nm0106-1a
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What it takes to make an impact p1
doi:10.1038/nm0106-1b
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(65K)
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| News | Top |
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US ponders unlocking the gates to prisoner research p3
Emily Waltz
Published online: 29 December 2005 | doi:10.1038/nm0106-3
Abstract | Full text | PDF
(141K)
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South Korean scandal rocks stem cell community p4
David Cyranoski
Published online: 29 December 2005 | doi:10.1038/nm0106-4a
Abstract | Full text | PDF
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Unchecked by guidelines, Indian stem cell scientists rush ahead p4
T V Padma
Published online: 29 December 2005 | doi:10.1038/nm0106-4b
Abstract | Full text | PDF
(122K)
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New rules propose greater scrutiny for NIH grant recipients p5
Alan Dove
Published online: 29 December 2005 | doi:10.1038/nm0106-5a
Abstract | Full text | PDF
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Reshuffle at infectious disease center ruffles many feathers p5
Emma Marris
Published online: 29 December 2005 | doi:10.1038/nm0106-5b
Abstract | Full text | PDF
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Scientists, activists sue South Africa's AIDS 'denialists' p6
James Watson
Published online: 29 December 2005 | doi:10.1038/nm0106-6a
Abstract | Full text | PDF
(156K)
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Low morale at US agency revives dormant scientist group p6
George S. Mack
Published online: 29 December 2005 | doi:10.1038/nm0106-6b
Abstract | Full text | PDF
(156K)
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News In Brief p7
doi:10.1038/nm0106-7
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News Feature: Hormone in the hot seat pp8 - 9
Apoorva Mandavilli
Published online: 29 December 2005 | doi:10.1038/nm0106-8
Abstract | Full text | PDF
(112K)
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Profile: Janet Rowley p10
Kris Novak
Published online: 29 December 2005 | doi:10.1038/nm0106-10
Abstract | Full text | PDF
(93K)
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| Book Review | Top |
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Microbes fight back p11doi:10.1038/nm0106-11
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(79K)
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| News and Views | Top |
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Decoy receptor springs to life and eases fibrosis pp13 - 14
Thomas T MacDonald
doi:10.1038/nm0106-13
Abstract | Full text | PDF
(269K)
See also: Article by Fichtner-Feigl et al. |
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Breaking the rules of cancer pp14 - 15
David R Shaffer
& Pier Paolo Pandolfi
doi:10.1038/nm0106-14
Abstract | Full text | PDF
(215K)
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Vessel tone and remodeling pp16 - 17
Geoffrey Burnstock
doi:10.1038/nm0106-16
Abstract | Full text | PDF
(416K)
See also: Letter by Yamamoto et al. |
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A channel to neurodegeneration pp17 - 18
Ariel Y Deutch
& Danny G Winder
doi:10.1038/nm0106-17
Abstract | Full text | PDF
(221K)
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Envoys of metastasis p18
Allison Alcivar
doi:10.1038/nm0106-18
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(204K)
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One enzyme inactivates two antibiotics pp19 - 20
Keith P Klugman
& Bruce R Levin
doi:10.1038/nm0106-19
Abstract | Full text | PDF
(94K)
See also: Article by Robicsek et al. |
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Research Highlights p21
doi:10.1038/nm0106-21
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(90K)
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| Special Feature: Introduction | Top |
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Metabolic syndrome p26
doi:10.1038/nm0106-26
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| Special Feature: News | Top |
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Rimonabant adds appetizing choice to slim obesity market p27
Meredith Wadman
Published online: 29 December 2005 | doi:10.1038/nm0106-27
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Inbred Israeli families aid research on rare diseases p28
Luba Vikhanski
Published online: 29 December 2005 | doi:10.1038/nm0106-28a
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Growing safety concerns stir caution on gastric bypass surgery p28
Meredith Wadman
Published online: 29 December 2005 | doi:10.1038/nm0106-28b
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(178K)
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People to watch p29
doi:10.1038/nm0106-29
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(385K)
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| Special Feature: News and Views | Top |
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RBP4, an unexpected adipokine pp30 - 31
Yoshikazu Tamori, Hiroshi Sakaue
& Masato Kasuga
doi:10.1038/nm0106-30
Abstract | Full text | PDF
(230K)
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Are all fats created equal? pp32 - 33
Kevin G Murphy
& Stephen R Bloom
doi:10.1038/nm0106-32
Abstract | Full text | PDF
(385K)
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The tangled path to glucose production pp33 - 34
Michihiro Matsumoto
& Domenico Accili
doi:10.1038/nm0106-33
Abstract | Full text | PDF
(138K)
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Sirt1: a metabolic master switch that modulates lifespan pp34 - 36
Ingo B Leibiger
& Per-Olof Berggren
doi:10.1038/nm0106-34
Abstract | Full text | PDF
(494K)
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MicroRNAs: 'ribo-regulators' of glucose homeostasis pp36 - 38
Benoit R Gauthier
& Claes B Wollheim
doi:10.1038/nm0106-36
Abstract | Full text | PDF
(269K)
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Foxa2, a novel transcriptional regulator of insulin sensitivity pp38 - 39
Pere Puigserver
& Joseph T Rodgers
doi:10.1038/nm0106-38
Abstract | Full text | PDF
(201K)
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ARNT misbehavin' in diabetic beta cells pp39 - 40
Michael P Czech
doi:10.1038/nm0106-39
Abstract | Full text | PDF
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Stressed out about obesity and insulin resistance pp41 - 42
Carl de Luca
& Jerrold M Olefsky
doi:10.1038/nm0106-41
Abstract | Full text | PDF
(568K)
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The humoral side of insulin resistance pp43 - 44
Mitchell A Lazar
doi:10.1038/nm0106-43
Abstract | Full text | PDF
(215K)
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Improving metabolism by increasing energy expenditure pp44 - 45
Johan Auwerx
doi:10.1038/nm0106-44
Abstract | Full text | PDF
(124K)
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Fast predators or fast food, the fit still survive pp46 - 47
Carlos Bernal-Mizrachi
& Clay F Semenkovich
doi:10.1038/nm0106-46
Abstract | Full text | PDF
(273K)
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How diabetes went to our heads pp47 - 49
Randy J Seeley
& Matthias Tschöp
doi:10.1038/nm0106-47
Abstract | Full text | PDF
(898K)
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Did a muscle fuel gauge conquer the brain? pp50 - 51
Alessandro Pocai, Evan David Muse
& Luciano Rossetti
doi:10.1038/nm0106-50
Abstract | Full text | PDF
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Developmental programming of the hypothalamus: a matter of fat pp52 - 53
Tamas L Horvath
& Jens C Bruning
doi:10.1038/nm0106-52
Abstract | Full text | PDF
(355K)
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When the Clock stops ticking, metabolic syndrome explodes pp54 - 55
Bart Staels
doi:10.1038/nm0106-54
Abstract | Full text | PDF
(161K)
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Klotho-induced insulin resistance: a blessing in disguise? pp56 - 57
Roger H Unger
doi:10.1038/nm0106-56
Abstract | Full text | PDF
(176K)
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| Special Feature: Tables | Top |
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Notable metabolism papers 2003-2005 pp58 - 61
doi:10.1038/nm0106-58
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| Special Feature: Commentary | Top |
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Epidemiologic and economic consequences of the global epidemics of obesity and diabetes pp62 - 66
Derek Yach, David Stuckler
& Kelly D Brownell
doi:10.1038/nm0106-62
Abstract | Full text | PDF
(268K)
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NIH research on obesity and type 2 diabetes: providing the scientific evidence base for actions to improve health pp67 - 69
Allen M Spiegel
& Elizabeth G Nabel
doi:10.1038/nm0106-67
Abstract | Full text | PDF
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Diabetes research investment in the European Union pp70 - 72
Philippe A Halban, Ele Ferrannini
& Jørn Nerup
doi:10.1038/nm0106-70
Abstract | Full text | PDF
(669K)
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Combating diabetes and obesity in Japan pp73 - 74
Yoshio Yazaki
& Takashi Kadowaki
doi:10.1038/nm0106-73
Abstract | Full text | PDF
(143K)
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| Special Feature: Market Analysis | Top |
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Diabetes and obesity: the twin epidemics pp75 - 80
Simon Smyth
& Andrew Heron
doi:10.1038/nm0106-75
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(365K)
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| Articles | Top |
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Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase pp83 - 88
Ari Robicsek, Jacob Strahilevitz, George A Jacoby, Mark Macielag, Darren Abbanat, Chi Hye Park, Karen Bush
& David C Hooper
Published online: 20 December 2005 | doi:10.1038/nm1347
Abstract | Full text | PDF
(202K)
| Supplementary Information
See also: News and Views by Klugman & Levin |
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Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation pp89 - 98
Jennifer J Trowbridge, Anargyros Xenocostas, Randall T Moon
& Mickie Bhatia
Published online: 11 December 2005 | doi:10.1038/nm1339
Abstract | Full text | PDF
(579K)
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IL-13 signaling through the IL-13 2 receptor is involved in induction of TGF- 1 production and fibrosis pp99 - 106
Stefan Fichtner-Feigl, Warren Strober, Koji Kawakami, Raj K Puri
& Atsushi Kitani
Published online: 04 December 2005 | doi:10.1038/nm1332
Abstract | Full text | PDF
(435K)
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See also: News and Views by MacDonald |
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TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes pp107 - 113
Yoshimi Nakagawa, Hitoshi Shimano, Tomohiro Yoshikawa, Tomohiro Ide, Mariko Tamura, Mika Furusawa, Takashi Yamamoto, Noriyuki Inoue, Takashi Matsuzaka, Akimitsu Takahashi, Alyssa H Hasty, Hiroaki Suzuki, Hirohito Sone, Hideo Toyoshima, Naoya Yahagi
& Nobuhiro Yamada
Published online: 04 December 2005 | doi:10.1038/nm1334
Abstract | Full text | PDF
(872K)
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A role for the scaffolding adapter GAB2 in breast cancer pp114 - 121
Mohamed Bentires-Alj, Susana G Gil, Richard Chan, Zhigang C Wang, Yongping Wang, Naoko Imanaka, Lyndsay N Harris, Andrea Richardson, Benjamin G Neel
& Haihua Gu
Published online: 20 December 2005 | doi:10.1038/nm1341
Abstract | Full text | PDF
(551K)
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| Letters | Top |
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Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer pp122 - 127
George V Thomas, Chris Tran, Ingo K Mellinghoff, Derek S Welsbie, Emily Chan, Barbara Fueger, Johannes Czernin
& Charles L Sawyers
Published online: 11 December 2005 | doi:10.1038/nm1337
Abstract | Full text | PDF
(300K)
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A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy pp128 - 132
Masaaki Hayashi, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, Malcolm Wood, Colleen Fearns, Revati J Tatake
& Jiing-Dwan Lee
Published online: 04 December 2005 | doi:10.1038/nm1327
Abstract | Full text | PDF
(524K)
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Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice pp133 - 137
Kimiko Yamamoto, Takaaki Sokabe, Takahiro Matsumoto, Kimihiro Yoshimura, Masahiro Shibata, Norihiko Ohura, Toru Fukuda, Takashi Sato, Keisuke Sekine, Shigeaki Kato, Masashi Isshiki, Toshiro Fujita, Mikio Kobayashi, Koichi Kawamura, Hirotake Masuda, Akira Kamiya
& Joji Ando
Published online: 04 December 2005 | doi:10.1038/nm1338
Abstract | Full text | PDF
(480K)
| Supplementary Information
See also: News and Views by Burnstock |
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| Technical Reports | Top |
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Lipid microarrays identify key mediators of autoimmune brain inflammation pp138 - 143
Jennifer L Kanter, Sirisha Narayana, Peggy P Ho, Ingrid Catz, Kenneth G Warren, Raymond A Sobel, Lawrence Steinman
& William H Robinson
Published online: 11 December 2005 | doi:10.1038/nm1344
Abstract | Full text | PDF
(252K)
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In vivo imaging of islet transplantation pp144 - 148
Natalia V Evgenov, Zdravka Medarova, Guangping Dai, Susan Bonner-Weir
& Anna Moore
Published online: 25 December 2005 | doi:10.1038/nm1316
Abstract | Full text | PDF
(540K)
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