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Decoy receptor springs to life and eases fibrosis

Nature Medicine volume 12, pages 13–14 (2006)Cite this article

Cytokines secreted during tissue damage and inflammation can trigger the formation of fibrous tissue. The cytokine IL-13 is now shown to induce TGF-β, the major fibrotic cytokine. IL-13 does so through a receptor previously thought to relay no signal (pages 99–106).

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Figure 1: IL-13 induces production of TGF-β in macrophages through a two-step mechanism.

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  1. Barts and the London School of Medicine and Dentistry, London, E1 2AT, UK

    Thomas T MacDonald

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MacDonald, T. Decoy receptor springs to life and eases fibrosis. Nat Med 12, 13–14 (2006). https://doi.org/10.1038/nm0106-13

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