Advance online publication
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publicationArticles
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells
Thomas Duhen, Rebekka Geiger, David Jarrossay, Antonio Lanzavecchia & Federica Sallusto
Published online: 05 July 2009 | doi:10.1038/ni.1767
Helper T cells become polarized to effect a 'division of labor'. Sallusto and Spits and colleagues identify a new subset of skin-homing helper T cells, TH-22 cells, that secrete interleukin 22.
Abstract - Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells | Full Text - Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells | PDF (515 KB) - Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells | Supplementary information
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells
Sara Trifari, Charles D Kaplan, Elise H Tran, Natasha K Crellin & Hergen Spits
Published online: 05 July 2009 | doi:10.1038/ni.1770
Helper T cells become polarized to effect a 'division of labor'. Sallusto and Spits and colleagues identify a new subset of skin-homing helper T cells, TH-22 cells, that secrete interleukin 22.
Abstract - Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T: H: -17, T: H: 1 and T: H: 2 cells | Full Text - Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells | PDF (808 KB) - Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells | Supplementary information
Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils
Kang Chen, Weifeng Xu, Melanie Wilson, Bing He, Norman W Miller, Eva Bengtén, Eva-Stina Edholm, Paul A Santini, Poonam Rath, April Chiu, Marco Cattalini, Jiri Litzman, James B Bussel, Bihui Huang, Antonella Meini, Kristian Riesbeck, Charlotte Cunningham-Rundles, Alessandro Plebani & Andrea Cerutti
Published online: 28 June 2009 | doi:10.1038/ni.1748
Mature B cells express immunoglobulin D, but its function is unknown. Cerutti and colleagues show that respiratory mucosal B cells secrete immunoglobulin D, which activates basophils and enhances antimicrobial function.
Abstract - Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils | Full Text - Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils | PDF (1,137 KB) - Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell–stimulating programs in basophils | Supplementary information
Essential function for the GTPase TC21 in homeostatic antigen receptor signaling
Pilar Delgado, Beatriz Cubelos, Enrique Calleja, Nuria Martínez-Martín, Angel Ciprés, Isabel Mérida, Carmen Bellas, Xosé R Bustelo & Balbino Alarcón
Published online: 28 June 2009 | doi:10.1038/ni.1749
Tonic antigen receptor signaling contributes to the homeostasis of naive lymphocytes. Alarcón and colleagues show that resting lymphocytes transmit tonic antigen receptor signals through the GTPase TC21 to trigger the PI(3)K pathway.
Abstract - Essential function for the GTPase TC21 in homeostatic antigen receptor signaling | Full Text - Essential function for the GTPase TC21 in homeostatic antigen receptor signaling | PDF (775 KB) - Essential function for the GTPase TC21 in homeostatic antigen receptor signaling | Supplementary information
Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair
Maziar Divangahi, Minjian Chen, Huixian Gan, Danielle Desjardins, Tyler T Hickman, David M Lee, Sarah Fortune, Samuel M Behar & Heinz G Remold
Published online: 28 June 2009 | doi:10.1038/ni.1758
Macrophages infected with virulent Mycobacterium tuberculosis die by necrosis. Remold and colleagues show that virulent M. tuberculosis promotes necrosis by damaging the plasma membrane and inhibiting its repair.
Abstract - Mycobacterium tuberculosis: evades macrophage defenses by inhibiting plasma membrane repair | Full Text - Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair | PDF (560 KB) - Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair | Supplementary information
Mina, an Il4 repressor, controls T helper type 2 bias
Mariko Okamoto, Melanie Van Stry, Linda Chung, Madoka Koyanagi, Xizhang Sun, Yoshie Suzuki, Osamu Ohara, Hiroshi Kitamura, Atsushi Hijikata, Masato Kubo & Mark Bix
Published online: 28 June 2009 | doi:10.1038/ni.1747
Mouse strains show varying inherent biases to T helper type 2 (TH2) responses. Bix and colleagues identify Mina, a jumonji C protein, as a negative regulator of the gene encoding interleukin 4 whose expression inversely correlates with TH2 bias.
Abstract - Mina, an : Il4: repressor, controls T helper type 2 bias | Full Text - Mina, an Il4 repressor, controls T helper type 2 bias | PDF (862 KB) - Mina, an Il4 repressor, controls T helper type 2 bias | Supplementary information
The impact of negative selection on thymocyte migration in the medulla
Marie Le Borgne, Ena Ladi, Ivan Dzhagalov, Paul Herzmark, Ying Fang Liao, Arup K Chakraborty & Ellen A Robey
Published online: 21 June 2009 | doi:10.1038/ni.1761
Self-reactive thymocytes are eliminated through negative selection in the thymic medulla. Robey and colleagues find that autoreactive thymocytes show slower and more confined migration than that of polyclonal thymocytes in the medulla.
Abstract - The impact of negative selection on thymocyte migration in the medulla | Full Text - The impact of negative selection on thymocyte migration in the medulla | PDF (721 KB) - The impact of negative selection on thymocyte migration in the medulla | Supplementary information
Until print versions of AOP papers are published, they should be cited in the style "Author(s) Nature Immunology advance online publication, day month year (doi:10.1038/niXXXXX)". Once the print version (identical to the AOP) is published, it should be cited as follows: "Author(s) Nature Immunology volume, page (year); advance online publication, (doi:10.1038/niXXXXX)".
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