Focus
Focus on Targeted cancer therapies
- Focus issue:
- November 2013 Volume 19, No 11
We thank Genentech for their generous support, which has enabled us to make this collection of recently published articles freely available to the community for a period of six months.
Editorial
Focus on Targeted cancer therapies
Keeping pace with cancer - p1380
doi:10.1038/nm.3395
Full Text - Keeping pace with cancer | PDF (98 KB) - Keeping pace with cancer
Perspective
Focus on Targeted cancer therapies
Mechanisms of resistance to therapies targeting BRCA-mutant cancers - pp1381 - 1388
Christopher J Lord & Alan Ashworth
doi:10.1038/nm.3369
Abstract - | Full Text - Mechanisms of resistance to therapies targeting BRCA-mutant cancers | PDF (1,241 KB) - Mechanisms of resistance to therapies targeting BRCA-mutant cancers
Reviews
Focus on Targeted cancer therapies
The quest to overcome resistance to EGFR-targeted therapies in cancer - pp1389 - 1400
Curtis R Chong & Pasi A Jänne
doi:10.1038/nm.3388
Abstract - | Full Text - The quest to overcome resistance to EGFR-targeted therapies in cancer | PDF (1,069 KB) - The quest to overcome resistance to EGFR-targeted therapies in cancer | Supplementary information
Focus on Targeted cancer therapies
Tumor adaptation and resistance to RAF inhibitors - pp1401 - 1409
Piro Lito, Neal Rosen & David B Solit
doi:10.1038/nm.3392
Abstract - | Full Text - Tumor adaptation and resistance to RAF inhibitors | PDF (3,661 KB) - Tumor adaptation and resistance to RAF inhibitors
Focus on Targeted cancer therapies
Unraveling the therapeutic potential of the Hedgehog pathway in cancer - pp1410 - 1422
Dereck Amakye, Zainab Jagani & Marion Dorsch
doi:10.1038/nm.3389
Abstract - | Full Text - Unraveling the therapeutic potential of the Hedgehog pathway in cancer | PDF (1,217 KB) - Unraveling the therapeutic potential of the Hedgehog pathway in cancer
Focus on Targeted cancer therapies
Microenvironmental regulation of tumor progression and metastasis - pp1423 - 1437
Daniela F Quail & Johanna A Joyce
doi:10.1038/nm.3394
Abstract - | Full Text - Microenvironmental regulation of tumor progression and metastasis | PDF (20,354 KB) - Microenvironmental regulation of tumor progression and metastasis
Focus on Targeted cancer therapies
The epigenetics of epithelial-mesenchymal plasticity in cancer - pp1438 - 1449
Wai Leong Tam & Robert A Weinberg
doi:10.1038/nm.3336
Abstract - | Full Text - The epigenetics of epithelial-mesenchymal plasticity in cancer | PDF (1,366 KB) - The epigenetics of epithelial-mesenchymal plasticity in cancer
Focus on Targeted cancer therapies
Tumor metastasis: moving new biological insights into the clinic - pp1450 - 1464
Liling Wan, Klaus Pantel & Yibin Kang
doi:10.1038/nm.3391
Abstract - | Full Text - Tumor metastasis: moving new biological insights into the clinic | PDF (18,835 KB) - Tumor metastasis: moving new biological insights into the clinic