Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

MicroRNAs: 'ribo-regulators' of glucose homeostasis

Insulin secretion regulates glucose homeostasis and its dysregulation causes type 2 diabetes. Short noncoding microRNAs have now been shown to control exocytosis, the final event in insulin secretion. This discovery opens potential perspectives for diabetes therapy.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: MicroRNA-mediated regulation of insulin exocytosis in the pancreatic beta cell.

Simon Fenwick

References

  1. Du, T. & Zamore, P.D. Development 132, 4645–4652 (2005).

    Article  CAS  Google Scholar 

  2. He, L. & Hannon, G.J. Nat. Rev. Genet. 5, 522–531 (2004).

    Article  CAS  Google Scholar 

  3. O'Donnell, K.A., Wentzel, E.A., Zeller, K.I., Dang, C.V. & Mendell, J.T. Nature 435, 839–843 (2005).

    Article  CAS  Google Scholar 

  4. Lu, J. et al. Nature 435, 834–838 (2005).

    Article  CAS  Google Scholar 

  5. Jin, P., Alisch, R.S. & Warren, S.T. Nat. Cell Biol. 6, 1048–1053 (2004).

    Article  CAS  Google Scholar 

  6. Poy, M.N. et al. Nature 432, 226–230 (2004).

    Article  CAS  Google Scholar 

  7. Weir, G.C. & Bonner-Weir, S. Diabetes 53 Suppl 3, S16–S21 (2004).

    Article  CAS  Google Scholar 

  8. Burgoyne, R.D. & Morgan, A. Physiol. Rev. 83, 581–632 (2003).

    Article  CAS  Google Scholar 

  9. Rorsman, P. & Renstrom, E. Diabetologia 46, 1029–1045 (2003).

    Article  CAS  Google Scholar 

  10. Maechler, M. & C.B., W. Nature 414, 807–814 (2001).

    Article  CAS  Google Scholar 

  11. Lang, T. et al. Biophys. J. 78, 2863–2877 (2000).

    Article  CAS  Google Scholar 

  12. Tillmar, L., Carlsson, C. & Welsh, N. J. Biol. Chem. 277, 1099–1106 (2002).

    Article  CAS  Google Scholar 

  13. Knoch, K.P. et al. Nat. Cell Biol. 6, 207–214 (2004).

    Article  CAS  Google Scholar 

  14. Lagos-Quintana, M., Rauhut, R., Lendeckel, W. & Tuschl, T. Science 294, 853–858 (2001).

    Article  CAS  Google Scholar 

  15. Humphreys, D.T., Westman, B.J., Martin, D.I. & Preiss, T. Proc. Natl. Acad. Sci. USA 102, 16961–16966 (2005).

    Article  CAS  Google Scholar 

  16. Krek, A. et al. Nat. Genet. 37, 495–500 (2005).

    Article  CAS  Google Scholar 

  17. Griffiths-Jones, S. Nucleic Acids Res. 32, D109–D111 (2004).

    Article  CAS  Google Scholar 

  18. Xie, X. et al. Nature 434, 338–345 (2005).

    Article  CAS  Google Scholar 

  19. Yamakuni, T. et al. FEBS Lett. 530, 94−98 (2002).

    Article  CAS  Google Scholar 

  20. Taoka, M. et al. J. Biol. Chem. 278, 5864–5870 (2003).

    Article  CAS  Google Scholar 

  21. Neco, P. et al. J. Biol. Chem. 279, 27450–27457 (2004).

    Article  CAS  Google Scholar 

  22. Gupta, S., Purcell, N.H., Lin, A. & Sen, S. J. Cell. Biol. 159, 1019–1028 (2002).

    Article  CAS  Google Scholar 

  23. Hammar, E.B. et al. J. Biol. Chem. 280, 30630–30637 (2005).

    Article  CAS  Google Scholar 

  24. Norlin, S., Ahlgren, U. & Edlund, H. Diabetes 54, 125–132 (2005).

    Article  CAS  Google Scholar 

  25. Krutzfeldt, J. et al. Nature 438, 685–689 (2005).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gauthier, B., Wollheim, C. MicroRNAs: 'ribo-regulators' of glucose homeostasis. Nat Med 12, 36–38 (2006). https://doi.org/10.1038/nm0106-36

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0106-36

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing